Education Experience： 1994 Ph. D. Nagoya University, JP 1994-1999 Postdoctoral Stanford University, USA Professional Experience： 1994-2001 Research Scientist Tokyo, JAPAN 1999-2000 Postdoctoral fellow Stanford University, California, USA 2001-2009 Senior Research Scientist XenoPort, Inc. California, USA 2009-今 Professor Tianjin University, Tianjin, CHINA 2010-今 Director Tianjin Key Laboratory

The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

Synthesis and Biological Profiling of Novel Strigolactone Derivatives for Arabidopsis Growth and Development Journal of Agricultural and Food Chemistry 2023-08-30 | Journal article DOI: 10.1021/acs.jafc.3c02135 CONTRIBUTORS: Zhaoyong Kang; Yujie Yan; Ruirui Lu; Xiaoqi Dong; Jun Xu; Dong Zheng; Suhua Li; Qingzhi Gao; Shengnan Liu Sunitinib-based Proteolysis Targeting Chimeras (PROTACs) reduced the protein levels of FLT-3 and c-KIT in leukemia cell lines Zhai Jiadai,Li Chuang,Sun Bingxia,Wang Sinan,Cui Yuting,Gao Qingzhi,Sang Feng Page:129041 ISSN:0960-894X 2022 Container-title:Bioorganic & Medicinal Chemistry Letters Proteolysis Targeting Chimeras (PROTACs) Based on Promiscuous Kinase Inhibitor Synergistically Induce Cancer Cell Apoptosis Through Multiple Mechanisms ChemistrySelect 2022-10-26 | Journal article DOI: 10.1002/slct.202203463 CONTRIBUTORS: Jiadai Zhai; Chuang Li; Sinan Wang; Bingxia Sun; Yuting Cui; Qingzhi Gao; Feng Sang An Unrevealed Molecular Function of Corannulene Buckybowl Glycoconjugates in Selective Tumor Annihilation by Targeting the Cancer-Specific Warburg Effect Shengnan Liu, Ziru Sun, Min Liang, Weijie Song, Ru Zhang, Yunli Shi, Yujun Cui,* and Qingzhi Gao* Page:2105315 ISSN:2198-3844 2021 Container-title:Advanced Science DOI: 10.1002/advs.202105315 Progress on COVID-19 chemotherapeutics Zhang Ru,Sun Ziru,Liu Shengnan,Gao Qingzhi ISSN:0023-074X Container-title:Chinese Science Bulletin 2021 抗肿瘤缺氧诱导因子-1的小分子抑制剂 Development of Hypoxia Inducible Factor-1 Small Molecule Inhibitors as Antitumor Agents 王欣瑜, 赵富平, 张儒, 孙子茹, 刘胜男, 高清志 化学进展2021, Vol. 33Issue (12): 2259-2269DOI: 10.7536/PC201141 Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery Chemical Communications 2021 | Journal article DOI: 10.1039/D1CC04169J CONTRIBUTORS: Yang Li; Shengnan Liu; Min Liang; Yujun Cui; Hongxia Zhao; Qingzhi Gao A GLUT1 inhibitor-based fluorogenic probe for Warburg effect-targeted drug screening and diagnostic imaging of hyperglycolytic cancers Analytica Chimica Acta 2021-07 | Journal article DOI: 10.1016/j.aca.2021.338593 CONTRIBUTORS: Shunjie Zhang; Xinyu Wang; Ru Zhang; Yujun Cui; Heming Zhang; Weijie Song; Xiaohan Hou; Shibo Fu; Qingzhi Gao; Shengnan Liu 小分子荧光探针在绿色农药开发中的应用 Application of Small-Molecule Fluorescent Probes in the Development of Green Pesticides 侯晓涵, 刘胜男, 高清志 化学进展2021, Vol. 33Issue (6): 1035-1043DOI: 10.7536/PC200659 A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging Liu Shengnan,Song Weijie,Cui Yujun,Sun Ziru,Huang Zhenhua,Gao Qingzhi ISSN:1359-7345 Container-title:Chemical Communications 2021