2017.08- 至今 武汉大学高等研究院，教授，博导 2015.06-2017.07 美国波士顿学院，博士后，合作导师：Prof. Amir H. Hoveyda 2014.02-2015.05 美国哈佛大学，博士后，合作导师：Prof. Tobias Ritter 2013.07-2014.02 中科院上海有机化学研究所，研究助理 2008.09-2013.07 中科院上海有机化学研究所，博士，导师：胡金波研究员

催化有机合成方法学:新型催化剂的设计合成和催化反应研究 元素有机化学：基于硅/氟元素的有机化学反应及其在重要生物活性分子和功能材料中的合成应用研究

X. He, Y. Zhang, S. Liu, W. Zhang, Z. Liu, Y. Zhao, X. Shen*. "Photocatalytic Site-Selective Radical C(Sp3)–H Aminoalkylation, Alkylation and Arylation of Silanes." Nat. Synth. 2024, DOI: https://doi.org/10.1038/s44160-024-00664-9. Z. Li#, Z. Zhang#, Z. Zhang#, Y. Zhang, S. Liu*, X. Shen*. "Visible-Light-Induced Organocatalyzed C(sp2)-H Bond Functionalization of 1,3-Azoles with Trifluoroacetylsilanes. '' Sci. China Chem. 2024, DOI: https://doi.org/10.1007/s11426-024-2203-5. Y. Liu, Z. Zhu, Y. Zhang, Y. Zhang, S. Liu*, X. Shen*. "Stereoselective Synthesis of Silyl Enol Ethers with Acylsilanes and α,β-Unsaturated Ketones." Org. Lett. 2024. DOI: https://doi.org/10.1021/acs.orglett.4c01782. Y. Zhang, X. Shen*. ''Photothermal cascade metathesis and cyclization.'' Trends Chem. 2024, 6, 5, 274-275. G. Zhou#, Z. Guo#, S. Liu, X. Shen*. ''Divergent Synthesis of Fluoroalkyl Ketones through Controlling the Reactivity of Organoboronate Complexes.'' J. Am. Chem. Soc. 2024, ASAP, https://doi.org/10.1021/jacs.3c12150. S. Deng, C. Peng, Y. Niu, Y. Xu, Y. Zhang, X. Chen, H. Wang, S. Liu, X. Shen*. ''Radical Brook Rearrangement Mediated Olefin Difunctionalization with α-Fluoroalkyl-α-silyl Methanols.'' Acta Chim. Sinica 2023, DOI: 10.6023/A23110487. Y. Zhang, J. Wang, Y. Guo, S. Liu, X. Shen*. "Carbonyl Olefin Metathesis and Dehydrogenative Cyclization of Aromatic Ketones and gem-Difluoroalkenes." Angew. Chem. Int. Ed. 2023, e202315269. Y. Guo, G. Zhou, X. Shen*. "Synthesis of organofluorine compounds with acylsilanes." Chin. J. Chem. 2023, DOI: 10.1002/cjoc.202300569. Z. Li#, X. Chen#, C. Peng, Y. Xu, H. Wang, S. Liu, X. Shen*. ''Merging Radical Brook Rearrangement and 1,5-Hydrogen Atom Transfer: Facile Synthesis of Ketone-Containing ɑ-Fluoroalkyl Alcohols.'' ChemCatChem 2023, e202301075. C. Jin#, X. He#, S. Chen, Z. Guo, Y. Lan*, X. Shen*. "Axial Chirality Reversal and Enantioselective Access to Si-stereogenic Silylallene" Chem 2023, 9, 2956-2970. S. Chen, Y. Zhang, S. Liu, X. Shen*. ''Photocatalyzed [2+1] Cyclization of Alkenes and Silylated Trifluorodiazoethanes: Facile Entry into (Difluoromethylene)cyclopropanes'' Sci. China Chem 2023, 66, 3141–3147. Z. Li, Y. Zhang, Y. Zhang, X. He, X. Shen*. "Diastereoselective Synthesis of Monofluorocyclohexenes through Photocatalyzed Cascade Cyclization of gem-Difluoroalkenes and α,β-Unsaturated Carbonyl Compounds" Angew. Chem. Int. Ed. DOI: https://doi.org/10.1002/anie.202303218. G. Zhou#, Z. Guo#, X. Shen*. "Electron-Rich Oxycarbenes: New Synthetic and Catalytic Applications beyond Group 6 Fischer Carbene Complexes" Angew. Chem. Int. Ed. 2023, 62, e202217189. Y. Zhang#, Y. Zhang#, C. Ye, X. Qi*, L.-Z. Wu*, X. Shen*. ''Cascade cyclization of alkene-tethered acylsilanes and allylic sulfones enabled by unproductive energy transfer photocatalysis'' Nat. Commun. 