教育背景与工作经历 本科 南开大学 化学学院 2006-2010 本科 天津大学 化工学院 2006-2010 博士 纽约州立大学布法罗分校 化学与生物工程 2011-2016 博士后 加州大学伯克利分校 生物工程 2016-2018 教授 天津大学 化工学院、生物化工系 2018.11-now

本实验室主要从事生物医学工程、纳米医学研究工作， 研究方向包括： (a)生物材料：为生物医学应用设计新型纳米药物; (b) 分子成像：开发新型造影剂，在分子水平上用于成像肠道、肿瘤等成像;c)药物递送：设计新型用于药物输送的纳米生物技术，解决相应的的临床问题

Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang*.Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy. Journal of the American Chemical Society, 2025 Xingyue Yang*, Ren Fang, Xiaotian Li, Weihao Kong, Yubao Jin, Ruohan Jiao, Zhenggong Liu, Meiqi Zhang, Qixian Peng, Yumiao Zhang*, Ningning Song*.Engineered Nanovesicles for the Precise and Noninvasive Treatment of Deep Osteomyelitis Caused by MRSA Infection with Enhanced Immune Response. ACS Applied Materials & Interface, 2025, 17 (8), 11795-11810 Jingyu Zhang, Ren Fang, Ningning Song, Yubao Jin, Meiqi Zhang, Jun Wang, Qixian Peng, He Ren*, Yumiao Zhang*, Xingyue Yang*.Multifunctional Liposomes with Enhanced Stability for Imaging-Guided Cancer Chemodynamic and Photothermal Therapy. ACS Biomaterials Science & Engineering, 2025 Jiexin Li#, Ruiqi Yang#, Yihang Yuan, He Ren, Chao Fang, Jonathan F Lovell, Yumiao Zhang*.An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound-Responsive Bacteria for Colon Cancer Immunotherapy. Advanced Functional Materials, 2024, 202414994 Zhen Jiang, Jiexin Li, Gengqi Liu, Qian Qiu, Jingyu Zhang, Minchao Hao, He Ren*, Yumiao Zhang*.A pH-Sensitive Glucose Oxidase and Hemin Coordination Micelle for Multi-Enzyme Cascade and Amplified Cancer Chemodynamic Therapy. Small, 2024, 202407674 Jiexin Li, Ruiqi Yang, Fuqiang Dong, Qian Qiu, Zhen Jiang, Chen Zhang, Gengqi Liu, Jonathan F. Lovell, Yumiao Zhang*.Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions. ACS Nano, 2024 18 (33), 21855-21872 Zixuan Wang#, Jiaxing Zhang#, Yuefei Wang*, Jialin Zhou, Xinhao Jiao, Mingshan Han, Xuelin Zhang, Hailiang Hu, Rongxin Su, Yumiao Zhang, Wei Qi Overcoming Endosomal Escape Barriers in Gene Drug Delivery Using De Novo Designed pH-Responsive Peptides. ACS Nano, 2024, 18, 10324-10340 Qian Qiu#, Jiexin Li#, He Ren, Jingyu Zhang, Gengqi Liu, Boyang Sun, Chen Zhang, Yumiao Zhang*.Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy. Small, 2024, 2402308 He Ren#, Zewen Wu#, Jingxuan Li, Nan Zhang, Coo Yee Nah, Jiexin Li, Jingyu Zhang, Jonathan F. Lovell, Liyun Zhang*, Yumiao Zhang*.A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice. BMEMat, 2024, e12104, He Ren#, Minchao Hao#, Gengqi Liu, Jiexin Li, Zhen Jiang, Wenlu Meng, Yumiao Zhang*.Oxygen Self-Supplied Perfluorocarbon-Modified Micelles for Enhanced Cancer Photodynamic Therapy and Ferroptosis. ACS Applied Bio Materials, 2024 7(5), 3306-3315 Jingyu Zhang, Jonathan F Lovell, Jiafu Shi*, Yumiao Zhang*.Nanomaterials for co-immobilization of multiple enzymes. BMEMat, 2024, e12080 Gengqi Liu, Jiexin Li, Xiaojie Wang, He Ren, Yumiao Zhang*.An Activatable Dual Polymer Nanosystem for Photoimmunotherapy And Metabolic Modulation of Deep-Seated Tumors. Advanced Healthcare Materials, 2024, 202303305 Jiexin Li, Qian Qiu, He Ren, Jingyu Zhang, Chen Zhang, Gengqi Liu, Boyang Sun, Bin Zheng, Jonathan F Lovell, Yumiao Zhang*.A metalloprotein nanoparticle scaffold co-delivers antigens and adjuvants with metal-enhanced STING activation for vaccination preventing viral infections. Nano Today, 2024, 10215 He Ren#, Jiexin