学习经历： 1985.09~1990.07 湖北医科大学，攻读学士学位 1994.09~1997.07 湖北医科大学，攻读硕士学位 1997.09~2000.06 华中科技大学，攻读博士学位 主要工作经历与任职： 1990.07~1994.09 广州军区武汉总医院，住院医师 2000.07~2002.07 武汉大学生命科学学院，博士后研究 2002.07~2005.09 广州军区武汉总医院，副主任医师，副教授，硕导 2005.09~2006.11 澳大利亚悉尼大学，访问学者 2006.11~2007.11 武汉大学病理生理学教研室，副教授，硕导 2007.11~至今 武汉大学病理生理学教研室，教授，博导

主要从事神经系统离子通道病的发病机制和防治研究，利用生物信息学、分子生物学、神经电生理等技术平台，揭示KCNQ、Kv1.3等离子通道与癫痫、多发性硬化症等神经系统疾病发生、发展的关系，并结合分子流行病学及临床研究，发现针对癫痫、多发性硬化症等神经系统离子通道病的新机制、新靶标。同时，针对新发现的离子通道药物靶标开展药物研发，基于我国特有动物多肽毒素资源，筛选、鉴定特异性作用于疾病相关膜通道及受体的多肽毒素，进一步开发新的具有自主知识产权及重要药用前景的多肽毒素。

1. Zhao YP, Huang J, Yuan XL, Peng BW, Liu WH, Han S*, He XH*. Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases.Toxins. 2015, 7(5), 1749-1764 2. Huang WX, Yu F, Sanchez RM, Liu YQ, Min JW, Hu JJ, Bsoul N, Han S, Yin J, Liu WH, He XH*, Peng BW*. TRPV1 promotes the occurrence of repetitive febrile seizures by increasing the secretion of pro-inflammatory cytokines in the immature brain. Brain Behav Immun. 2015, pii: S0889-1591(15)00030-6. doi: 10.1016. [Epub ahead of print] 3. Qiu YY, He XH*, Zhang YN and Li JX*. Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats. Sci Rep. 2014; 4:6605 4. Wang ZC, Fan YT, Xu J, Li L, Heng DH, Han S, Yin J, Peng BW, Liu WH*, He XH*. Transcriptome Analysis of the Hippocampus in Novel Rat Model of Febrile Seizures. PLoS One. 2014, 9(4):e95237. doi: 10.1371 5. Qiu YY, Li JX*, He XH*. Behavioral effect of the imidazoline I2 receptor ligand BU99006. Behav Pharmacol. 2014; 25(2): 130-136 6. Zhang YY, Chen X, Lian HW, Liu JM, Zhou BY, Han S, Peng BW, Yin J, Liu WH*, He XH*. MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. Oncol Rep. 2014, 31(3):1445-1452. 7. Xu J, Fan YT, Li L, Qiu YY, Wang ZC, Han S, Yin J, Liu WH, Peng BW*, He XH*. Hyperthermia-induced seizures: Development of hyperthermia-prone and hyperthermia-resistant rats. Epilepsy Res. 2013,106(3):311-317 8. Li Z, Liu WH, Han S, Peng BW, Yin J, Wu YL*, He XH*, Li WX. Selective Inhibition of CCR7_ Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model. J Biol Chem. 2012, 287(35):29479-29494 9. He Y, Wu Q, Xu ZP, Wang QQ, Wang WL, Li DZ, Liu WH*, He XH*. Hereditary Neuropathy with Liability to Pressure Palsy: An Investigation in a Rare and Large Chinese Family. Eur Neurol. 2012, 68:322-328 10. Wang ZH, Yang B, Dong LL, Peng BW, He XH*, Liu WH*. A novel oncoprotein Pirh2: rising from the shadow of MDM2. Cancer Sci. 2011,102:909-917 11. Yu F, Liu YL, Wang YC, Yin J, Wang H, Liu WH, Peng BW*, He XH*. Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures. Epilepsy Res. 2011,97:64-72 12. Han S, Hu YT, Zhang RH, Yi H, Wei JJ, Wu YL, Cao ZJ, Li WX, He XH*. ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates. Toxicon. 2011, 57:348-355 13. Zhang YY, Liu YJ, Zhu GG, Qiu YY, Peng BW, Yin J, Liu WH*, He XH*. Foamy virus: an available vector for gene transfer in neural cells and other non-dividing cells. J NeuroVirol. 2010, 16:419-426 14. He XH, Sullivan E, Stankovic R, Harper C, Pfefferbaum A. Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultra structure. Neuropsychopharmacology. 2007, 32: 2207-2216 15. Liu WH, Liu ZC, Cao XB, Cao ZJ, Xue L, Zhu F, He XH*, Li WX*. Recombinant human foamy virus, a novel vector for neurological disorder gene therapy, drive production of GAD in cultured astrocytes. Mol Ther. 2007, 15: 1834-1841