樊利芳 照片

樊利芳

副教授 硕导

所属大学: 武汉大学

所属学院: 基础医学院

邮箱:
lifangfan@whu.edu.cn

个人主页:
https://wbm.whu.edu.cn/info/1131/3635.htm

个人简介

6、学习经历: 2000.9~2003.6 武汉大学基础医学院病理学硕士 2005.9~2008.11 武汉大学第一临床学院内科学博士 2009.7-2010.7 美国Cedars Sinai Medical Center 访问学者 2015.3-8月 华西医院病理科学习 7、主要工作经历与任职: 2003.07~2006.11 武汉大学基础医学院病理教研室 助 教 2006.11~2010.11 武汉大学基础医学院病理教研室 讲 师 2010.11~至今 武汉大学基础医学院病理教研室 副教授

研究领域

主要研究方向为消化道肿瘤的发生发展机制,对近年肿瘤发生的新理论—肿瘤干细胞理论进行过相关研究,发现小肠及结直肠腺癌中干细胞基因musashi-1,survivn等基因过表达,化疗药奥沙利铂可杀死终末分化的肿瘤细胞,而由于肿瘤干细胞具有耐药的特性,使得化疗药物处理后,肿瘤干细胞相对富集,干细胞基因表达水平升高。

近期论文

1. Wang Y, Jiang CQ, Fan LF*. Correlation of Musashi-1, Lgr5 and pEGFR expressions in human small intestinal adenocarcinomas. Tumor Biol. 2015, Mar 14. [Epub ahead of print] 2. Yan Wan, Cong-Qing Jiang , Jing Guan ,Gui-Fang Yang, Jun-Qiu Yue,Hong-Lei Chen , Jing-Ling Xue, Zhi-Gao Xu, Qun Qian, Li-Fang Fan*.Molecular alterations of EGFR in small intestinal adenocarcinoma. Int J Colorectal Dis. 2013; 28(10):1329-1335. 3. Fan Lifang, Wang Yan, Tian Sufang, Diao Luming, Zhang Qiuping, Hu Suping. exploration and thinking of Chichago University educational reform in pathology teaching. China Higher Medical Education,2015: 4. 4. Yi Zhang, Xue Yao, Congqing Jiang, Junqiu Yue, Jing Guan, Honglei Cheng, Mohammed Hajirashid, Yan Wang, Li-Fang Fan*. Expression of PI3K, PTEN and Akt in small intestinal quantum dots-based immunofluorescence technology. Cancer Biomark.2013; 13(4)299-305. 5. Fan L, Levy M, Aguilar CE, Mertens RB, Dhall D, Frishberg DP, Wang HL. Lymph node retrieval from colorectal resection specimens for adenocarcinoma: is it worth the extra effort to find at least 12 nodes? Colorectal Dis. 2011; 13(12):1377-1383. 6. Fan LF, Datta V, Riley-Portuges, Lopategui J, Lin F, Xu HD, Wang HL. EGFR Expression and KRAS Mutation in Cholangiocarcinoma: Implication in EGFR-Targeted Therapie. Mod Pathol. 2010; 23 Supplement, 354A. 7. Fan LF, Mylinh TM, Frishberg DP, Fan X, Dhall D, Bonnie LB, Geller SA, Wang HL. Interobserver and Intraobserver Variability in Evaluating Vascular Invasion in Hepatocellular Carcinoma. J Gastroenterol Hepatol. 2010; 25(9):1556-15561. 8. Fan LF, Dong WG, Jiang CQ, Xia D, Liao F, Yu QF. Expression of putative stem cell genes musashi-1, and β1-integrin in human colorectal adenomas and adenocarcinoma. Int J Colorectal Dis. 2010; 25(1): 17-23.