教育背景及工作经历 2020-至今：深圳湾实验室，坪山生物医药研发转化中心，研究员，主任助理兼化学研究部部长 2019-至今：深圳湾实验室，北普联合研究中心，研究员，主任助理 2017-2019：北京大学化学生物学与生物技术学院，副研究员；深圳市药物筛选和临床前药效评价公共服务平台副主任 2015-2017：北京大学生命科学学院与深圳研究生院，联培博士后 2010-2015：北京大学化学生物学与生物技术学院，有机化学，博士 2006-2010：中山大学化学与化学工程学院，应用化学，学士。 奖项及荣誉 2018 深圳市自然科学奖一等奖 2017 深圳市高层次人才 2017 中国博后基金特别资助 2015 北京大学优秀毕业生

新颖合成方法学及协同催化机制研究：围绕手性化合物的高效构建，探索有机小分子催化（Organocatalysis）的成键新模式及仿生催化新机制，研究侧重于氮杂环卡宾（N-Heterocyclic carbene）以及有机小分子光敏剂（Photosensitizer）两类体系，以催化剂骨架新设计、催化新机制探索，实现挑战性成键，特别是不对称成键的反应历程。借助过渡金属催化（Transition Metal Catalysis），实现基于惰性键活化的远程不对称官能团化，侧重于新颖氮杂环卡宾配体设计及应用。依托于酶定向进化技术，基于酶催化（Enzymatic Catalysis）突破化学成键模型中的阈值上限，侧重于探索自由基反应的不对称模板。以基础研究的创新为索引及支撑，结合药物化学方向的经验积累，结合人工智能辅助药物设计方案，有的放矢对潜药分子骨架进行特异性修饰及成库建设，藉由与各学科的交叉融合，联动生物医药创制的产学研合作链条。

JACS-Csp3-Csp3 Bond Cleavage in Aromatic Hydrocarbons Ke Liao, Cho Ying Chan, Siqi Liu, Xinhao Zhang, Jiean Chen* and Yong Huang*, J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c02745. Nat Commun-Hierarchical graph learning for protein–protein interaction Gao, Z., Jiang, C., Zhang, J. et al. Hierarchical graph learning for protein–protein interaction. Nat. Commun. 14, 1093 (2023). Synlett-Addition of Alcohols onto Heteroarenium Salts Baoli Chen§, En Li§, Feifei Song, Nicolas Guimond, Jiean Chen* and Yong Huang*, Synlett, 2023, DOI: 10.1055/a-2005-5372. CS-Thiol-sulfoxonium Ylide Photo-click Reaction Chuan Wan,† Zhanfeng Hou,† Dongyan Yang,† Ziyuan Zhou, Hongkun Xu, Yuena Wang, Chuan Dai, Mingchan Liang, Jun Meng, Jiean Chen, Feng Yin,* Rui Wang* and Zigang Li*, Chem. Sci., 2022, DOI: 10.1039/D2SC05650J. Angew-Cross-Coupling of Allyl Halides and Arylboronic Acids Jingwei Xu, Zhiqi He, Jiwei Zhang, Jiean Chen* and Yong Huang*, Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202211408 CC-β-Disubstituted Enals with Benzoyl Cyanides Wangsheng Liu,† Linrui Zhang,† Xiaoyun Liao, Jiean Chen* and Yong Huang*, Chem. Commun, 2022, DOI: 10.1039/D2CC04025E. CS-Histidine-Specific Bioconjugation Chuan Wan, Yuena Wang, Chenshan Lian, Qi Chang, Yuhao An, Jiean Chen, Jinming Sun, Zhanfeng Hou, Dongyan Yang, Xiaochun Guo, Feng Yin,* Rui Wang* and Zigang Li*, Chem. Sci., 2022, DOI: 10.1039/D2SC02353A. CC-Enantioselective Synthesis of Acyclic Monohydrosilanes Delong Mu, Shuqiong Pan, Xiaoyu Wang, Xiaoyun Liao, Yong Huang* and Jiean Chen*, Chem. Commun., 2022, 58, DOI: 10.1039/D2CC02307E Angew-Enantioselective Seleno-Michael Addition Reactions En Li, Jiean Chen* and Yong Huang*, Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202202040. CRPS-Bulky and Inert Csp3–Csp3 Bonds Ke Liao, Fengjin Wu, Jiean Chen* and Yong Huang*, Cell Rep. Phy. Sci., 2022, 3, 100763. ASC-Aliphatic Aldehydes and Sulfonium Salts Baoli Chen, Li Li, Jiean Chen* and Yong Huang*, Adv. Synth. Catal., 2022, 364, 30-34. OL-1,4-Alkylcylation of 1,3-Enynes Yuxing Cai, Jiean Chen* and Yong Huang*, Org. Lett., 2021, 23, 9251-9255. ACS Catal-NHC-Catalyzed Four-Component Reaction Zhen Li, Meirong Huang, Xinhao Zhang, Jiean Chen* and Yong Huang*, ACS catal., 2021, 11, 10123-10130. CRPS-Synthesis of α-Chiral Phosphine Sulfides En Li, Qian Wang, Yuxing Cai, Jiean Chen* and Yong Huang*, Cell Rep. Phy. Sci., 2021, 2, 100490. ACS Catal-A Bifunctional N‑Heterocyclic Carbene Fangfang Guo, Jiean Chen* and Yong Huang*, ACS catal., 2021, 11, 6316-6324. CC-α-Fluorination/isomerization Cascade Xinhang Jiang, En Li, Jiean Chen* and Yong Huang*, Chem. Commun., 2021, 57, 729-732. Angew-[2,3]-Sigmatropic Rearrangement Li Li, Baoli Chen, Jiean Chen* and