教育背景： 1975 - 1978 年，湘雅医学院，理学学士 1984 - 1987 年，河南医科大学，医学硕士 2000 - 2003 年，澳大利亚昆士兰大学，哲学博士 工作经历： 任职于武汉大学基础医学院生理学系，担任教授、系主任

内分泌因子（如 GH/IGF - 1、E2 和 VEGF）与中枢神经系统发育、心血管疾病和癌症发展之间的关系

Publication list (* Corresponding author) 1. Wu Y , Shen Y, Kang K , Zhang YH , Ao F , Wan Y *, Song J*, Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34t stem/progenitor cells, Atherosclerosis, 240:453~ 461,2015 2. Tang JM*, Luo B, Xiao JH, Lv YX , Li XL, Zhao JH, Zheng F, Zhang L, Wan Y* , VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart. International Journal of Cardiology,183: 221–231, 2015. 3. Liu Y, Zhao Z, Gao YM, Yang F and Wan Y*, MiRNA-181a is involved in IGF-1 mediated regulation of CREB1 expression in Hippocampus, Journal of Neurochemistry, 126(6): 771 - 80, 2013. 4. Liu Y, Wu T, Song J, Chen XL, Zhang Y, and Wan Y*, A mutant screening method by critical annealing temperature-PCR for site-directed mutagenesis, BMC Biotechnology, 13:21, 1-8, 2013 5. Tang HQ; Yu XM; Song J; Xu CS; Wan Y*. Changes in Growth Hormone (GH), GH Receptor and GH Signal Transduction in Hippocampus of Congenital Hypothyroid Rats. J Neurosci Res, 89:248–255，2011. 6. Jiang j#, Wan Y#, Wang XD#, Xu J, Harris JM, Lobie PE, Zhang Y, Zinn KR, DVM, Waters MJ, Frank SJ. Inhibitory GH Receptor Extracellular Domain Monoclonal Antibodies: Three-dimensional Epitope Mapping. Endocrinology, 152: 3777-3788, 2011. 7. Wu ZS, Yang K, Wan Y, Qian PX, Perry JK, Chiesa J, Mertani HC, Zhu T and Lobie PE Expression of Human GH and Human Prolactin Predict a Worse Survival Outcome in Patients with Mammary or Endometrial Carcinoma, J Clin Endocrin Metab，17,1235-1245, 2011. 8. Sherer R*, Wan Y, Dong HM, Cooper B, Morgan I, Peng BW, Liu J, Wang L, and Xu D, Positive impact of integrating histology and physiology teaching at a medical school in China, Adv Physiol Educ 38: 330–338, 2014; 9. He L, Zheng Y, Wan Y, Song J*, A shorter telomere is the key factor in preventing cultured human mesenchymal stem cells from senescence escape, Histochem Cell Biol, DOI 10.1007/s00418-014-1210-5, 2014 10. Yu Y, Li JX, Wan Y , Lu JY, Gao JM, Huang CS*, GADD45a Induction by Nickel Negatively Regulates JNKs/p38 Activation via Promoting PP2Ca Expression, PLOS ONE, 8:3( e57185) 1-9, 2013 11. Zheng Y, He L, Wan Y, Song J*. H3K9me-Enhanced DNA Hypermethylation of the p16(INK4a) Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal, Stem Cells Dev. 15;22(2):256-67, 2013. 12. Tang J, Wang J, Kong X, Yang J, Guo L, Zheng F, Zhang L, Huang Y, Wan Y*. Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway. Exp Cell Res. 315:3521–3531, 2009. 13. Yu YH, Wan Y*, and Huang CS*, The Biological Functions of NF-κB1 (p50) and its Potential as an Anti-Cancer Target，Current Cancer Drug Targets, Curr Cancer Drug Targets. 9(4):566-71, 2009. 14. Brown RJ#, Adams JJ#, Pelekanos RA#, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Karin A. Eidne KA, Parker MW, Waters MJ. A Model for Growth Hormone receptor Activation Based on Subunit rotation within a Constitutive Dimer. Nature: Struct Mol Biol. 12 (9):814-21. 2005. 15. Wan Y, McDevitt A, Shen B, Smythe ML, Waters MJ. Increased Site 1 affinity improves biopotency of porcine growth hormone: Evidence against diffusion dependent receptor dimerization. J. Biol. Chem. 279 (43): 44775-44784. 2004. 16. Wan Y, Zheng YZ, Harris JM, Brown RJ, and Waters MJ. Epitope Map for A Growth Hormone Receptor Agonist Monoclonal Antibody, Mab 263. Molecular Endocrinology. 17 (11): 2240-2250，2003.