教育背景： 1988.09 - 1991.07，原湖北医科大学，口腔专业 1997.09 - 2000.07，原湖北医科大学病毒研究所，医学硕士 2003.09 - 2006.07，武汉大学病原生物学系，医学博士 2000.11 - 2001.02，台湾中山医学院病毒研究中心，访问学者 2004.09 - 2004.12，日本福岛医科大学微生物系，访问学者 2005.09 - 2006.01，上海外国语大学英语高级班培训 2007.11 - 2008.11，美国宾夕法尼亚大学医学院 / 费城儿童医院过敏免疫系，访问学者 工作经历： 1991.11 - 1997.07，原湖北医科大学病毒研究所，研究实习员 2000.07 - 2003.09，武汉大学基础医学院医学病毒学研究所，讲师 2003.10 - 2010.10，武汉大学基础医学院医学病毒学研究所，副教授 2010.11 - 至今，武汉大学基础医学院医学病毒学研究所，教授，博导 2011.02 - 2011.10，国家自然科学基金委医学科学部，借调 2012.03 - 2012.05，国家自然科学基金委医学科学部，借调 2012.12 - 2020.12，武汉大学基础医学院，副院长 获奖荣誉： 2004 年，武汉大学医学院优秀教师称号 2005 年，国际抗病毒协会 “Travel Award” 奖 2005 年，湖北省科技进步二等奖 2009 年，湖北省自然科学二等奖 2009 年，湖北省大学生优秀成果奖叁等奖（指导教师） 2011 年，向近敏教育基金获得者 2012 年，武汉大学医学部医学突出贡献奖 2014 年，湖北省第十五届自然科学优秀学术论文二等奖 2014 年，朱裕璧医学奖 2015 年，湖北省卫生计生系统科技教育工作先进个人 2015 年，湖北省大学生优秀成果奖二等奖（指导教师） 2016 年，科技部创新人才推进计划重点领域创新团队 “病毒感染与防治创新团队”（核心成员） 2017 年，首届武汉大学本科优秀教学业绩奖（2015 - 2016 学年） 2016 - 2017 年度，武汉大学 “师德标兵” 称号 2017 - 2018 年度，武汉大学自然科学研究优秀科技管理工作者荣誉称号 2020 年，“珞珈抗疫・十大科研攻关人物” 2021 年，武汉大学基础医学院优秀共产党员称号

病毒分子流行病学；病毒感染免疫；抗病毒研究

研究方向为病毒性疾病的致病机理和抗病毒研究。目前主要研究领域和兴趣包括：以人类免疫缺陷病毒（HIV）和汉坦病毒（HV）为研究对象，从分子、病毒、宿主细胞和机体等不同层面上，研究病毒感染致病的分子机理；围绕病毒与宿主间的生态进化关系开展病毒遗传与进化的机制研究；利用从整体动物水平到细胞水平、基因水平等较为系统的抗病毒药效学评价筛选技术平台，从病毒感染的各个环节深入探讨药物的抗病毒机制，开发抗病毒的新技术和新药物。

