学习经历 1987 年 - 1992 年，就读于中国科学技术大学生物系，获学士学位。 1992 年 - 1995 年，在中国科学技术大学生物系深造，获硕士学位。 1995 年 - 1998 年，于复旦大学遗传学研究所攻读博士学位，获博士学位。 主要工作经历与任职情况 1998 年 - 1999 年，在美国佛蒙特大学（University of Vermont）医学院从事博士后研究工作。 1999 年 - 2006 年，在美国宾夕法尼亚大学（University of Pennsylvania）医学院，先后担任博士后和研究助理。 2006 年 - 至今，担任武汉大学生命科学学院教授。 2010 年 - 2012 年，被评为湖北省楚天学子。

一些种类的真菌在碱性pH、高温、氮源缺乏等条件下能够从椭圆形的酵母形态转换成为菌丝或假菌丝，被称为二型性转换（dimorphic transition）。二型性转换被认为是真菌应对环境压力的一种反应，它也是某些致病性真菌的毒力因子之一。解脂耶氏酵母Yarrowia lipolytica是一种在进化上与酿酒酵母和白色念珠菌亲缘关系较远而与丝状真菌更为接近的酵母种类，对人无致病性，它具有强大的降解烷烃、脂肪酸和油脂的能力，在发酵工业中具有良好的应用前景。解脂耶氏酵母在葡萄糖等碳源存在时、碱性pH、低氧等条件下能够从椭圆形的酵母形态转换为菌丝或假菌丝，我们的研究兴趣是寻找参与调控解脂耶氏酵母二型性转换的基因，探索其作用机制，以增进对真菌二型性转换调控机制的认识。

发表的论文（*通讯作者） 1. Shu T, He X-Y, Chen J-W, Mao Y-S, Gao X-D* (2021) The pH-responsive transcription factors YlRim101 and Mhy1 regulate alkaline pH-induced filamentation in the dimorphic yeast Yarrowia lipolytica. mSphere 6(3): e00179-21. 2. Zhu J, Jia Z-W, Xia C-Y, Gao X-D* (2020) The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast. Fungal Genet. Biol. 144: 103467. 3. Jia Z-W, Lv S-X, Zhu J, Xia C-Y, Gao X-D* (2020) Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth. Curr. Genet. 66(6): 1101-1115. 4. Wu H, Shu T, Mao Y-S, Gao X-D* (2020) Characterization of the promoter, downstream target genes and recognition DNA sequence of Mhy1, a key filamentation-promoting transcription factor in the dimorphic yeast Yarrowia lipolytica. Curr. Genet. 66(1): 245-261. 5. Nie W-C, He F, Yuan S-M, Jia Z-W, Wang R-R, Gao X-D* (2017) Roles of an N-terminal coiled-coil-containing domain in the localization and function of Bem3, a Rho GTPase-activating protein in budding yeast. Fungal Genet. Biol. 99: 40-51. 6. Liang S-H, Wu H, Wang R-R, Wang Q, Shu T, Gao X-D* (2017) The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica. Mol. Microbiol. 104(4):553-567. 7. Yuan S-M, Nie W-C, He F, Jia Z-W, Gao X-D* (2016) Kin2, the budding yeast ortholog of animal MARK/PAR-1 kinases, localizes to the sites of polarized growth and may regulate septin organization and the cell wall. PLoS ONE 11(4): e0153992. 8. Wu H, Guo J, Zhou Y-T, Gao X-D* (2015) The anillin-related region of Bud4 is the major functional determinant for Bud4’s function in septin organization during bud growth and axial bud-site selection in budding yeast. Eukaryot. Cell 14(3): 241-251. 9. He F, Nie W-C, Tong Z, Yuan S-M, Gong T, Liao Y, Bi E, Gao X-D* (2015) The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. PLoS ONE 10(4): e0123326. 10. Li Y-Q, Li M, Zhao X-F, Gao X-D* (2014) A role for the Rap GTPase YlRsr1 in cellular morphogenesis and the involvement of YlRsr1 and the Ras GTPase YlRas2 in bud-site selection in the dimorphic yeast Yarrowia lipolytica. Eukaryot. Cell 13(5): 580-590.