学习经历 本科阶段：1999 年 9 月至 2003 年 6 月，在武汉大学生命科学学院生物技术系就读本科。 博士阶段 2003 年 9 月至 2009 年 6 月，于武汉大学生命科学学院攻读病毒学方向博士。 2005 年 7 月至 2006 年 7 月，在芬兰赫尔辛基大学生物技术研究所进行联合培养。 主要工作经历与任职情况 2009 年 9 月至 2011 年 10 月，任武汉大学生命科学学院讲师。 2011 年 11 月至 2016 年 10 月，任武汉大学生命科学学院副教授。 2016 年 11 月至今，任武汉大学生命科学学院教授。

医学病毒学，冠状病毒及抗病毒研究

发表的论文（#并列第一作者，*通讯作者） 1. Ma C#, Chen X#, Mei F#, Xiong Q, Liu Q, Dong L, Liu C, Zou W, Zhan F, Hu B, Liu Y, Liu F, Zhou L, Xu J, Jiang Y, Xu K, Cai K*, Chen Y*, Yan H*, Lan K* , Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg Microbes Infect. 2022;11(1):567-72. 2. Liu Q#, Xiong Q#, Mei F#, Ma C, Zhang Z, Hu B, Xu J, Jiang Y, Zhan F, Zhou S, Tao L, Chen X, Guo M, Wang X, Fang Y, Shen S, Liu Y, Liu F, Zhou L, Xu K, Ke C, Deng F, Cai K*, Yan H*, Chen Y*, Lan K*, Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China. Innovation (N Y). 2022;3(1):100181. 3. Pan R#, Kindler E#, Cao L#, Zhou Y, Zhang Z, Liu Q, Ebert N, Züst R, Sun Y, Gorbalenya AE, Perlman S*, Thiel V*, Chen Y*, Guo D*,N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition. mBio. 2022;13(1):e0366221. 4. Yan H#, Jiao H#, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K*, Chen Y*, Zhao H*, ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nature ecology & evolution. 2021;5(5):600-8. （ESI高被引论文） 5. Wang D#, Jiang A#, Feng J#, Li G#, Guo D#, Sajid M, Wu K, Zhang Q, Ponty Y, Will S, Liu F, Yu X, Li S, Liu Q, Yang XL, Guo M, Li X, Chen M, Shi ZL, Lan K*, Chen Y*, Zhou Y*,The SARS-CoV-2 subgenome landscape and its novel regulatory features. Molecular cell. 2021;81(10):2135-47.e5. 6. Zhang Z#, Liu Q#, Sun Y, Li J, Liu J, Pan R, Cao L, Chen X, Li Y, Zhang Y, Xu K, Guo D, Zhou L, Lan K, Chen Y*,Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice. Emerg Microbes Infect. 2021;10(1):1626-37. 7. Xiong Y#, Liu Y#, Cao L#, Wang D#, Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Liu Y, Zhou Y*, Lan K*, Chen Y*,Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerg Microbes Infect. 2020;9(1):761-70.（ESI高被引论文） 8. Suo T#, Liu X#, Feng J#, Guo M#, Hu W#, Guo D, Ullah H, Yang Y, Zhang Q, Wang X, Sajid M, Huang Z, Deng L, Chen T, Liu F, Xu K, Liu Y, Zhang Q, Liu Y, Xiong Y*, Chen G*, Lan K*, Chen Y*,ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens. Emerg Microbes Infect. 2020 Dec;9(1):1259-1268.（ESI高被引论文） 9. Liu, Yuan#; Ning, Zhi#*; Chen, Yu#*; Guo, Ming#; Liu, Yingle; Gali,Nirmal Kumar; Sun, Li; Duan, Yusen; Cai, Jing; Westerdahl, Dane; Liu, Xinjin;Xu, Ke; Ho, Kin-fai* ; Kan, Haidong* ; Fu, Qingyan* ; Lan, Ke*, Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. 2020 Jun;582(7813):557-560.（ESI高被引论文） 10. Chen L#, Liu W#, Zhang Q#, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y*, Li Y*, Shi M*, Lan K*, Liu Y*,RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerg Microbes Infect. 2020 Feb 5;9(1):313-319.（ESI高被引论文） 11. Chen Y*, Liu Q, Guo D*,Emerging coronaviruses: Genome structure, replication, and pathogenesis. J Med Virol. 2020;92(4):418-23.(ESI高被引论文） 12. Liu X#, Feng J#, Zhang Q#, Guo D#, Zhang L, Suo T, Hu W, Guo M, Wang X, Huang Z, Xiong Y, Chen G*, Chen Y*, Lan K*,Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets. Emerg Microbes Infect. 2020;9(1):1175-9. 13. Cao L, Ji Y, Zeng L, Liu Q, Zhang Z, Guo S, Guo X, Tong Y, Zhao X, Li CM, Chen Y*, Guo D*, P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus. PLoS Pathog. 2019;15(10):e1008079. 14. Gui M, Liu X, Guo D, Zhang Z, Yin CC*, Chen Y*, Xiang Y*,Electron microscopy studies of the coronavirus ribonucleoprotein complex. Protein & cell. 2017;8(3):219-24. 15. Chen Y*, Guo D*, Molecular mechanisms of coronavirus RNA capping and methylation. Virol Sin. 2016;31(1):3-11. 16. Cui L, Wang H, Ji Y, Yang J, Xu S, Huang X, Wang Z, Qin L, Tien P, Zhou X, Guo D*, Chen Y*. The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells. J Virol. 2015;89(17):9029-43. 17. Liu X#, Hao R#, Chen S, Guo D, Chen Y*. Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome. The Journal of general virology. 2015;96(8):2252-2261. 18. Wang Y#, Sun Y#, Wu A, Xu S, Pan R, Zeng C, Jin X, Ge X, Shi Z, Ahola T, Chen Y*, Guo D*. Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis. J Virol. 2015;89(16):8416-27. 19.Wu A, Wang Y, Zeng C, Huang X, Xu S, Su C, Wang M, Chen Y*, Guo D*. Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus. Virus Res. 2015;208:56-65.