教育背景 2003 - 2007 年，武汉大学，生物学基地班，学士 2007 - 2009 年，武汉大学生命科学学院，生物化学与分子生物学，硕士 2012 - 2016 年，美国 Stowers 医学研究所，博士 工作经历 2011.06 - 2011.12，美国 Stowers 医学研究所，Predoctoral Researcher 2012.01 - 2016.05，美国 Stowers 医学研究所，博士研究生 2016.07 - 2018.03，美国西北大学 Feinberg 医学院，博士后 2018.03 - 至今，武汉大学基础医学院，教授（2018.05 - 2018.10，美国西北大学 Feinberg 医学院，访问学者） 获奖荣誉 入选国家级人才计划

遗传变异和表观遗传变异所导致的血液肿瘤的发病机制和靶向治疗 转录成瘾机制和新靶标鉴定 基于转录成瘾机制的小分子靶向药物开发

After 2019: 1. Qiu M., Yin Z., Wang H., Lei L., Li C., Cui Y., Dai R., Yang P., Xiang Y., Li Q., Lv J., Hu Z., Chen M., Zhou H., Fang, P.*, Xiao R.*, Liang K.* CDK12 and Integrator-PP2A Complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation. Science Advances 2023. 2. Wang D., Yin Z., Wang H., Wang L., Li T., Xiao R., Xie T., Han R., Dong R., Liu H.*, Liang K.*, Qing G.* The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma. Science Advances 2023, 9:eadf0005. 3. Li C., Yin Z., Xiao R., Huang B., Cui Y., Wang H., Xiang Y., Wang L., Lei L., Ye J., Li T., Zhong Y., Guo F., Xia Y., Fang P. *, Liang K.* G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes. Genome Biology, 2022, 23:259 4. H. Wang, C. Li, K. Liang*. Genome-Wide Native R-Loop Profiling by R-Loop Cleavage Under Targets and Tagmentation (R-Loop CUT&Tag). Methods Mol. Boil: R-Loops, 2022 (Bookchapter) 5. X. Lan, S. Ding, T. Zhang, Y. Yi, C. Li, W. Jin, J. Chen, K. Liang, H. Wang, W. Jiang. PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nature Communications, 2022. 4601 (13) 6. C. Li#, H. Wang#, Z. Yin#, P. Fang#, R. Xiao, Y. Xiang, W. Wang, Q. Li, B. Huang, J. Huang, K. Liang*. Ligand-induced Native G-quadruplexes Stabilization Impairs Transcription Initiation. Genome Research, 2021. 31: 1546-1560 (封面论文) 7. K. Wang, H. Wang, C. Li, Z. Yin, R. Xiao, Q. Li, Y. Xiang, W. Wang, J. Huang, L. Chen, P. Fang*, K. Liang*. Genomic Profiling of Native R-loops with a DNA-RNA Hybrid Recognition Sensor. Science Advances, 2021. 7: eabe3516 8. Zheng. H., Qi. Y., Hu. S., Cao. X., Xu. C., Yin. Z., Chen. X., Li. Y., Liu. W., Li. J., Wang. J., Wei, G., Liang, K., Chen. F., and Xu. Y. Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science, 2020. 370. 9. Cao, K., Ugarenko, M., Ozark, P.A., Wang, J., Marshall, S.A., Rendleman, E.J., Liang, K., Wang, L., Zou, L., Smith, E.R., et al. DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation. Proc Natl Acad Sci U S A, 2020. 117, 27365-27373.