教育背景及工作经历 2003.09-2007.06 华东理工大学 制药工程学士学位 2007.09-2012.06 中国科学院上海有机化学研究所 有机化学博士学位 导师：刘国生研究员 2012.07-2013.06 药明康德新药研发有限公司 高级研究员 2013.07-2017.06 瑞士洛桑联邦理工大学 博士后导师：Xile HU 教授 2017.07-2018.06 同济大学高等研究院 特聘研究员 2018.07-至今 同济大学化学科学与工程学院 教授 荣誉与奖励 2018 上海市浦江人才 2018 国家青年人才计划

金属催化反应及不对称催化 生物酶模拟及气体的活化转化反应 活性药物小分子的设计与开发

Photoinduced Radical Addition Process Enabled Deoxygenative Hydroacylation and Hydrophosphonylation of Carbonyls Xiaoqiang Wu, Jun Zhou, Zihao Hu, and Tao XU* Chem Catalysis 2024, 4, accepted. Formal Deoxygenative Cross-Coupling of Aldehydes to Ketones through α-Haloboronates: A Route to Deoxygenative Hydroacylation of Aldehydes Zihao Hu, Wanqi Zhang, and Tao XU* Chinese Journal of Chemistry 2023, 41, 3593-3597. Nickel-Catalyzed Regio- and Enantioselective Borylative Coupling of Terminal Alkenes with Alkyl Halides (Invited Highlight) Hepan Wang, and Tao XU* Chinese Journal of Organic Chemistry 2023, 43, 3328-3330. Synthesis of Chiral Allylic Phosphonates via Asymmetric Reductive Cross-Coupling of α-Bromophosphonates and Vinyl Bromides Hepan Wang, Xinxuan Li, and Tao XU* Science China Chemistry 2023, 66, 2621-2625. Cross-Coupling of Aldehydes and α-Bromophosphonates to Modularly Access α-Substituted-β-Ketophosphonates Under Dual Nickel/Photoredox Catalysis Xinxuan Li‡, Hepan Wang‡, and Tao XU* (‡equal contribution) Organic Chemistry Frontiers 2023, 10, 3061-3066. Selectively Tunable Synthesis of α-Trifluoromethyl Ketones Pan Zhou, Shanya Lu, Xiaoqiang Wu, Wei Zhong*, and Tao XU* Organic Letters 2023, 25, 2344-2348. Enantioconvergent Reductive C(sp)-C(sp3) Cross-Coupling to Access Chiral α-Alkynyl Phosphonates Under Dual Nickel/Photoredox Catalysis (Hot Paper) Hepan Wang, Xiaoqiang Wu, and Tao XU* Angewandte Chemie International Edition 2023, 62, e202218299. Recent Advances on The Preparation and Asymmetric Transformation of α-Haloboron Compounds Dong Wang, and Tao XU* Synlett 2023, 34, 2085-2096. Enantioselective C(sp3)-C(sp3) Reductive Cross-Electrophile Coupling of Unactivated Alkyl Halides with α-Chloroboronates via Dual Nickel/Photoredox Catalysis Jun Zhou, Dong Wang, Wenhao Xu, Zihao Hu, and Tao XU* Journal of the American Chemical Society 2023, 145, 2081-2087. Deoxygenative Alkylboration of Aldehydes to Synthesize Versatile Secondary α,α-Dialkyl Boronates (Synpacts) Wenhao Xu, Liejin Zhou*, and Tao XU* Synlett 2023, 34, 1075-1078. Deoxygenative Haloboration and Enantioselective Chloroboration of Carbonyls Dong Wang, Jun Zhou, Zihao Hu, and Tao XU* Journal of the American Chemical Society 2022, 144, 22870-22876. Deoxygenative Arylboration of Aldehydes via Copper and Nickel/Photoredox Catalysis Purui Zheng, Wenhao Xu, Hepan Wang, Dong Wang, Xiaoqiang Wu, and Tao XU* ACS Catalysis 2022, 12, 14926-14933. Modular and Fast Synthesis of Versatile Secondary α,α-Dialkyl Boronates via Deoxygenative Alkylboration of Aldehydes Wenhao Xu, Purui Zheng, Jun Zhou, Zihao Hu, and Tao XU* Angewandte Chemie International Edition 2022, 61, e202214213. Molybdenum-Catalyzed Cross-Coupling