教育经历 于武汉大学获得学士学位。 于武汉大学获得硕士学位。 于芝加哥洛约拉大学（Loyola University Chicago）获得博士学位。 在美国芝加哥大学肿瘤研究所（University of Chicago Ben May Institute for Cancer Research）担任博士后研究员。 在美国西北大学医学院（Northwestern University Feinberg School of Medicine）担任博士后研究员。 工作经历 曾在上海市儿童医院担任研究助理。 曾在 Loyola University Chicago 担任研究助理。 现任武汉大学生命科学学院教授。

细胞分化与肿瘤发生

发表论文（#并列第一作者*通讯作者）/Selected Publications 1. Sun, J.; Ding, J.; Shen, Q.; Wang, X.; Wang, M.; Huang, Y.; Zhang, X.; Zhu, H.; Zhang, F.; Wu, D.; Peng, M.; Zhang, Z.; Yuan, Y.; Li, W.; She, Z. G.; Zhang, X. J.; Li, H.; Zhang, P.*; Huang, Z*. Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma. J Hepatol. 2023, 78(3):627-642. 2. Sun, Jiaqi; Wang, Xiyang; Shen, Qingsong; Wang, Min; Chen, Shuxian; Zhang, Xuechun; Huang, Yongping; Zhang, Zhonglin; Li, Wenhua; Yuan, Yufeng; Huang, Zan. DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2. Cell Oncol (Dordr). 2022, 45(6):1187-1202. 3. Hu, Yufeng; He, Wenzhi; Huang, Yongping; Xiang, Hui; Guo, Juan; Che, Yan; Cheng, Xu; Hu, Fengjiao; Hu, Manli; Ma, Tengfei; Yu, Jie; Tian, Han; Tian, Song; Ji, Yan-Xiao; Zhang, Peng; She, Zhi-Gang; Zhang, Xiao-Jing; Huang, Zan*; Yang, Juan*; Li, Hongliang*. Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. Hepatology. 2021, 74(5):2508-2525. 4. Yan, Zhen-Zhen; Huang, Yong-Ping; Wang, Xin; Wang, Hai-Ping; Ren, Fei; Tian, Rui-Feng; Cheng, Xu; Cai, Jie; Zhang, Yan; Zhu, Xue-Yong; She, Zhi-Gang; Zhang, Xiao-Jing*; Huang, Zan*; Li, Hongliang*. Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice. Hepatology. 2019, 70(5):1750-1769. 5. Yang, Xuejing; Lu, Bin; Sun, Xueqin; Han, Cuijuan; Fu, Chunling; Xu, Kailin; Wang, Min; Li, Dengju; Chen, Zhichao; Opal, Puneet; Wen, Qiang; Crispino, John D; Wang, Qian-Fei*; Huang, Zan*. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. 2018, 32(7):1587-1597. 6. Wang, Xiaozhan; Mao, Wenzhe; Fang, Chun; Tian, Song; Zhu, Xueyong; Yang, Ling; Huang, Zan*; Li, Hongliang*. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression. J Hepatol. 2018, 68(1):118-129. 7. Qin, Juan-Juan; Mao, Wenzhe; Wang, Xiaozhan; Sun, Peng; Cheng, Daqing; Tian, Song; Zhu, Xue-Yong; Yang, Ling; Huang, Zan*; Li, Hongliang*. Caspase recruitment domain 6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1. J Hepatol. 2018, 69(5):1110-1122. 8. Yan, Feng-Juan; Zhang, Xiao-Jing; Wang, Wen-Xin; Ji, Yan-Xiao; Wang, Pi-Xiao; Yang, Yang; Gong, Jun; Shen, Li-Jun; Zhu, Xue-Yong; Huang, Zan*; Li, Hongliang*. The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis. Hepatology. 2017, 65(5):1492-1511. 9. Sun, Xueqin; Lu, Bin; Han, Cuijuan; Qiu, Wanlin; Jin, Qi; Li, Dengju; Li, Qiubai; Yang, Qiong; Wen, Qiang; Opal, Puneet; Kini, Ameet R; Crispino, John D; Huang, Zan. ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia. Blood Cancer J. 2017, 7(12):661-665. 10. Lu, Bin; Ren, Yujie; Sun, Xueqin; Han, Cuijuan; Wang, Hongyan; Chen, Yuxuan; Peng, Qianqian; Cheng, Yongbo; Cheng, Xiaoliang; Zhu, Qiyun; Li, Wenxin; Li, Hong-Liang; Du, Hai-Ning; Zhong, Bo*; Huang, Zan*. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3. Cell Host Microbe. 2017, 22(1):86-98 e84.