学习经历 1997 年 09 月 - 2001 年 06 月，就读于武汉大学生命科学学院生物学基地班，获学士学位。 2002 年 09 月 - 2008 年 12 月，在武汉大学生命科学学院微生物系攻读，获博士学位。 主要工作经历与任职情况 2001 年 09 月 - 2002 年 07 月，参加共青团中央青年志愿者研究生支教团进行支教工作。 2009 年 07 月 - 2020 年 07 月，担任武汉大学生命科学学院讲师。 2011 年 11 月 - 2013 年 11 月，在美国中佛罗里达大学医学院从事博士后研究工作。 2020 年 07 月 - 至今，担任武汉大学生命科学学院副教授。

病毒感染细胞生物学

1. Yuan, Yuncong, Xingran Wang, Jiadai Li, Lingling Han, Hang Du, Yidan Sun, Pu Yang, Zhou Zhou, Meijia Gu, Yang Lu, Chao Shen*. Single-Cell Sequencing Yields Insights in the Evolution of Foot-and-Mouth Disease Virus Persistent Infection. Frontiers in Cellular and Infection Microbiology, 2022, 12:940906. 2. Meijia Gu*, Huaqin Pan, Yuncong Yuan, Xuemin Zhou, Luojia Chen, Fang Fang, Liu Hu, Yaxuan Xie, Chao Shen*. Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identify Critical Biomarkers of COVID-19. Frontiers in Cellular and Infection Microbiology, 2022, 12: 882661. 3. Luojia Chen#, Xingran Wang#, Yuncong Yuan, Rui Hu, Qingrong Chen, Lijun Zhu, Meijia Gu*, Chao Shen*. Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications, Engineered Regeneration. 2022, 3(1): 59-72. 4. Gu Meijia, He Ti, Yuan Yuncong, Duan Suling, Li Xin*, Shen Chao*. Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer. Frontiers in Oncology. 2021,11: 4784. 5. Lingling Han#, Yuncong Yuan#, Jianjun Hu, Jiadai Li, Shumin Zhu, Pu Yang, Andi Cheng, Xinmei Li, Chao Shen*. Next-generation sequencing sheds light on the interaction between virus and cell during foot-and-mouth disease virus persistent infection. Veterinary Microbiology. 2021, 263: 109247. 6. Meijia Gu, Meimei Yang, Jing He, Sixuan Xia, Zhe Zhang, Yudong Wang, Congyi Zheng, Chao Shen*. A silver lining in cell line authentication: Short tandem repeat analysis of 1373 cases in China from 2010 to 2019. International Journal of Cancer. 2021, 1-7. 7. Libei Huang, Meijia Gu, Zhaoyu Wang, Tsz Wing Tang, Zonglong Zhu, Yuncong Yuan, Dong Wang, Chao Shen*, Ben Zhong Tang*, Ruquan Ye*. Highly Efficient and Rapid Inactivation of Coronavirus on Non‐Metal Hydrophobic Laser‐Induced Graphene in Mild Conditions. Advanced Functional Materials. 2021, 31, 2101195. 8. Meijia Gu, Jingxuan Liu, Meimei Yang, Mingmin Zhang, Jian Yang, Suling Duan, Xuxu Ding, Jie Liu, Chuguang Chen, Yundian Zeng, Chao Shen*. Advantages of a 21-loci short tandem repeat method for detection of cross- contamination in human cell lines. Gene. 2020, 763: 145048. 9. Yao Hao, Yao Huang, Jingyi Chen, Li Jiadai, Yuan Yuncong, Mingzhen Wang, Lingling Han, Xiu Xin, Hailong Wang, Danqing Lin, Fang Peng, Fang Yu, Congyi Zheng, Chao Shen*. Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling. Cell Proliferation. 2020, 53(8), e12869. 10. Hailong Wang, Xiu Xin*, Congyi Zheng, Chao Shen*. Single-Cell Analysis of Foot-and-Mouth Disease Virus. Frontiers in Microbiology. 2020, 11:361. 11. Jiadai Li, Lingling Han, Yao Hao, Yuncong Yuan, Mingzhen Wang, Xiu Xin, Hailong Wang, Fang Yu, Congyi Zheng, Chao Shen*. Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection. Virologica Sinica. 2019, 35:52-63. 12. Mingzhen Wang, Yu Wang, Yuehong Liu, Hailong Wang, Xiu Xin, Jiadai Li, Yao Hao, Lingling Han, Fang Yu, Congyi Zheng, Chao Shen*. SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation. PLOS ONE, 2019, 14(7):e0219989. 13. Meijia Gu, Chao Shen*. Novel cancer cell lines derived from primary breast tumors in Chinese patients. American Journal of Translational Research. 2018, 10(12):3956-3968. 14. Xiu Xin, Hailong Wang, Lingling Han, Mingzhen Wang, Hui Fang, Yao Hao, Jiadai Li, Hu Zhang, Congyi Zheng, Chao Shen*. Single-cell analysis of the impact of host-cell heterogeneity on infection with foot and mouth disease virus. Journal of Virology. 2018, 92(9), e00179-18. 15. Hailong Wang, Xiu Xin, Mingzhen Wang, Lingling Han, Jiadai Li, Yao Hao, Congyi Zheng, Chao Shen*. Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation. Archives of Virology, 2018, 163:1429–1438. 16. Lingling Han, Xiu Xin, Hailong Wang, Jiadai Li, Yao Hao, Mingzhen Wang, Congyi Zheng, Chao Shen*. Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome. Scientific Reports, 2018, 8:5074. 17. Hu Zhang, Qingyi Wang, Lingling Han, Congyi Zheng, Chao Shen*. Cross-species hybridization of foot-and-mouth disease virus-infected BHK-21 cells using human and mouse oligonucleotide microarrays. Acta virologica, 2017, 61(3): 299-307. 18. Hui Fang, Bing Yuan, Lingling Han, Xiu Xin, Hailong Wang, Fangyan Yu, Congyi Zheng*, Chao Shen*. Single‑cell analysis reveals the relevance of foot‑and‑mouth disease virus persistence to emopamil‑binding protein gene expression in host cells. Archives of Virology, 2017, 162(12):3791-3802. 19. Yaqing Huang, Yuehong Liu, Congyi Zheng*, Chao Shen*. Investigation of Cross-Contamination and Misidentification of 278 Widely Used Tumor Cell Lines. PLOS ONE, 2017, 12(1): e0170384. 20. Wei Xiong, Jie Yang，Mingzhen Wang, Hailong Wang, Zhipeng Rao, Cheng Zhong, Xiu Xin，Lin Mo，Shujuan Yu, Chao Shen*, Congyi Zheng*. Vinexin β interacts with Hepatitis C Virus NS5A modulating its hyperphosphorylation to regulate viral propagation. Journal of Virology, 2015, 89(14):7385-7400. 21. Bing Yuan, Hui Fang, Chao Shen*, Zheng Congyi*. Expression of porcine Mx1 with FMDV IRES enhances the antiviral activity against foot-and-mouth disease virus in PK-15 cells. Archives of Virology. 2015, 160(8):1989-1999.