2022, 13, 6111. S. Chen, X. He, C. Jin, W. Zhang, Y. Yang, S. Liu, Y. Lan*, K. N. Houk*, X. Shen*. "Nickel-Catalyzed Cross-Redistribution between Hydrosilanes and Silacyclobutanes" Angew. Chem. Int. Ed. 2022, 61, e202213431. Y. Zhang#, Y. Niu#, Y. Guo, J. Wang, Y. Zhang, S. Liu, X. Shen*. "Photocatalyzed Cascade Reactions of Cyclopropanols and α-Trifluoromethyl-Substituted Olefins for the Synthesis of Fused gem-Difluorooxetanes" Angew. Chem. Int. Ed. DOI: 10.1002/anie.202212201. P. Jin, X. Shen*. "SulfoxFluor as a deoxyfluorination reagent, and beyond" J. Fluorine Chem. 2022, 261-262: 110029. Z. Zhu, W. Zhang, Y. Zhang, S. Liu, and X. Shen.*''Visible-Light-Induced [4+1] Cyclization-Aromatization of Acylsilanes and ɑ, β-Unsaturated Ketones'' CCS Chemistry. 2022, DOI: 10.31635/ccschem.022.202202199. S. Chen, X. He, Y. Jin, Y. Lan,* X. Shen.* ''Copper-Catalyzed Regio- and Stereo-Selective Hydrosilylation of Terminal Allenes to Access (E)-Allylsilanes'' Nat. Commun, 2022, 13 (1): 3691. G. Zhou, X. Shen.* '' Visible-Light-Induced Organocatalyzed [2+1] Cyclization of Alkynes and (Trifluoroacetyl)silanes'' Synlett 2022, DOI: 10.1055/a-1840-5199. (Invited Synpacts). Y. Zhang, # G. Zhou, # X. Gong, # Z. Guo, X. Qi, * X. Shen.* ''Diastereoselective Transfer of Tri(di)fluoroacetylsilanes-Derived Carbenes to Alkenes'' Angew. Chem. Int. Ed. 2022, 61, e202202175. Y. Zhang, Y. Zhang, Y. Guo, S. Liu, X. Shen.* ''Reductive Quenching-Initiated Catalyst-Controlled Divergent Alkylation of α-CF3-Olefin'' Chem Catal. 2022, accepted. X. He, Y. Zhao, Z. Zhang, X. Shen.* “Tuning the Reactivity of Alkoxyl Radicals from Cyclization to 1,2-Silyl Transfer: Stereoselective Synthesis of β-Substituted Cycloalcohols” Org. Lett. 2022, 24, 1991-1995. X. Fang, # W. Wen, # P. Jin, W. Bao, S. Liu, H. Cong, X. Shen.* '' Synthesis of Enantioenriched Fluorinated Enol Silanes Enabled by Asymmetric Reductive Coupling of Fluoroalkylacylsilanes and 1,3-Enynes and Brook Rearrangement'' Acs Catal. 2022, 12, 2150-2157. G. Zhou, X. Shen.* ''Synthesis of Cyclopropenols Enabled by Visible-Light-Induced Organocatalyzed [2+1] Cyclization'' Angew. Chem. Int. Ed. 2022, 61, e202115334. X. Chen, Z. Zhu, S. Liu, Y.-H. Chen, X. Shen.* '' MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction.'' Chin. Chem. Lett. 2021, accepted. https://doi.org/10.1016/j.cclet.2021.10.083. (Invited contribution to the special collection on “Fluorine Chemistry”.) Z. Zhu, X. Chen, S. Liu, J. Zhang, X. Shen.* '' Synthesis of 1-Tri(di)fluoromethyl 1,4-Diketones Enabled by Radical Brook Rearrangement.'' Eur. J. Org. Chem. 2021, 4927. Y. Zhang, Y. Zhang, X. Shen.* ''Alkoxyl Radical-Mediated Synthesis of Functionalized Allyl tert-(Hetero)cyclobutanols and Their Ring-opening and Ring-expansion Functionalizations.'' Chem Catal. 2021, 1(2), 423. Z. Yang#, Y. Niu# , X. He, S. Chen, S. Liu, Z. Li, X. Chen, Y. Zhang, Y. Lan*, X. Shen.* ''Tuning the Reactivity of Alkoxyl Radicals from 1,5-Hydrogen Atom Transfer to 1,2-Silyl Transfer'' Nat. Commun. 2021, 12, 2131. X. Chen#, X. Gong#, Z. Li, G. Zhou, Z. Zhu, W. Zhang, S. Liu, X. Shen.* "Direct transfer of tri- and di-fluoroethanol units enabled by radical activation of organosilicon reagents" Nat. Commun. 2020, 11, 2756. Y. Zhang#, Y. Chen#, Z. Zhang, S. Liu, X. Shen.* “Synthesis of Stereodefined Trisubstituted Alkenyl Silanes Enabled by Borane Catalysis and Nickel Catalysis” Org. Lett 2020, 3, 970-975.