学习经历 1993 年 - 1997 年，就读于南京大学生物科学与技术系，获学士学位。 1997 年 - 2002 年，于中科院上海生命科学研究院生物化学与细胞生物学研究所攻读，获博士学位。 主要工作经历与任职情况 2002 年 - 2005 年，在美国德克萨斯大学西南医学中心从事博士后研究工作。 2005 年 - 2014 年，任职于中科院上海生命科学研究院生物化学与细胞生物学研究所，担任研究组长、研究员，同时担任博士生导师。 2014 年 - 至今，在武汉大学担任教授。 2022 年 - 至今，担任武汉大学副校长。 2022 年 - 至今，担任泰康医学院（基础医学院）院长。 2022 年 - 至今，担任泰康生命医学中心主任。

胆固醇代谢与代谢疾病

1) Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J and Song BL*. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature, 608(7922):413-420, 2022 2) Lu XY#, Shi XJ#, Hu A#, Wang JQ#, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W and Song BL*. Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis. Nature, 588(7838):479-484, 2020 3) Zhang YY#, Fu ZY#, Wei J#, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT* and Song BL*. A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science, 360(6393):1087-1092, 2018 4) Chu BB#, Liao YC#, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL and Song BL*. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell, 161(2):291-306, 2015 5) Luo J, Yang H and Song BL*. Mechanisms and regulation of cholesterol homeostasis. Nature Reviews Molecular Cell Biology, 21(4):225-245, 2020 6) Gong XM#, Li YF#, Luo J#, Wang JQ#, Wei J#, Wang JQ, Xiao T, Xie C, Hong J, Ning G, Shi XJ, Li BL, Qi W* and Song BL*. Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance. Nature Metabolism, 1(5):570-583, 2019 7) Hu A#, Zhang JZ#, Wang J, Li CC, Yuan M, Deng G, Lin ZC, Qiu ZP, Liu HY, Wang XW, Wei PC, He X, Zhao X*, Qiu WW* and Song BL*. Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate. Cell Research, 32(3):288-301, 2022 8) Wang JK, Li Y, Zhao X, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL* and Luo J*. Ablation of plasma prekallikrein decreases LDL cholesterol by stabilizing LDL receptor and protects against atherosclerosis. Circulation, 145:675-687, 2022 9) Xiao J, Xiong YN, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao XL, Luo J* and Song BL*. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein Cell, 12(4):279-296, 2021 10) Xiao J#, Luo J#, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X and Song BL*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Science China Life Sciences, 62(9):1117-1135, 2019 11) Wang YJ, Bian Y, Luo J, Lu M, Xiong Y, Guo SY, Yin HY, Lin X, Li Q, Chang CCY, Chang TY, Li BL* and Song BL*. Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation. Nature Cell Biology, 19(7):808-819, 2017 12) Xiao X#, Tang JJ#, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL, Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW* and Song BL*. Cholesterol modification of Smoothened is required for hedgehog signaling. Molecular Cell, 66(1):154-162, 2017 13) Li PS, Fu ZY, Zhang YY, Xu CQ, Ma YT, Li BL and Song BL*. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nature Medicine, 20(1):80-86, 2014 14) Liu TF, Tang JJ, Li PS, Shen Y, Li JG, Miao HH, Li BL* and Song BL*. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metabolism, 16(2):213-225, 2012 15) Tang JJ#, Li JG#, Qi W, Qiu WW, Li PS, Li BL and Song BL*. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metabolism, 13(1):44-56, 2011 16) Ge L#, Wang J#, Qi W#, Miao HH, Cao J, Qu YX, Li BL and Song BL*. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism,7(6):508-519, 2008 17) Cao J, Wang J, Qi W, Miao HH, DeBose-Boyd RA, Wang J, Li BL* and Song BL*. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism. Cell Metabolism, 6(2):115-128, 2007