学习经历 1995 年 09 月 - 1999 年 07 月，就读于安徽大学，获学士学位。 2000 年 09 月 - 2005 年 07 月，在中国科学技术大学攻读，获博士学位。 主要工作经历与任职情况 2005 年 08 月 - 2010 年 12 月，在加州理工学院生物系，先后担任博士后、科研助理。 2010 年 12 月 - 至今，担任武汉大学生命科学学院教授。

线粒体动态调控与质量控制

1. Li Chen#, Jun Dong#, Siyang Liao, Siyou Wang, Zhida Wu, Meiling Zuo, Bing Liu, Chaojun Yan, Yong Chen, He He, Qingtao Meng*, Zhiyin Song*. (2022) Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury. Hepatology. 2022. doi: 10.1002/hep.32471. Online ahead of print. 2. Li Shu#, Chao Hu#, Meng Xu, Jianglong Yu, He He, Jie Lin, Hongying Sha, Bin Lu, Simone Engelender, Minxin Guan, Zhiyin Song*. (2021) ATAD3B is a Mitophagy Receptor Mediating Clearance of Oxidative Stress-induced Damaged mtDNA. The EMBO Journal. 40(8):e106283 3. Zhida Wu#, Meiling Zuo#, Ling Zeng, Kaisa Cui, Bing Liu, Chaojun Yan, Li Chen, Jun Dong, Fugen Shangguan, Wanglai Hu, He He, Bin Lu, Zhiyin Song*. (2021) OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development. EMBO Reports. 22(1):e50827 4. Junhui Tang#, Kuan Zhang#, Jun Dong, Chaojun Yan, Chao Hu, Hongchao Ji, Liangyi Chen, Shi Chen, Huabin Zhao, Zhiyin Song*. (2020) Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact. Cell Death and Differentiation. 27(1):146-160 5. Chaojun Yan#, Longlong Gong, Li Chen, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Désaubry, Zhiyin Song* (2020) PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy. 16(3):419-434 6. Chao Hu#, Li Shu#, Xiaoshuai Huang, Jianglong Yu, liuju Li, Longlong Gong, Meigui Yang, Zhida Wu, Zhi Gao, Yungang Zhao, Liangyi Chen*, and Zhiyin Song* (2020) OPA1 and MICOS Regulate Mitochondrial Crista Dynamics and Formation. Cell Death & Disease. 11(10):940 7. Chaojun Yan#, Xiaoying Duanmu, Ling Zeng, Bing Liu, Zhiyin Song*. (2019) Mitochondrial DNA: Distribution, Mutations, and Elimination. Cells. 8(4). pii: E379. doi: 10.3390/cells8040379. 8. Fenglei Jian#, Dan Chen, Li Chen, Chaojun Yan, Bin Lu, Yushan Zhu, Shi Chen, Anbing Shi, David C Chan, Zhiyin Song.* (2018) Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Cell Reports. 23(10), 2989-3005 9. Muhammad Riaz Khan#, Shaoxun Xiang#, Zhiyin Song*, Mian Wu* (2017) The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation. The EMBO Journal. 36(23):3483-3500 10. Li H#, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z.* (2016) Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death and Differentiation, 23(3):380-92. 11. Kuan Zhang#, Huihui Li, Zhiyin Song* (2014) Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage. EMBO Reports, 15(5):576-85 12. Y Ruan#, H Li#, K Zhang, F Jian, J Tang, Z Song* (2013) Loss of Yme1L perturbates mitochondrial dynamics. Cell Death & Disease, 4:e896. doi: 10.1038/cddis.2013.414 13. Miao L#, Song Z#, Jin L, Zhu YM, Wen LP, Wu M. (2010) ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene, 29(5):711-722 14. Song Z#, Ghochani M, McCaffery JM, Frey TG, Chan DC*. (2009) Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Molecular Biology of the Cell, (15):3525-3532 15. Song Z#, Chen H, Fiket M, Alexander C, Chan DC*. (2007) OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. Journal of Cell Biology. 178(5):749-755 16. Song Z#, Wu M*. (2005) dentification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation. Oncogene. 14; 24(16): 2723-2734 17. Song Z#, Liu S, He H, Hoti N, Wang Y, Feng S, Wu M*. (2004) A Single Amino Acid Change (Asp 53->Ala53) Converts Survivin from anti-apoptotic to pro-apoptotic. Molecular Biology of the Cell. 15(3):1287-1296 18. Song Z#, Yao X, Wu M*. (2003) Direct interaction between Survivin and Smac is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis. Journal of Biological Chemistry. 278(25): 23130-23140