学习经历 1999 年 - 2003 年，就读于武汉大学，获学士学位。 2003 年 - 2010 年，在美国康涅狄格大学攻读，获博士学位。 主要工作经历与任职情况 2010 年 - 2014 年，在美国华盛顿大学药理学系从事博士后研究工作。 2014 年 - 2022 年 06 月，担任武汉大学生命科学学院副教授。 2022 年 06 月 - 至今，担任武汉大学生命科学学院教授。

低密度脂蛋白受体的稳定性调控与胆固醇代谢平衡和动脉粥样硬化的关系

代表性论文（#并列第一作者，*通讯作者） 1) Wang JK#, Li Y, Zhao X, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL*, Luo J*. Ablation of plasma prekallikrein decreases LDL cholesterol by stabilizing LDL receptor and protects against atherosclerosis. Circulation 145:675-687. (2022) 2) Adi D#, Lu XY#, Fu ZY#, Wei J, Baituola G, Meng YJ, Zhou YX, Hu A, Wang JK, LuXF, Wang Y, Song BL, Ma YT*, Luo J*. IDOL G51S variant is associated with high blood cholesterol and increases low-density lipoprotein receptor degradation. Arterioscler Thromb Vasc Biol. 39(12):2468-2479. (2019) 3) Li BT#, Sun M, Li YF, Wang JQ, Zhou ZM, Song BL, Luo J*. Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease. PLoS Genet. 16(8):e1008955. (2020) 4) Jiang SY#, Tang JJ#, Xiao X, Qi W, Wu S, Jiang C, Hong J, Xu J*, Song BL*, Luo J*. Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase. PLoS Genet. 15(7):e1008289. (2019) 5) Li, MX#, Yang Y#, Zhao, Q, Wu, Y, Song, L, Yang, H, He, M, Gao, H, Song, BL, Luo J*, Rao, Y*. Degradation versus inhibition: development of proteolysis-targeting chimeras for overcoming statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Med Chem. 63(9):4908-4928. (2020) 6) Luo J#, Yang H, Song BL*. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 21(4):225-245. (2020) 7) Xiao J#, Xiong YN, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao XL, Luo J*, Song BL*. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein Cell 12(4):279-296. (2021) 8) Wang JQ#, Lin ZC, Li LL, Zhang SF, Li WH, Liu W, Song BL, Luo J*. SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1. J Biol Chem. 296:100032. (2021) 9) Xiao J#, Luo J#, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 62(9):1117-1135. (2019) 10) Hu A#, Zhao XT, Tu H, Xiao T, Fu T, Wang Y, Liu Y, Shi XJ, Luo J*, Song BL*. PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis. J Lipid Res. 59(3): 507-514. (2018)