教育经历 1992 年 - 1996 年，就读于华中农业大学，专业为土壤与植物营养，获得学士学位。 1996 年 - 2002 年，在华中农业大学深造，专业为微生物学，取得博士学位。 工作经历 2002 年 - 2005 年，于法国里昂第一大学感染与免疫学系从事博士后研究工作。 2005 年 - 2009 年，在美国克利夫兰临床医院分子遗传学系担任博士后职位。 2009 年 - 至今，担任武汉大学生命科学学院病毒学国家重点实验室教授。

我们长期致力于呼吸道病毒和肠道病毒复制、感染与致病机制研究及新型疫苗研发，综合运用包括病毒学、细胞生物学和活细胞荧光技术在内的多学科实验系统，解析病毒在宿主细胞内复制、组装、释放及病毒与宿主细胞的相互作用过程，同时也探讨病毒诱导并逃逸/劫持细胞的抗病毒反应（如自噬和应激颗粒反应等）过程，为阐明病毒感染和致病的分子机制及鉴定有效抗病毒药物靶点奠定了基础。经过近十年的发展，我们已取得了一系列原创性、系统性成果。包括：1）系统阐明了病毒聚合酶和核心蛋白相互作用能够形成一种特殊的结构-包涵体，它担负病毒RNA合成的新功能；2）深入研究了病毒基质蛋白调节病毒粒子组装和释放的新机制；3）发现病毒基质蛋白和聚合酶协同调节/劫持细胞自噬过程，从而最大限度增强病毒的复制和感染能力；4）解析了病毒逃逸宿主细胞应激颗粒抗病毒反应的分子机制，提出弱化病毒复制和感染的新策略。

代表性论文（＊为通讯作者） 1) Li Z, Guo D, Qin Y*,Chen M*. PI4KB on inclusion bodies formed by ER membrane remodeling facilitates replication of human parainfluenza virus type 3.Cell Reports. Nov 19; 29(8):2229-2242 2) Zhang Q#, Sharma N#, Zheng Z*,Chen M*. Viral Regulation of RNA Granules in Infected Cells.Virol Sin. 2019 Apr;34(2):175-191. 3) Tang Q, Liu P,Chen M*, Qin Y*. 2019. Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3.Viruses. May 15;11(5). 4) Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y,Chen M*.2019. SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists.Cell Discov. eCollection. 5) Zhang L, Qin Y,Chen M*.2018. Viral strategies for triggering and manipulating mitophagy.Autophagy. 14(10):1665-1673. 6) Zhang S#, Cheng Q#, Luo C, Qin Y*,Chen M*.2018. Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation.Viruses. 11;10(3). 7) Hu Z, Wang Y, Tang Q, Yang X, Qin Y,Chen M*.2018. Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs.PLoS Pathog14(3): e1006948. 8) Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y,Chen M*.2018Picornavirus 2A protease regulates stress granule formation to facilitate viral translation.PLoS Pathog14(2): e1006901. https://doi.org/10.1371/journal.ppat.1006901. 9) Zhang S#, Cheng Q#, Luo C, Yin L, Qin Y*,Chen M*.2018. An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N0-P interaction and maintaining N solubility.Virology. 518:64-76. 10) Ding B#, Zhang L#, Li Z, Zhong Y, Tang Q, Qin Y,Chen M*. 2017. The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.Cell Host Microbe. 21(4):538-547. 11) Zhang S#, Jiang Y#, Cheng Q, Zhong Y, Qin Y,Chen M*. 2017. Inclusion body fusion of human parainfluenza virus type 3 regulated by acetylated α-tubulin enhances viral replication.Journal of Virology. 91(3). pii: e01802-16. 12) Jiang Y, Qin Y*,Chen M*. 2016. Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.Viruses, 8 (11), E308 (Invited review). 13) Yan Q#, Wu L#, Chen L, Qin Y*, Pan Z*,Chen M*. 2016. Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particles elicit strong immune responses and protect newborn mice from lethal challenges.Vaccine. 34:4196-4204. 14) Zhang G#, Zhong Y#, Qin Y,Chen M*. 2015. Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly.Journal of Virology. 90(5):2306-15. 15) Ding B, Qin Y,Chen M*. 2016. Nucleocapsid proteins: roles beyond viral RNA packaging.WIREs RNA. 7(2):213-26. (Invited review). 16) Chen L, Zhong Y, Hu Z, Qin Y. Chen M.Chen M*. 2016. Two second-site mutations compensate the engineered mutation of R7A in vesicular stomatitis virus nucleocapsid protein.Virus Research, 214:59-64. 17) Chen L#, Yan Q#, Lu G, Hu Z, Zhang G, Zhang S, Ding B, Jiang Y, Zhong Y, Gong P,Chen M*. 2015. Several residues within the N-terminal arm of vesicular stomatitis virus nucleoprotein play a critical role in protecting viral RNA from nuclease digestion.Virology.478:9-17. 18) Ding B, Zhang G, Yang X, Zhang S, Chen L, Yan Q, Xu M, Banerjee AK,Chen M*. 2014. Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production.Cell Host & Microbe.15(5):564-77. 19) Zhang G, Zhang S, Ding B, Yang X, Chen L, Yan Q, Jiang Y, Zhong Y,Chen M*. 2014. A Leucine Residue in C-terminus of Human Parainfluenza Virus Type 3 Matrix Protein Is Essential for Efficient Virus-Like Particle and Virion Release.Journal of Virology. 88(22):13173-88.