Li# , Jonathan F. Lovell*, Yumiao Zhang*.Organic coordination nanoparticles for phototheranostics. Coordination Chemistry Reviews, 2024, 503, 215634 Jingang Liu, He Ren, Chen Zhang, Jiexin Li, Qian Qiu, Nan Zhang, Ning Jiang,Jonathan F. Lovell, and Yumiao Zhang*.Orally-delivered, Cytokine-engineered Extracellular Vesicles for Targeted Treatment of Inflammatory Bowel Disease. Small, 2023, 2304023 Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng-Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang*, Kateřina Vávrová*, Jonathan F Lovell*, Yumiao Zhang*.Topical Drug Delivery of Concentrated Cabazitaxel in an α-Tocopherol and DMSO Solution. Advanced Science, 2023, Aug 9:e2302658 He Ren, Jiexin Li, Jingyu Zhang, Jingang Liu, Xingyue Yang, Nan Zhang, Qian Qiu, Dan Li, Yue Yu, Xiaofeng Liu, Jonathan F. Lovell, Yumiao Zhang*.Anti-tumor immunity induced by a ternary membrane system derived from cancer cells, dendritic cells and bacteria. Small, 2023, 2002756 Boyang Sun#, Jingang Liu#, Silu Li, Jonathan F. Lovell* ,and Yumiao Zhang*.Imaging of Gastrointestinal Tract Ailments. Journal of Imaging, 2023, 9, 115 Chen Zhang, Xiaojie Wang, Gengqi Liu, He Ren, Zhen Jiang, Jingang Liu, Jonathan F. Lovell, Yumiao Zhang*.Metal Coordination Micelles for Anti-cancer Treatment by Gene-editing and Phototherapy. Journal of Controlled Release, 2023, 356, 210-221 Chen Zhang, Xiaojie Wang, Gengqi Liu, He Ren, Jingang Liu, Zhen Jiang, Yumiao Zhang*.CRISPR/Cas9 and Chlorophyll Coordination Micelles for Cancer Treatment by Genome Editing and Photodynamic Therapy. Small, 2023, 19, 2206981 Boyang Sun, Shuai Shao*, Sanjana Ghosh, Jiexin Li, Xiaojie Wang, Changning Li, Breandan Quinn, Paschalis Alexandridis, Jonathan F. Lovell*, Yumiao Zhang*.Facile Preparation of Cabazitaxel-Loaded Nanoparticles Directly Lyophilized from Dioxane. Science China Materials, 2023, 66(6): 2513-2522 Xingyue Yang, He Ren, Jiexin Li, Boyang Sun, Di Lu, Shuying Li, Yumiao Zhang*.Multifunctional ZnFeO4-Based Antibiotic-Crosslinked Nanoplatform for Magnetically-Targeted Treatment of Microbial Biofilms. ACS Applied Nano Materials, 2023, 6, 2141-2150 Zhen Jiang#, Yuanmeng Ding#, Jonathan F. Lovell, Yumiao Zhang*.Design and application of organic contrast agents for molecular imaging in the second near infrared (NIR-II) window. Photoacoustics, 2022, https://doi.org/10.1016/j.pacs.2022.100426 Jiexin Li, He Ren, Qian Qiu, Xingyue Yang, Jingyu Zhang, Chen Zhang, Boyang Sun, Jonathan F. Lovell, Yumiao Zhang*.Manganese coordination micelles that activate stimulator of interferon genes and capture in-situ tumor antigens for cancer metalloimmunotherapy. ACS Nano, 2022, 16, 10, 16909-16923 Qian Qiu, Di Lu, Gengqi Liu, Xingyue Yang, Jiexin Li, He Ren, Jingang Liu, Boyang Sun, Yumiao Zhang*.Colistin Crosslinked gemcitabine micelles to eliminate tumor drug resistance caused by intratumoral microorganisms. Bioconjugate Chemistry, 2022, 33, 10, 1944-1952 Boyang Sun, Jonathan F. Lovell, Yumiao Zhang*.Current development of cabazitaxel drug delivery systems. WIREs: Nanomedicine and Nanobiotechnology, 2022, http://doi.org/10.1002/wnan.1854 Boyang Sun, Sanjana Ghosh, Xuedan He, Wei-Chiao Huang, Breandan Quinn, Meiling Tian, Dushyant Jahagirdar, Moustafa T. Mabrouk, Joaquin Ortega, Yumiao Zhang*, Shuai Shao*, Jonathan F. Lovell*.Anti-cancer liposmal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel. Nano