孙桂鸿
教授
个人简介
教育背景 1990.09 - 1994.06,武汉大学,学士学位 2001.09 - 2006.06,武汉大学,硕士、博士学位 工作经历 1994.07 - 2013.05,武汉大学基础医学院结构中心,讲师、副教授 2008.10 - 2010.10,美国国立卫生研究所(NIH),访问学者 2013.05 - 2016.10,武汉大学微生物教研室,副教授 2016.11 - 至今,武汉大学微生物教研室,教授 获奖荣誉 获武汉大学教学论文三等奖 2016 年,获武汉大学 “烛光导航工程” 优秀导航师
研究领域
病毒感染免疫及其致病机理:主要聚焦病毒感染、免疫逃逸和被免疫清除过程中,病毒与宿主之间的相互作用,以及相互作用后导致的不同肿瘤的分子机理。 利用小分子调控病毒复制和肿瘤的产生: 主要目标是尝试利用小分子RNA、小分子多肽等干扰病毒感染和复制,抑制肿瘤的产生。
近期论文
1. Wang J, Chen J, Liu Y, Zeng X, Wei M, Wu S, Xiong Q, Song F, Yuan X, Xiao Y, Cao Y, Li C, Chen L, Guo M, Shi YB, Sun G*, Guo D*. Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP via NF-κB Signaling. Hepatology. 2019; 69(3):974-992. 2. Song F, Wei M, Wang J, Liu Y, Guo M, Li X, Luo J, Zhou J, Wang M, Guo D, Chen L*, Sun G*. Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis. Cancer Sci. 2019; 110(5):1633-1643. 3. Wang J, Sun G*. The function of autophagy in diseases caused by hepatitis B virus. Chinese Science Bulletin, 2019; 64( 30): 3109-3122.(in Chinese) 4. Guo Y, Wang J, Yuan S, Guo S, Liu D, Sun G*. The regulation of HBx in hepatitis B virus replication. Chinese Science Bulletin, 2019; 64( 30): 3101-3108. (in Chinese) 5. Xiong Q, Wu S, Wang J, Zeng X, Chen J, Wei M, Guan H, Fan C, Chen L*, Guo D*, Sun G*. Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression. Cell Biosci. 2017; 7:16. 6. Liu Z, Song F, Ma ZL, Xiong Q, Wang J, Guo D, Sun G*. Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity. Sci Rep. 2016; 6:32658. 7. Sun G*, Roediger J, Shi YB. Thyroid hormone regulation of adult intestinal stem cells: Implications on intestinal development and homeostasis. Rev Endocr Metab Disord. 2016; 17(4):559-569. 8. He M, Lin Y, Tang Y, Liu Y, Zhou W, Li C, Sun G*, Guo M*. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging (Albany NY). 2016l; 8(7):1442-56. 9. Sun G, Fu L, Wen L, Shi YB. Activation of Sox3 gene by thyroid hormone in the developing adult intestinal stem cell during Xenopus metamorphosis. Endocrinology. 2014; 155(12):5024-32. 10. Luu N, Wen L, Fu L, Fujimoto K, Shi YB*, Sun G*. Differential regulation of two histidine ammonia-lyase genes during Xenopus development implicates distinct functions during thyroid hormone-induced formation of adult stem cells. Cell Biosci. 2013; 3(1):43. 11. Sun G, Fu L, Shi YB. Epigenetic regulation of thyroid hormone-induced adult intestinal stem cell development during anuran metamorphosis. Cell Biosci. 2014; 28; 4:73. 12. Liu Z, Xiang Y, Sun G*. The KCTD family of proteins: structure, function, disease relevance. Cell Biosci. 2013; 24; 3(1):45. 13. Sun G, Heimeier RA, Fu L, Hasebe T, Das B, Ishizuya-Oka A, Shi YB. Expression profiling of intestinal tissues implicates tissue-specific genes and pathways essential for thyroid hormone-induced adult stem cell development. Endocrinology. 2013; 154(11):4396-407.