学习经历 1992 年 - 1996 年，就读于中南民族大学，获学士学位。 1999 年 - 2004 年，在武汉大学生命科学学院攻读，获博士学位。 2004 年 - 2008 年，于哈佛大学医学院从事博士后研究工作。 主要工作经历及任职情况 1996 年 - 1999 年，在湖北省农业科学院担任实习研究员。 2008 年 - 2012 年，任武汉大学生命科学学院副教授。 2012 年 - 至今，担任武汉大学生命科学学院教授。

1.原癌基因和抑癌基因在肿瘤发生发展中的信号转导及调控关系； 2.针对特定靶位点的抗癌药物分子机理研究。

代表性论文：（*通讯作者） 1.Man Yu, Ting Liu, Yicheng Chen, Yafang Li,Wenhua Li*. Combination Therapy with Protein Kinase Inhibitor H89 and Tetrandrine Elicits Enhanced Synergistic Antitumor Efficacy.Journal of Experimental & Clinical Cancer Research. 2018, 37:114 2.Guixian Wu, Ting Liu, Han Li, Yafang Li, Dengju Li,Wenhua Li*. c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation.Cell Death Disease. 2018, 9:473 3.Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li,Wenhua Li*. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells.Journal of Experimental & Clinical Cancer Research. 2018, 37(1):7 4.Ting Liu, Zhenxing Zhang, Chunjie Yu, Chang Zeng, Xiaoqing Xu, Guixian Wu, Zan Huang,Wenhua Li*. Tetrandrine antagonizes acute megakaryoblastic leukemia growth by forcing autophagy-mediated differentiation.British Journal of Pharmacology. 2017, 174:4308-4328. 5.Yicheng Chen, Chang Zeng, Yao Zhan, Haiqing Wang, Xinnong Jiang,Wenhua Li*. P85α aberrantly low expression in stromal fibroblasts promotes breast cancer cell metastasis through exosomes mediated paracrine Wnt10b.Oncogene. 2017, 36:4692-4705. 6.Zhaohua Ping, Hui Xu, Ting Liu, Junchao Huang, Yan Meng, Xiaojuan Xu*,Wenhua Li* and Lina Zhang*. Anti-hepatoma activity of the stiff branched -D-glucan and effects of molecular weight.Journal of materials Chemistry B. 2016, 4:4565-4573 7.Jiali Wan, Jia-Hong Wang, Ting Liu, Zhixiong Xie, Xue-Feng Yu,Wenhua Li*. Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo.Scientific Reports. 2015, 5:11398; doi: 10.1038/srep11398. 8.Ting Liu, Qiuxu Men, Guixian Wu, Chunrong Yu, Zan Huang, Xin Liu*,Wenhua Li*. Tetrandrine inhibits proliferation and induces autophagy mediate differentiation by activating ROS and Notch1 signaling in NB4 leukemia cells.Oncotarget. 2015, 6:7992-8006. 9.Haiqing Wang, Ting Liu, Lu Li, Qin Wang, Chunrong Yu, Xin Liu*,Wenhua Li*. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species.Cell & Bioscience. 2015 5:4. 10.Liufeng Mei, Yicheng Chen, Zhimeng Wang, Jian Wang, Jiali Wan, Chunrong Yu, Xin Liu,Wenhua Li*. Synergistic antitumor effects of tetrandrine and chloroquine combination therapy in human cancer.British Journal of Pharmacology. 2015, 172:2232–45. 11.Ke Gong, Zhenxing Zhang, Yicheng Chen,Hong-Bing Shu,Wenhua Li*. Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma.European Journal of Pharmacology. 2014, 738:142-52. 12.Yu Song, Ke Gong, Hong Yan, Wei Hong, Le Wang, Yingliang Wu,Wenhua Li*, Wenxin Li*, Zhijian Cao*. Sj7170, a serine protease peptide inhibitor from the venom of the scorpion Scorpiops jendeki, promotes tumorigenesis and metastasis of human glioblastoma cells in vitro and in vivo.Journal of Biological Chemistry. 2014, 289:11667-80. 13.Jingru Li, Yicheng Chen, Jiali Wan, Xin Liu, Chunrong Yu,Wenhua Li*. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells.British Journal of Pharmacology. 2014, 171:3182-95. 14.Jiali Wan, Ting Liu, Liufeng Mei, Jingru Li, Ke Gong, Chunrong Yu,Wenhua Li*. Synergistic antitumor activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling. British Journal of Cancer. 2013,109:342-50. 15.Yan Zhang,Wenhua Li*, Liming Wang, Ping Shen, Zhixiong Xie. Adenosine monophosphate affects competence development and plasmid DNA transformation in Escherichia coli.Current Microbiology. 2013,67:550-6. 16.Hai-Ming Hu, Yicheng Chen, Lu Liu, Chuan-Geng Zhang, Wei Wang, Ke Gong, Zan Huang, Ming-Xiong Guo, Wen-Xin Li* andWenhua Li*. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.FASEB Journal. 2013, 27:163-73.