Research, 2022, 15, 4302-4309 Gengqi Liu, Di Lu, Shiyu Zhu, Minchao Hao, Xingyue Yang, Xiaojian Wang, Yumiao Zhang*.A new self-immolative colistin prodrug with dual targeting functionalities and reduced toxicity for the treatment of intracellular bacterial infections. Journal of Biomedical Materials Research A, 2022, 110, 1590-1598 Chen Zhang, He Ren, Gengqi Liu, Jiexin Li, Xiaojie Wang, Yumiao Zhang*.Effective Genome Editing Using CRISPR-Cas9 Nanoflowers. Advanced Healthcare Materials, 2022, 11, 10, 2102365 He Ren, Jiexin Li, Gengqi Liu, Yaping Sun, Xingyue Yang, Zhen Jiang, Jingyu Zhang, Jonathan F Lovell, Yumiao Zhang*.Anti-cancer vaccination with immunogenic micelles that capture and release pristine CD8+ T-Cell epitopes and adjuvants. ACS Applied Materials & Interfaces, 2022, 14, 2, 2510-2521 Xingyue Yang, Qian Qiu, Gengqi Liu, He Ren, Xiaojie Wang, Jonathan F. Lovell, Yumiao Zhang*.Traceless antibiotic-crosslinked micelles for rapid clearance of intracellular bacteria. Journal of Controlled Release, 2022, 341, 329-340 Jiexin Li, He Ren, Yumiao Zhang*.Metal-based nano-vaccines for cancer immunotherapy. Coordination Chemistry Reviews, 2022, 455, 214345 Yuanmeng Ding#, Byullee Park#, Jiamin Ye#, Xiaojie Wang, Gengqi Liu, Xingyue Yang, Zhen Jiang, Moongyu Han, Yong Fan, Jibin Song*, Chulhong Kim*, Yumiao Zhang*.Surfactant-stripped semiconducting polymer micelles for tumor theranostics and deep tissue imaging in the NIR-II window. Small, 2022, 18, 2104132 Jiexin Li, He Ren, Yaping Sun, Gengqi Liu, Xingyue Yang, Qian Qiu, Yuanmeng Ding, Jonathan F. Lovell, Yumiao Zhang*.Magnetic metal micelles for enhanced delivery of self-immolating CD8+ T-cell epitopes for cancer immunotherapy. Chemistry of Materials, 2021, 33, 24, 9780-9794 Zhen Jiang, Boyang Sun, Yueqi Wang, Heqi Gao, He Ren, Hao Zhang, Tong Lu, Xiangkui Ren, Wei Wei, Xiaoli Wang, Lei Zhang, Jiao Li, Dan Ding, Jonathan F. Lovell, Yumiao Zhang*.Surfactant-stripped Micelles with Aggregation-induced Enhanced Emission for Bimodal Gut Imaging in vivo and Microbiota Tagging ex vivo. Advanced Healthcare Materials, 2021, 10, 2100356 Gengqi Liu, Zhen Jiang, Jonathan F. Lovell, Lei Zhang, Yumiao Zhang*.Design of a Thiol-Responsive, Traceless Prodrug with Rapid Self-Immolation for Cancer Chemotherapy. ACS Applied Bio Materials, 2021, 4, 6, 4982-4989. Xingyue Yang, He Ren, Hong Zhang, Gengqi Liu, Zhen Jiang, Qian Qiu, Cui Yu, Niren Murthy, Kun Zhao*, Jonathan F Lovell*, Yumiao Zhang*.Antibiotic-Crosslinked Micelles with Reduced Toxicity for Multidrug Resistant Bacterial Sepsis Treatment. ACS Applied Materials & Interfaces, 2021, 13, 8, 9630-9642. Gengqi Liu, Jonathan F. Lovell, Lei Zhang*, Yumiao Zhang*.Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment. International Journal of Molecular Science, 2020, 21 (17), 6380 Maomao He, Jie Li, Hesong Han, Clarissa Araujo Borges, Gabriel Neiman, Joachim Justad Røise, Piotr Hadaczek, Rima Mendonsa, Victoria R. Holm, Ross C. Wilson, Krystof Bankiewicz, Yumiao Zhang, Corinne M. Sadlowski, Kevin Healy, Lee W. Riley and Niren Murthy*.A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction. Chemical Science, 2020, 11, 8973-8980. Boyang Sun, Huang Jing, Moustafa T. Mabrouk, Yumiao Zhang, Honglin Jin*, Jonathan F. Lovell*.A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology, 2020, 25 (10) 1281-1288.