Zhong CJ, Liu FL, Hajnik RJ, Yao L, Chen KJ, Wang MR, Liang YJ, Sun JR, Soong L, Hou W*, Hu HT*. Type-I IFN promotes humoral immunity in viral vector vaccination. J Virol, 2021, 95(22): e0092521. Meng FZ, Liu JB, Wang X, Wang P, Hu WH, Hou W*, Ho WZ*. TLR7 activation of macrophages by Imiquimod inhibits HIV infection through modulation of viral entry cellular factors. Biology-Basel, 2021, 10(7): 661. Zhang ZP, Yuan S, Xu ST, Guo DY, Chen L, Hou W*, Wang M*. Suppression of HIV-1 integration by targeting HIV-1 integrase for degradation with a chimeric ubiquitin ligase. Virol Sin, 2021, 36(3): 424-437. Shao DD#, Meng FZ#, Liu Y, Xu XQ, Wang X, Hu WH, Hou W*, Ho WZ*. Poly(dA:dT) suppresses HSV-2 infection of human cervical epithelial cells through RIG-I activation. Front Immunol, 2021, 11: 598884. Wang QW#, Yue M#, Yao PP, Zhu CQ, Ai LL, Hu D, Zhang B, Yang ZN, Yang XH, Luo F, Wang CH, Hou W*, Tan WL*. Epidemic trend and molecular evolution of HV family in the main hantavirus epidemic areas from 2004 to 2016, in P.R. China. Front Cell Infect Microbiol, 2021, 10: 584814. Xie LL, Ju Z, Zhong CJ, Wu YJ, Zan YX, Hou W*, Feng Y*. GTPase activity of MxB contributes to its nuclear location, interaction with nucleoporins and anti-HIV-1 activity. Virol Sin, 2021, 36(1): 85-94. Wang X#, Chen QZ#, Zan YX, Wang MR, Yan J, Guo WW, Li KJ, Liu YY, Luo F, Feng Y, Hou W*, Xiong HR*. Exosomal miR-145-5p derived from orthohantavirus-infected endothelial cells inhibits HTNV infection. FASEB J, 2020, 34: 13809-25. Guo JJ#, Lin XD#, Chen YM, Hao ZY, Wang ZX, Yu ZM, Lu M, Li K, Qin XC, Wang W, Holmes EC, Hou W*, Zhang YZ*. Diversity and circulation of Jingmen tick virus in ticks and mammals. Virus Evol, 2020, 6(2): veaa051. Xie LL#, Chen L#, Zhong CJ, Yu T, Ju Z, Wang MR, Xiong HR, Zeng Y, Wang JH, Hu HT, Hou W*, Feng Y*. MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6. Retrovirology, 2020, 17: 16. Wang MR#, Wu DD#, Luo F#, Zhong CJ, Wang X, Zhu N, Wu YJ, Hu HT, Feng Y, Wang X, Xiong HR*, Hou W*. Methadone inhibits viral restriction factors and facilitates HIV infection in macrophages. Front Immunol, 2020, 11: 1253. Chen QZ#, Wang X#, Luo F#, Li N, Zhu N, Lu S, Zan YX, Zhong CJ, Wang MR, Hu HT, Zhang YZ, Xiong HR*, Hou W*. HTNV sensitizes host toward TRAIL-mediated apoptosis - a pivotal anti-hantaviral role of TRAIL. Front Immunol, 2020, 11: 1072. Chen LJ#, Guo JJ#, Guo WW, Shen EX, Wang X, Li KJ, Yan J, Shi M, Li YR*, Hou W*. Molecular epidemiology and vaccine compatibility analysis of seasonal influenza viruses in Wuhan, 2016-2019. Virol Sin, 2020, 35(5): 556-565. Lu S#, Zhu N#, Guo WW, Wang X, Li KJ, Yan J, Jiang CP, Han SY, Xiang HM, Wu XH, Liu YY, Xiong HR, Chen LJ, Gong ZJ, Luo F*, Hou W*. RNA-Seq revealed a circular RNA-microRNA-mRNA regulatory network in hantaan virus infection. Front Cell Infect Microbiol, 2020, 10: 97. Chen HJ#, Guo JJ#, Luo F, Yu XC, Zhang W, Li JF, Zhao DC, Xu D, Gong Q, Liao J, Yang HX*, Hou W*, Zhang YZ*. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 2020, 395(10226): 809-15. Chen JT, Qin J, Li K, Xu QY, Wang XP, Plyusnin A, Hou W*, Zhang YZ*. Identification and characterization of a novel subtype of Tula virus in Microtus arvalis obscurus voles sampled from Xinjiang, China. Infect Genet Evol, 2019, 75: 104012. Qu D#, Sun WW#, Li L, Ma L, Sun L, Jin X, Li TS*, Hou W*, Wang JH*. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. Nucleic Acids Res, 2019, 47(6): 3013-3027. Li N#, Luo F#, Chen QZ, Zhu N, Wang H, Xie LL, Xiong HR, Yue M, Zhang Y, Feng Y*, Hou W*. IFN-λs inhibit hantaan virus infection through the JAK-STAT pathway and expression of Mx2 protein. Genes Immun, 2019, 20(3): 234-244. Huang QL#, Chen L#, Luo MQ, Lv H, Luo D, Li T, Huang SL, Xie LL, Teng Y, Liu ZY, Luo F, Xiong HR, Zeng Y, Hou W*, Feng Y*. HIV-1 induced miR-146a attenuates monocytes migration by targeting CCL5 in human primary macrophages. AIDS Res Hum Retroviruses, 2018, 34(7): 580-589. Luo F#, Liao FL#, Wang H, Tang HB, Yang ZQ, Hou W*. Evaluation of antibody-dependent enhancement of SARS-CoV infection in rhesus macaques immunized with an inactivated SARS-CoV vaccine. Virol Sin, 2018, 33(2): 201-204. Chen QZ#, Luo F#, Lu MX#, Li N, Teng Y, Huang QL, Zhu N, Wang GY, Yue M, Zhang Y, Feng Y, Xiong HR*, Hou W*. HTNV-induced upregulation of miR-146a in HUVECs promotes viral infection by modulating pro-inflammatory cytokine release. Biochem Biophys Res Commun, 2017, 493(1): 807-813. Chen XP#, Xiong HR#, Zhu N, Chen QZ, Wang H, Zhong CJ, Wang MR, Lu S, Luo F, Hou W*. Lack of association between integrin αvβ3gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. Virol Sin, 2017, 32(1): 73-79. Yang MR, Feng F, Liu YF, Wang H, Yang ZQ, Hou W*, Liang HH*. pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating. J Gen Virol, 2016, 97(9): 2149-2156. Li L, Feng HM, Da Q, Jiang HL, Chen L, Xie LL, Huang QL, Xiong HR, Luo F, Kang L, Zeng Y, Hu HT, Hou W*, Feng Y*. Expression of HIV-encoded microRNA-TAR and its inhibitory effect on viral replication in human primary macrophages. Arch Virol, 2016, 161(5): 1115-1123.