学习经历 1981 年 - 1985 年，武汉大学生物系微生物学专业，获学士学位。 1985 年 - 1988 年，武汉大学生物系微生物学专业，获硕士学位。 1996 年 - 2002 年，武汉大学生命科学学院遗传学专业（在职），获博士学位。 主要工作经历与任职情况 1988 年 - 1991 年，武汉大学生物系，担任助教。 1991 年 - 1997 年，武汉大学生命科学学院，担任讲师。 1997 年 - 2004 年，武汉大学生命科学学院，担任副教授。 2004 年 - 至今，武汉大学生命科学学院，担任教授。 2011 年起，任中国典型培养物保藏中心副主任。 2017 年起，任中国典型培养物保藏中心主任。

微生物遗传学

1. Zhao Chen , Ying Liu, Yixuan Wang , Xincheng Du , Xiaoyuan Deng, Jialin Xiang , Yangyang Wang , Jiao Wang , Mart Krupovic, Shishen Du*, Xiangdong Chen*. A virus-borne DNA damage signaling pathway controls the lysogeny-induction switch in a group of temperate pleolipoviruses. Nucleic Acids Res. 2023 Apr 24;51(7):3270-3287. doi: 10.1093/nar/gkad125. PMID: 36864746; PMCID: PMC10123103. 2. Liping Deng, Chao Wang 1, Xiaoming Zhang, Wenjie Yang, Hao Tang , Xinru Chen , Shishen Du*, Xiangdong Chen*. Cell-to-cell natural transformation in Bacillus subtilis facilitates large scale of genomic exchanges and the transfer of long continuous DNA regions.Nucleic Acids Res. 2023 May 8;51(8):3820-3835. doi: 10.1093/nar/gkad138. PMID: 36912090; PMCID: PMC10164588. 3. Li Xu , Ying Zhou, ZhiChun Zhan , Wei Zhang , DaBo Fu , Rui Zhao , Xiangdong Chen*. Research Note: Effects of Bacillus coagulans X26 on the production performance, intestinal structure, short-chain fatty acids and flora composition of laying hens during the peak laying period. Poult Sci. 2022 Jun;101(6):101835. doi: 10.1016/j.psj.2022.101835. Epub 2022 Mar 9. PMID: 35398755; PMCID: PMC9006320.. 4. 宋珊珊、邓晓园、杜鑫成、欧阳淑珊、陈向东*. 极端嗜盐多形性古菌病毒HRPV13的分离鉴定及生物学特性，微生物学通报, 2022, 49(5): 1563-1580 5. Beibei Chen, Zhao Chen, Yuchen Wang, Han Gong, Linshan Sima, Jiao Wang, Shushan Ouyang, Wenqiang Gan, Mart Krupovic, Xiangdong Chen*, Shishen Du* ORF4 of the Temperate Archaeal Virus SNJ1 Governs the Lysis-Lysogeny Switch and Superinfection Immunity. J Virol. 2020 Jul 30;94(16):e00841-20. doi: 10.1128/JVI.00841-20. PMID: 32522850; PMCID: PMC7394903. 6. Qinggong Guo, Beibei Chen, Yishuai Tu, Shishen Du* and Xiangdong Chen * Prophage LambdaSo uses replication interference to suppress reproduction of coexisting temperate phage MuSo2 in Shewanella oneidensis MR-1. Environ Microbiol . 2019 Jun;21(6):2079-2094. doi: 10.1111/1462-2920.14592. Epub 2019 Mar 28. PMID: 30882982. 7. Yunqian Qiao, Jiao Wang, He Wang, Baozhong Chai, Chufeng Rao, Xiangdong Chen*, Shishen Du* 4-hydroxyphenylpyruvate dioxygenase thermolability is responsible for temperature-dependent melanogenesis in Aeromonas salmonicida subsp. Salmonicida. Appl. Environ, Microbiol. 2018 Dec 13;85(1):e01926-18. doi: 10.1128/AEM.01926-18. PMID: 30341077; PMCID: PMC6293093. 8. Xiaoming Zhang, Tingting Jin, Liping Deng, Chao Wang, Yuhua Zhang, Xiangdong Chen * Stress-Induced, Highly Efficient, Donor Cell-Dependent Cell-to-Cell Natural Transformation in Bacillus subtilis . J Bacteriol . 2018 Aug 10;200(17):e00267-18. doi: 10.1128/JB.00267-18. PMID: 29941421; PMCID: PMC6088163. . 9. Ruili Zhao, Rui Zhao, Yishuai Tu, Xiaoming Zhang, Liping Deng, Xiangdong Chen * A novel α-galactosidase from the thermophilic probiotic Bacillus coagulans with remarkable protease-resistance and high hydrolytic activity. PLoS ONE . 2018 May 8;13(5):e0197067. doi: 10.1371/journal.pone.0197067. PMID: 29738566; PMCID: PMC5940202. 10. Jiao Wang, Yingchun Liu, Ying Liu, Kaixin Du, Shuqi Xu, Yuchen Wang, Mart Krupovic, Xiangdong Chen* A novel family of tyrosine integrases encoded by the temperate pleolipovirus SNJ2. Nucleic Acids Res. 2018 Mar 16;46(5):2521-2536. doi: 10.1093/nar/gky005. PMID: 29361162; PMCID: PMC5861418 . 11. Yuchen Wang, Beibei Chen, Mengzhuo Cao, Linshan Sima, David Prangishvili, Xiangdong Chen*, Mart Krupovic* Rolling-circle replication initiation protein of haloarchaeal sphaerolipovirus SNJ1 is homologous to bacterial transposases of the IS91 family insertion sequences. J Gen., Virol. 2018 Mar;99(3):416-421. doi: 10.1099/jgv.0.001009. PMID: 29458508.