学习经历 1992 年 - 1997 年，就读于原湖北医科大学临床医疗专业，获学士学位。 1997 年 - 2000 年，在武汉大学医学院攻读组织胚胎学专业，获硕士学位。 2002 年 - 2006 年，于日本福岛医科大学学习免疫学专业，获博士学位。 主要工作经历与任职情况 1997 年 - 2002 年，在武汉大学医学院组织胚胎学教研室，先后担任助教、讲师。 2006 年 - 至今，在武汉大学生命科学学院，先后担任副教授、教授，并担任博士生导师。

1. 抗病毒天然免疫应答的信号转导调控 2. 炎症相关信号转导调控 主要研究抗感染天然免疫的干扰素效应及炎症反应的信号转导调控机制，在分子、细胞和动物水平，探索抗感染天然免疫信号通路的异常与炎症性疾病、自身免疫性疾病之间的关联，为病毒性传染病、炎症性疾病及自身免疫性疾病的防治提供分子靶标。

代表性论文： 1. Zhang, J., Zhou, E. C., He, Y., Chai, Z. L., Ji, B. Z., Tu, Y., Wang, H. L., Wu, W. Q., Liu, Y., Zhang, X. H., and Liu, Y*. (2023) ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation. Cell Rep 42, 112278 2. Tu, Y., Yin, X. J., Liu, Q., Zhang, S., Wang, J., Ji, B. Z., Zhang, J., Sun, M. S., Yang, Y., Wang, C. H., Yin, L., and Liu, Y*. (2022) MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST. PLoS Pathog 18, e1010989 3. Yang, Y., Hu, Y. H., and Liu, Y*. (2020) Wdfy1 deficiency impairs Tlr3-mediated immune responses in vivo. Cell Mol Immunol 17, 1014-1016 4. Ning, F., Li, X., Yu, L., Zhang, B., Zhao, Y., Liu, Y., Zhao, B., Shang, Y., and Hu, X. (2019) Hes1 attenuates type I IFN responses via VEGF-C and WDFY1. J Exp Med 216, 1396-1410 5. Sun, M. S., Zhang, J., Jiang, L. Q., Pan, Y. X., Tan, J. Y., Yu, F., Guo, L., Yin, L., Shen, C., Shu, H. B., and Liu, Y*. (2018) TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking. Cell Rep 25, 3086-3098 e3083 6. Jiang, L. Q., Xia, T., Hu, Y. H., Sun, M. S., Yan, S., Lei, C. Q., Shu, H. B., Guo, J. H., and Liu, Y*. (2018) IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cell Mol Immunol 15, 858-867 7. Jia, R., Zhang, S., Liu, M., Zhang, Y., Liu, Y., Fan, M., and Guo, J. (2016) HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells. Sci Rep 6, 35976 8. Chen, L. T., Hu, M. M., Xu, Z. S., Liu, Y., and Shu, H. B. (2016) MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes. J Immunol 197, 199-207 9. Hu, Y. H., Zhang, Y., Jiang, L. Q., Wang, S., Lei, C. Q., Sun, M. S., Shu, H. B., and Liu, Y*. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Rep 16, 447-455 10. Wang, S., Li, Y., Hu, Y. H., Song, R., Gao, Y., Liu, H. Y., Shu, H. B., and Liu, Y*. (2013) STUB1 is essential for T-cell activation by ubiquitinating CARMA1. Eur J Immunol 43, 1034-1041