个人简介
教育背景: 1994.9 - 1999.6,湖北医科大学临床医学系,学士 1999.9 - 2002.6,武汉大学医学院,药理学硕士 2005.9 - 2010.6,华中科技大学同济医学院公共卫生学院,劳动卫生与环境卫生专业医学博士 2007.10 - 2009.9,德国图宾根大学医学院脑科研究所,DAAD 奖学金博士研究生 工作经历: 2002.6 - 2012.6,华中科技大学同济医学院药学院,助教 / 讲师 2012.7 - 2014.7,日本北海道大学齿学院,JSPS 特别研究员 2014.10 - 至今,武汉大学基础医学院药理学系,教授 2016.12 - 2017.05,日本京都大学大学院人間・環境学研究科,访问教授
研究领域
探索纳米材料与生物机体的相互作用及其细胞分子机制;将纳米材料/药物用于人类疾病的诊断与治疗。当前兴趣:纳米药物递送系统调控肿瘤免疫微环境以及用于肿瘤的免疫治疗。
近期论文
1. TF Li, YH Xu, K Li, C Wang, X Liu, Y Yue, Z Chen, SJ Yuan, Y Wen, Q Zhang, M Han, N Komatsu, L Zhao*, X Chen*. Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy. Acta Biomater. 2019; In press (IF: 6.38) 2. Z Chen, C Wang, TF Li, K Li, Y Yue, X Liu, HZ Xu , Y Wen, Q Zhang, M Han, N Komatsu, YH Xu, L Zhao*, X Chen*. Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates. Nanomedicine (Lond). 2018; In press. (IF: 5.008) 3. Li TF, Li K, Zhang Q, Wang C, Yue Y, Chen Z, Yuan SJ, Liu X, Wen Y, Han M, Komatsu N, Xu YH, Zhao L*, Chen X*. Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma. Biomaterials. 2018;181:35-52. (IF: 8.806) 4. Li TF, Li K, Wang C, Liu X, Wen Y, Xu YH, Zhang Q, Zhao QY, Shao M, Li YZ, Han M, Komatsu N, Zhao L*, Chen X*. Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment. J Control Release. 2017;268:128-146. (IF:7.877) 5. Wang C, Li K, Li T, Chen Z, Wen Y, Liu X, Jia X, Zhang Y, Xu Y, Han M, Komatsu N, Zhao L*, Chen X*. Monocyte-mediated chemotherapy drug delivery in glioblastoma. Nanomedicine (Lond). 2018;13 (2):157-178. (IF: 5.008) 6. ZJ Wang, YH Xu, XN Meng, F Watari, HD Liu*, X Chen*, Suppression of c-Myc is involved in multi-walled carbon nanotubes' down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells. Toxicol Appl Pharm. 2015;282(1):42-51.(IF 3.63) 7. L. Zhao, Y. Xu, H. Qin, S. Abe, T. Akasaka, T. Chano, F. Watari, T. Kimura, N. Komatsu*, X. Chen*. Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting peptide, and Acid-Responsive Antitumor Drug. Adv Funct Mater. 2014; 24(34): 5348–5357. (IF 10.439) 8. L. Zhao, Y. Xu, S. Abe, T. Akasaka, T. Watari, T. Kimura, N. Komatsu, X. Chen*. Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells. Biomaterials. 2014; 35(20): 5393–5406.(IF: 8.321)