学习经历 1990.09 - 1994.06，武汉大学生命科学学院，微生物专业，获学士学位。 2000.09 - 2003.06，武汉大学生命科学学院，生物物理专业，获硕士学位。 2003.09 - 2006.12，武汉大学生命科学学院，微生物专业，获博士学位。 主要工作经历与任职情况 1994.07 - 2000.08，湖北中医药大学基础医学院（原湖北中医学院基础部），担任助教。 2007.02 - 2009.11，武汉大学生命科学学院，担任讲师。 2009.11 - 2022.11，武汉大学生命科学学院，担任副教授。 2012.01 - 2012.12，美国纽约州奥尔巴尼医学院，作为访问学者。 2020.08 - 2023.12，在西藏大学理学院 / 生态环境学院（援藏），担任副院长，期间职称由副教授升为教授。 2022.11 - 至今，武汉大学生命科学学院，担任教授。

1.　肿瘤发生发展机制研究 2.　细胞外囊泡（外泌体）在肿瘤诊断治疗中的功能与应用基础研究 3.　青藏高原特色藏药材和微生物资源调查及其保护利用研究

主要研究论文（#Co-first author，*Corresponding author，按发表时间排序） 1. Jiaqi Liu#, Yuting Sun#, Xianhuang Zeng#, Yang Liu, Chaozhi Liu, Ying Zhou, Yueguang Liu, Guihong Sun*, Mingxiong Guo*. Engineering and Characterization of an Artificial Drug-carrying Vesicles Nanoplatform for Enhanced Specifically Targeted Therapy of Glioblastoma. Advanced Materials, 2023, 35(41): 2303660. 2. Yi Liu, Wei Yin, Xianhuang Zeng, Jinhao Fan, Chaozhi Liu, Mingyu Gao, Zan Huang, Guihong Sun, Mingxiong Guo*. TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling. Journal of Biological Chemistry, 2023, 299(12): 105428. 3. Sen Yuan#, Jiaqi Xu#, Min Wang#, Junsong Huang, Shuangshuang Ma, Yang Liu, Yujia Ke, Xianhuang Zeng, Kangwei Wu, Jingwen Wang, Xuezhang Tian, Dandan Zheng, Tanzeel Yousaf, Wajeeha Naz, Junwei Sun, Lang Chen, Deyin Guo, Mingxiong Guo*, Guihong Sun*. HBV X protein induces degradation of UBXN7, a novel negative regulator of NF-κB signaling, to promote HBV replication. Cellular and Molecular Gastroenterology and Hepatology, 2023, 15(1): 179-195. 4. Xianhuang Zeng, Chaozhi Liu, Jinhao Fan, Jiabin Zou, Mingxiong Guo*, Guihong Sun*. RNF138 downregulates antiviral innate immunity by inhibiting IRF3 activation. International Journal of Molecular Sciences, 2023, 24(22), 16110. 5. Chuang Li, Wei Wang, Yuting Sun, Yifan Ni, Fang Qin, Xiaolu Li, Tao Wang, Mingxiong Guo*, Guihong Sun*. Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression. Journal of Experimental & Clinical Cancer Research, 2022, 41(1), 136. 6. Yang Liu#, Jingwen Wang#, Jianwen Chen#, Shaoshuai Wu#, Xianhuang Zeng, Qiushuang Xiong, Yandan Guo, Junwei Sun, Feifei Song, Zhepeng Liu, Fengxing Huang, Jiaqi Xu, Sen Yuan, Chuang Li, Shuting Guo, Ming Wang, Kun Li, Lang Chen, Yun-Bo Shi, Mingxiong Guo*, Deyin Guo*, Guihong Sun*. Upregulation of miR-520c-3p by HBV Enhances Tumor Cell Migration and Invasion by Activating NF-κB Signaling via PTEN-AKT Pathway. Molecular Therapy-Nucleic Acids, 2022, 29: 47-63. 7. Chuang Li#, Fang Qin#, Wei Wang, Yifan Ni, Mingyu Gao, Mingxiong Guo*, and Guihong Sun*. hnRNPA2B1-mediated extracellular vesicles sorting of miR-122-5p potentially promotes lung cancer progression. International Journal of Molecular Sciences, 2021, 22(23), 12866. 8. Chuang Li, Fang Qin, Mengmeng Xue, Yucong Lei, Fen Hu, Hui Xu, Guihong Sun, Tao Wang*, Mingxiong Guo*. miR-429/-424-5p inhibit cell proliferation and Ca2+ influx by targeting CASR in pulmonary artery smooth muscle cells. American Journal of Physiology-Cell Physiology, 2019, 316(1): C111-C120. 9. Yi Liu, Wei Yin, Jingwen Wang, Yucong Lei, Guihong Sun, Wenxin Li, Zan Huang*, Mingxiong Guo*. KRAB-zinc finger protein ZNF268a deficiency attenuates the virus-induced pro-inflammatory response by preventing IKK complex assembly. Cells-Basel, 2019, 8, 1604. 10. Jingwen Wang, Jianwen Chen, Yang Liu, Xianhuang Zeng, Mingcong Wei, Shaoshuai Wu, Qiushuang Xiong, Feifei Song, Xu Yuan, Yu Xiao, Yun Cao, Changyong Li, Lang Chen, Mingxiong Guo, Yun-Bo Shi, Guihong Sun, Deyin Guo. Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP Through NF kappa B Signaling. Hepatology. 2019, 69(3): 974-992.