学习经历 2004.09 - 2008.06 于武汉大学生命科学学院生物学专业学习，获理学学士学位。 于武汉大学经济管理学院攻读第二学位，获管理学学士学位。 2008.09 - 2013.06，在武汉大学生命科学学院细胞生物学专业深造，获理学博士学位。 主要工作经历与任职情况 2013.06 - 2015.05，担任武汉大学生命科学学院师资博士后。 2015.05 - 2017.11，任武汉大学生命科学学院讲师。 2016.02 - 2017.08，作为博士后在美国 MD Anderson Cancer Center 进行研究工作。 2017.11 - 2022.11，晋升为武汉大学生命科学学院副教授。 2022.11 - 至今，担任武汉大学生命科学学院教授。 2023.06 - 至今，兼任免疫与代谢前沿科学中心兼职研究员。

抗病毒天然免疫与病毒免疫逃逸

发表论文（#第一作者，*通讯作者）： 1. Xu Yanran#, Shi Mengling#, Zhang Yu#, Kong Na, Wang Cong, Xiao Yifeng, Du Shishen, Zhu Qiyun, Lei Caoqi*. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. PNAS, 2022, doi.org/10.1073/pnas.2122805119. 2. Zeng Yan, Xu Shuai, Wei Yanli, Zhang Xuefeng, Wang Qian, Jia Yane, Wang Wanbing, Han Lu, Chen Zhaoshan, Wang Zhengxiang, Zhang Bo, Chen Hualan, Lei Caoqi*, Zhu Qiyun*. The PB1 Protein of Influenza A Virus Inhibits the Innate Immune Response by Targeting MAVS for NBR1-Mediated Selective Autophagic Degradation. Plos Pathogens, 2021. doi.org/10.1371/journal.ppat.1009300 3. Xu Yanran#, Lei Caoqi*. TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses. Frontiers in Immunology, 2021. doi.org/10.3389/fimmu.2020.608976 4. Wei Yanli#, Zeng Yan#, Zhang Xuegang, Xu Shuai, Wang Zhengxiang, Du Yingying, Zhang Bo, Lei Caoqi*, Zhu Qiyun*. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. Journal of Virology, 2020, 23;94(24):e01640-20 5. Zhong Xuan#, Feng Lu, Xu Wenhua, Wuxin, Ding Yidi, Zhou Yan, Lei Caoqi*, Shu Hongbing*. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating its ligand binding. Cellular & Molecular Immunology, 2020, 17(7):741-752. 6. Lei Caoqi#*, Wu Xin#, Zhong Xuan, Jiang Lu, Zhong Bo, Shu Hongbing*. USP19 inhibits TNFa- and IL-1b-triggered NF-kB activation by deubiquitinating TAK1. Journal of Immunology, 2019, 203(1):259-268. 7. Chen Zhen#, Lei Caoqi#, Wang Chao, Li Nan, Mrinal Srivastava, Tang Mengfan, Zhang Huimin, Choi Jongmin, Jung Sungyun, Qin Jun, Chen Junjie*. Global Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics. Nature Communications, 2019, 10: 104 8. Wang Junyong#, Zeng Yan, Xu Shuai, Yang Jiayun, Wang Wanbing, Ge Jinying, Yin Lei, Wang Zhengxiang, Han Lu, Cui Xiaole, Zhong Bo, Shu Hongbing, Chen Hualan, Lei Caoqi*, Zhu Qiyun*, A naturally occurring deletion in the effector domain of H5N1 influenza virus nonstructural protein 1 regulates viral fitness and host innate immunity. Journal of Virology, 2018, 92(11): e00149-18 9. Wang Junyong#, Lei Caoqi*, Ji Yanhong, Zhou Hongbo, Ren Yujie, Peng Qianqian, Zeng Yan, Jia Yane, Ge Jinying, Zhong Bo, Li Yu, Wei Jianzhong, Shu Hongbing, Zhu Qiyun*, Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-beta Signaling Pathways by Targeting VISA. Journal of Immunology, 2016, 197(12):4704-4713. 10. Lei Caoqi#, Zhang Yu, Li Mi, Jiang Liqun, Zhong Bo, Kim Yonghao, Shu Hongbing*, ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses. Journal of Innate Immunity, 2015, 7(2):153-164. 11. Lei Caoqi#, Zhang Yu, Xia Tian, Jiang Liqun, Zhong Bo, Shu Hongbing*, FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. Journal of Biological Chemistry, 2013, 288(18):12596-12604. 12. Lei Caoqi#, Zhong Bo, Zhang Yu, Zhang Jing, Wang Shuai, Shu Hongbing*， Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity, 2010, 33(6):878-889.