学习经历 1986 年 - 1990 年，就读于武汉大学生命科学学院生物化学专业，获学士学位。 1993 年 - 1996 年，在武汉大学生命科学学院生物化学专业深造，获硕士学位。 1996 年 - 1999 年，于武汉大学生命科学学院微生物学专业攻读，获博士学位。 主要工作经历与任职情况 1999 年 - 2001 年，任武汉大学生命科学学院讲师。 1999 年 - 2000 年，在香港理工大学应用生物及化学学系担任助理研究员。 2001 年 - 2003 年，作为博士后在美国肯塔基大学生物化学学系开展研究工作。 2001 年 - 2009 年，担任武汉大学生命科学学院副教授。 2009 年 - 至今，任武汉大学生命科学学院教授。

肿瘤生物学、神经生物学

代表性论文（*通讯作者） 1.Jun Wu, Jing Yan, Pingping Fang, Hai-bing Zhou, Kaiwei Liang∗, Jian Huang∗. Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor α antagonism. Cancer Letters. 469: 78–88. (2020). 2.Chen Cheng, Nan Zheng, Deyang Sun, Weishuo Fang, Lingling Zheng, Weihong Song,Jian Huang*. A Novel Compound YS‑5‑23 Exhibits Neuroprotective Effect by Reducing β‑Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2‑Induced Cytotoxicity in SH‑SY5Y Cells. Neurochemical Research. 45:2113–2127. (2020). 3.Pan Huang, Nan Zheng, Hai-bing Zhou,Jian Huang*. Curcumin inhibits BACE1 expression through the interaction between ERβ and NFκB signaling pathway in SH-SY5Y cells. Molecular and Cellular Biochemistry. 463:161–173. (2020). 4.Ming He, Wentao Ning, Zhiye Hu,Jian Huang, Chune Dong, Hai-Bing Zhou. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor a (ERa) and lysine specific demethylase 1 (LSD1) for treatment of breast cancer. European Journal of Medicinal Chemistry. 195,112281. (2020). 5.Qiuyu Meng, Xiaoyu Ma, Baohua Xie, Xiaofei Deng,Jian Huang,Hai-Bing Zhou and Chune Dong. Establishment of evaluation criteria for the development of high quality ERα-targeted fluorescent probes. Analyst. 145, 5989. (2020). 6.De-Yang Sun, Chen Cheng, Katrin Moschke,Jian Huangand Wei-Shuo Fang*. Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties. Molecules. 25, 102. (2020). 7.Yue Zhao, Chenxi Zhao, Jin Lua, Jun Wu, Changhao Li, Zhiye Hu, Wei Tian, Liang Yang, Jin Xiang, Haibin Zhou, Zixin Deng,Jian Huang∗, Kui Hong∗. Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader, Pharmacological Research. 146: 104294. (2019). 8.Wei-Shuo Fang, De-yang Sun, Shuang Yang, Chen Cheng, Katrin Moschkec, Tianqi Li, Shanshan Sun, Stefan F. Lichtenthalerc,Jian Huang, YinghongWang*. Discovery ofa series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR. Bioorg Chem. 92:103253. (2019). 9.Zhiye Hu, Yuanyuan Li, Baohua Xie, Wentao Ning, Yuan Xiao, Yuan Huang, Chenxi Zhao,Jian Huang*, Chune Dong*, Hai-Bing Zhou*. Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displayingimproved estrogen receptor α degradation activity. Eur J Med Chem. 8;182:111605. (2019). 10.Yong Wei, Jiawei Zhou, Jun Wu,Jian Huang*. ERβ promotes Aβ degradation via the modulation of autophagy. Cell Death Dis. 10(8):565. (2019).