刘勇 照片

刘勇

教授

所属大学: 武汉大学

所属学院: 高等研究院

邮箱:
liuy@sibs.ac.cn

个人主页:
https://gdyjy.whu.edu.cn/info/1017/1728.htm

个人简介

教育背景: 1982 - 1986 年,北京大学生物系生物化学专业,学士 1986 - 1989 年,北京大学生物系生物化学专业,硕士 1989 - 1995 年,美国 Rutgers 新泽西州立大学微生物学和分子遗传学系,博士 工作经历: 1995 - 2000 年,美国加州大学 Santa Barbara 分校分子、细胞与发育生物学系,博士后 2000 - 2003 年,美国加州 AlleCure/Mannkind 免疫生物技术公司研发部,Senior Scientist 2003 - 2015 年,中科院上海生命科学研究院营养科学研究所,研究组长、研究员、博士生导师 2008 - 2015 年,中科院营养与代谢重点实验室副主任 2008 - 2015 年,中科院上海生命科学研究院学术委员会委员 2011 - 2015 年,中科院上海营养科学研究所副所长 2015 年 - 至今,武汉大学生命科学学院教授 获奖荣誉: 2009 年明治乳业生命科学优秀奖 2011 年国务院政府特殊津贴 2011 年药明康德生命化学研究奖

研究领域

主要从事糖脂代谢调控的分子生理学机制研究,利用动物模型深入探索营养失衡、细胞应激与代谢紊乱的机制关联,力图深入了解肥胖、脂肪肝与 2 型糖尿病等衰老相关慢性疾病的分子基础,探寻新的药物干预靶标。

近期论文

1.Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L,Liu Y*.(2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses.J Hepatol.62:590-98. 2.Jiang S, Yan C, Fang QC, Shao ML, Zhang YL,Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z,Liu Y*, Jia WP*. (2014)Fibroblast Growth Factor 21Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis.J Biol Chem.289:29751-65.(Chosen asPaper of the Week) 3.Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X,LiuY*.(2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.Cell Res.24:1137-40. 4.Shao M, Shan B,Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L,LiuY*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Nat Commun.5:3528. 5.Zhang Q,Liu B,Cheng Y,Meng Q,Xia T,Jiang L,Chen S,Liu Y*,Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure.J Biol Chem.289:1779-87. 6.Zhang C, Li S, Yang L, Huang P, Li W, Wang S,ZhaoG, Zhang M, Pang X, Yan Z,LiuY*,ZhaoL*. (2013) Structural modulation of gut microbiota in life-longcalorie-restricted mice.Nat Commun.4:2163. 7.Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L,Liu Y*. (2012)A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.J Biol Chem.287(45):37973-85. 8.Yu Y,Sun Y,He S,Yan C,Rui L,Li W,Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Mol Cell Biol.32:3610-23. 9.Zhou B,Yang L,Li S,Huang J,Chen H,Hou L,Wang J,Green CD,Yan Z,Huang X,Kaeberlein M,Zhu L,Xiao H,Liu Y* andHan JD*. (2012)Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions.Proc. Natl. Acad.Sci. U.S.A. Plus109:E1201-9. 10. Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W andLiu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1ato Glucagon Signaling in Glucose Metabolism.Proc. Natl. Acad.Sci. U.S.A.108:15852-7. 11.Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*,Liu Y*. (2010)Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.FASEB J.24:3720-32. 12. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W,Liu Y*. (2010)Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice.J. Lipid Res.51:2516-26. 13. You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* andLiu Y*. (2010) Tyr985signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance.Mol. Cell. Biol.30:1650-9.(Highlighted byEditor’s Choice,Science139, 141, 2010 andScience Signaling3, ec95, 2010) 14. Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y,Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.Cell Metab.11:427-37. 15. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*,Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells.Sci. Signal.3, ra7.(Highlighted inPerspective,Science Signaling3, pe7, 2010) 16. Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W andLiu Y*.(2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.Hepatology49:1166-75. 17. Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,Liu Y*.(2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.Proc. Natl. Acad.Sci. U.S.A.105: 18619-24.(Highlighted byNature China, 2008) 18. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W,Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells.J. Biol. Chem.281:33386-94.