教育背景 2001 - 2005 年，武汉大学生命科学学院，本科 2005 - 2010 年，武汉大学生命科学学院病毒学国家重点实验室，博士 2010 - 2016 年，美国费城宾夕法尼亚大学，生殖发育方向博士后 工作经历 2016 - 至今，武汉大学基础医学院，教授 2022 - 至今，泰康生命医学中心，PI 获奖荣誉 2017 年，湖北省科技进步二等奖（母 - 胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用，排位 4/15） 2017 年，全国妇幼健康科学技术二等奖（不明原因复发性流产规范化评估治疗体系的建立及其机制研究，排位 4/10） 2018 年，中华医学会科技二等奖（母 - 胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用，排位 4/15） 2018 年，华夏医学科技三等奖（母 - 胎免疫调节机制及免疫性复发性流产诊疗体系的创新及应用，排位 4/15）

精子发生 睾丸衰老 生育调控药物 辅助生殖检测技术

（1）Junfeng Zhan#, Peng Cui, Ziqi Yu, Wei Qu , Mengcheng Luo﹡, SDX on the X chromosome is required for male sex determination, Cell Research, 2022. （2）Jianbo Li#, Panfeng Wu#, Zhoutao Cao #, Guanlan Huang, Zhike Lu, Jianfeng Yan, Heng Zhang, Yangfan Zhou, Hui Chen, Lijia Ma* and Mengcheng Luo*, 'Establish machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing'，Cell Reports, 2024 （3）Huijuan Lin # , Keren Cheng # , Hiroshi Kubota , Yemin Lan , Simone S Riedel , Kazue Kakiuchi , Kotaro Sasaki , Kathrin M Bernt , Marisa S Bartolomei , Mengcheng Luo*, P Jeremy Wang*，Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells，Genes&Development, 2022. （4）Yongjuan Guan#, N. Adrian Leu, Jun Ma, Lukáš Chmátal, Gordon Ruthel, Jordana C. Bloom, Michael A. Lampson, John C. Schimenti, Mengcheng Luo* and P. Jeremy Wang*, 'Skp1 Drives the Prophase I to Metaphase I Transition During Male Meiosis', Science Advances, 2020. （5）Huijuan Lin#, Isabella G Cossu, N Adrian Leu, Aniruddha J Deshpande, Kathrin M Bernt, Mengcheng Luo*, P Jeremy Wang*, 'The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis'，Development, 2023. （6）Jiong Li#, Ke Chen#, Xin Dong#, Yating Xu, Qi Sun, Honghong Wang, Zhen Chen, Cong Liu, Rong Liu, Zhe Yang, Xiangfei Mei, Rongyu Zhang, Liuping Chang, Zongwen Tian, Jianjun Chen, Kaiwei Liang*, Chunjiang He*, Mengcheng Luo*，'YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation'，Cell Proliferation, 2022. （7） Mengcheng Luo#, Fang Yang, N Adrian Leu, Jessica Landaiche, Mary Ann Handel, Ricardo Benavente, Sophie La Salle, P Jeremy Wang*, 'Meiob Exhibits Single-Stranded DNA-Binding and Exonuclease Activities and Is Essential for Meiotic Recombination', Nature Communications, 2013. （8）Mengcheng Luo#, Jian Zhou, N Adrian Leu, Carla M Abreu, Jianle Wang, Montserrat C Anguera, Dirk G de Rooij, Maria Jasin, P Jeremy Wang*, 'Polycomb Protein Scml2 Associates with Usp7 and Counteracts Histone H2a Ubiquitination in the XY Chromatin During Male Meiosis', PLoS Genetics, 2015.