of Benzyl Alcohols: Direct C-OH Bond Transformation via [2+2]-Type Addition and Elimination Pan Zhou, Yuqiang Li*, and Tao XU* Organic Letters 2022, 24, 4218-4223. Modular and Facile Access to Chiral α-Aryl Phosphonates via Dual Nickel- and Photoredox-catalyzed Reductive Cross-Coupling Hepan Wang, Purui Zheng, Xiaoqiang Wu, Yuqiang Li*, and Tao XU* Journal of the American Chemical Society 2022, 144, 3989-3997. A Pivotal Role of Chloride Ion on Nickel-Catalyzed Reductive Cross-Coupling to Access Chiral Perfluoroalkylated Boronate Esters Dong Wang, and Tao XU* ACS Catalysis 2021, 11, 12469-12475. Dual Nickel- and Photoredox-Catalyzed Reductive Cross-Coupling to Access Chiral Trifluoromethylated Alkanes Pan Zhou, Xinxuan Li, Dong Wang, and Tao XU* Organic Letters 2021, 23, 4683-4687. Reductive Cross-Coupling to Access C-N Bond from Aryl Halides and Diazoesters under Dual Nickel/Photoredox-Catalyzed Conditions Xiaoqiang Wu, Purui Zheng, Wanfang Li*, and Tao XU* Organic Chemistry Frontiers 2021, 8, 4118-4123. Dual Ni/Photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters Purui Zheng, Pan Zhou, Dong Wang, Wenhao Xu, Hepan Wang, and Tao XU* Nature Communications 2021, 12, 1646. Dual Nickel- and Photoredox-Catalyzed Reductive Cross-Coupling of Aryl Halides with Dichloromethane via a radical process Wenhao Xu‡, Purui Zheng‡, and Tao XU* (‡equal contribution) Organic Letters 2020, 22, 8643-8647. A Novel Bisoxazoline-Imidazolium Salt in Ytterbium-Catalyzed Asymmetric Reduction of Ketone Yujie Zhai, Wenhao Xu, Dong Wang, Purui Zheng, Xiaoming Zhao*, and Tao XU* European Journal of Organic Chemistry 2020, 2020, 5025-5028. Nickel-catalyzed Intramolecular Desymmetrization Addition of Aryl Halides to 1,3-Diketones Pan Zhou, and Tao XU* Chemical Communications 2020, 56, 8194-8197. Enantioselective Copper-Catalyzed Desymmetrization of 1,3-Diketones Involving Borylation of Styrenes Purui Zheng, Xiaoyu Han, Jiao Hu, Xiaoming Zhao*, and Tao XU* Organic Letters 2019, 21, 6040-6044. Palladium-Catalyzed Cross-Coupling of gem-Bis(boronates) with Aryl Halides: An Alternative To Access Quaternary α-Aryl Aldehydes Purui Zheng, Yujie Zhai, Xiaoming Zhao*, and Tao XU* Organic Letters 2019, 21, 393-396. Difunctionalization of ketones via gem-bis(boronates) to synthesize quaternary carbon with high selectivity Purui Zheng, Yujie Zhai, Xiaoming Zhao*, and Tao XU* Chemical Communications 2018, 54, 13375-13378. A Water-bridged H-bonding network contributes to the catalysis of a SAM-dependent C-methyltransferase HcgC Liping Bai#, Tristan Wagner#, Tao Xu, Xile Hu, Ulrich Ermler, and Seigo Shima* Angewandte Chemie International Edition 2017, 56, 10806-10809. Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semi-synthetic hydrogenase Liping Bai, Takashi Fujishiro, Gangfeng Huang, Jürgen Koch, Atsushi Takabayashi, Makio Yokono, Ayumi Tanka, Tao Xu, Xile Hu, Ulrich Ermler, and Seigo Shima* Faraday Discussion 2017, 198, 37-58. Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer Tao Xu, Matthew D. Wodrich, Rosario Scopelliti, Clemence Corminboeuf, and Xile Hu* Proceedings of the National Academy of Sciences USA 2017, 114, 1242-1245. Identification of HcgC as SAM-Dependent Pyridinol Methyltransferase in [Fe]- Hydrogenase Cofactor Biosynthesis Takashi Fujishiro#, Liping Bai#, Tao Xu, Xiulan Xie, Michael Schick, Jörg Kahnt, Michael Rother, Xile Hu, Ulrich Ermler, and Seigo Shima* Angewandte Chemie International Edition 2016, 55, 9648-9651. A Functional Model of [Fe]-Hydrogenase Tao Xu, Chih-Juo Madeline Yin, Matthew D. Wodrich, Simona Mazza, Katherine M. Schultz, Rosario Scopelliti, and Xile Hu* Journal of the American Chemical Society 2016, 138, 3270-3273. Mechanistic Investigation on the Silver-Catalyzed Oxidative Intramolecular Aminofluorination of Alkynes Tao Xu, Yichen Wu, Zheliang Yuan, Hairong Guan, and Guosheng Liu* Organometallics 2016, 35, 1347-1349. A Novel Nickel Pincer Complex in the Active Site of Lactate Racemase Tao Xu, Gerald Bauer, and Xile Hu* ChemBioChem 2016, 17, 31-32. Reconstitution of [Fe]-hydrogenase using model complexes Seigo Shima*, Dafa Chen, Tao Xu, Matthew D. Wodrich, Takashi Fujishiro, Katherine M. Schultz, Jörg Kahnt, Kenichi Ataka, and Xile Hu* Nature Chemistry 2015, 7, 995-1002. Abnormal Mesoionic Carbene Silver Complex: Synthesis, Reactivity, and Mechanistic Insight on Oxidative Fluorination Qilun Liu, Zheliang Yuan, Hao-yang Wang*, Yang Li, Yichen Wu, Tao Xu, Xuebing Leng, Pinhong Chen, Yinlong Guo, Zhenyang Lin*, and Guosheng Liu* ACS catalysis 2015, 5, 6732-6737. Hydrogen-activating models of hydrogenases Tao Xu, Dafa Chen, and Xile Hu* Coordination Chemistry Reviews 2015, 303, 32-41. Copper-Catalyzed 1,2-Addition of α-Carbonyl Iodides to Alkynes Tao Xu, and Xile Hu* Angewandte Chemie International Edition 2015, 54, 1307-1311. Iron-catalyzed 1,2-Addition of Perfluoroalkyl Iodides to Alkynes and Alkenes Tao Xu, Chi Wai Cheung, and Xile Hu* Angewandte Chemie International Edition 2014, 53, 4910-4914. Ag(I)-Catalyzed Aminofluorination of Alkynes: Efficient Synthesis of 4-Fluoroisoquinolines and 4‑Fluoropyrrolo[α]isoquinolines Tao Xu, and Guosheng Liu* Organic Letters 2012, 14, 5416-5419. Silver-Catalyzed Fluorination Reactions Tao Xu, and Guosheng Liu* Synlett 2012, 23, 955-958. Silver-Catalyzed Intramolecular Aminofluorination of Activated Allenes Tao Xu, Xin Mu, Haihui Peng, and Guosheng Liu* Angewandte Chemie International Edition 2011, 50, 8176-8179. Palladium-Catalyzed Intramolecular Aminofluorination of Styrenes Tao Xu, Shuifa Qiu, and Guosheng Liu* Chinese Journal of Chemistry 2011, 29, 2785-2790. Palladium-catalyzed inter- and intramolecular hydroamination of styrenes coupled with alcohol oxidation using N-fluorobenzenesulfonimide as the oxidant Tao Xu, Shifa Qiu, and Guosheng Liu* Journal of Organometallic Chemistry 2011, 696, 46-49. Palladium-Catalyzed Intermolecular Aminofluorination of Styrenes Shifa Qiu, Tao Xu, Juan Zhou, Yinlong Guo, and Guosheng Liu* Journal of the American Chemical Society 2010, 132, 2856-2857.