Yong Huang*, Angew. Chem. Int. Ed., 2020, 59, 20904-20908. iScience-Direct Synthesis of Bicyclic Acetals Fengjin Wu, Leifeng Wang, Ying Ji, Ge Zou, Hong Shen, David A. Nicewicz*, Jiean Chen* and Yong Huang*, iScience, 2020, 23, 10139. ASC-C-O Bond Coupling of Carboxylic Acids and Aryl Iodides Li Li, Feifei Song, Xiumei Zhong, Yun-Dong Wu, Xinhao Zhang*, Jiean Chen* and Yong Huang*, Adv. Synth. Catal., 2020, 362, 126-132. Synlett-Alcohol-Directed ortho-C–H Alkenylation Li Li, Qinglan Liu, Jiean Chen* and Yong Huang*, Synlett, 2019, 30, 1366-1370. Angew-Enantio- and Diastereoselective Hydrofluorination of Enals Leming Wang, Xinhang Jiang, Jiean Chen* and Yong Huang*, Angew. Chem. Int. Ed., 2019, 58, 7410-7414. N‐Heterocyclic Carbenes as Brønsted Base Catalysts Jiean Chen, Yong Huang. Book Author(s): Akkattu T. Biju. DOI :10.1002/9783527809042.ch9 APCS-Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes Wang Zhen, Li En, He Zhiqi, Chen Jiean* and Huang Yong*, Acta Phys. -Chim. Sin., 2019, 35, 906-912. JMC-Hexacyclic Camptothecin Derivatives Peichen Pan, Jiean Chen, et. al. Yong Huang* and Tingjun Hou*, J. Med. Chem., 2018, 61, 8613-8624. CEJ-Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes Qian Wang, Jiean Chen* and Yong Huang*, Chem. Eur. J., 2018, 24, 12806-12810. Angew-Enantioselective Hydroamidation of Enals Pengfei Yuan, Jiean Chen*, Jing Zhao* and Yong Huang*, Angew. Chem. Int. Ed., 2018, 57, 8503-8507. CC-Chiral Proton Shuttle Linrui Zhang, Pengfei Yuan, Jiean Chen* and Yong Huang*, Chem. Commun., 2018, 54, 1473-1476. ACS-Switching Reaction Pathways Leming Wang, Qian Wang, Jiean Chen* and Yong Huang*, Acta Chim. Sinica, 2018, 76, 850-856. Angew-Polysubstituted Aldehydes Fengjin Wu+, Leifeng Wang+, Jiean Chen*, David A. Nicewicz* and Yong Huang*, Angew. Chem. Int. Ed. 2018, 57, 2174-2178. ACS Cent Sci-Anaplastic Lymphoma Kinase Inhibitors Peichen Pan, Huidong Yu, Qinglan Liu, Xiaotian Kong, Hu Chen, Jiean Chen, et al. Yong Huang* and Tingjun Hou*, ACS Cent. Sci., 2017, 3, 11, 1208-1220. ASC-Construction of Pyridazine Analogues Chao Yang, Feifei Song, Jiean Chen* and Yong Huang*, Adv. Synth. Catal., 2017, 359, 3496-3502. JACS-Enantioselective β‑Protonation of Enals via a Shuttling Strategy Jiean Chen§, Pengfei Yuan§, Leming Wang and Yong Huang*, J. Am. Chem. Soc., 2017, 139, 7045-7051. Angew-Visible Light Mediated [4+2] Cycloaddition Leifeng Wang, Fengjin Wu, Jiean Chen, David A. Nicewicz* and Yong Huang*, Angew. Chem. Int. Ed. 2017, 56, 6896-6900. Synlett-Synthesis of Optically Active Oxazolines Fei Wang, Jiean Chen* and Yong Huang*, Synlett, 2017, 28, 1300-1304. SCC-New Frontiers of N-heterocyclic Carbene Catalysis Jiean Chen and Yong Huang*, Sci. China Chem., 2016, 59, 251-254. Synlett-Asymmetric Sulfa-Michael Addition Pengfei Yuan, Sixuan Meng, Jiean Chen* and Yong Huang*, Synlett, 2016, 27, 1068-1072 Angew-Enantioselective Aza-Michael Reaction Leming Wang+, Jiean Chen+ and Yong Huang*, Angew. Chem. Int. Ed., 2015, 54, 15414-15418. CS-Enantioselective Sulfa-Michael Addition Jiean Chen,‡ Sixuan Meng,‡ Leming Wang, Hongmei Tang and Yong Huang*, Chem. Sci., 2015, 6, 4184-4189. N Commun-N-heterocyclic Carbenes as Non-covalent Chiral Templates Jiean Chen and Yong Huang*, Nat. Commun., 2015, 5, 3437. CC-Enantioselective Synthesis of 1,2,4-Triazolines Qian Shao, Jiean Chen, Meihua Tu, David W. Piotrowskic and Yong Huang*, Chem. Commun., 2013, 49, 11098-11100. Angew-Versatile and Removable Triazene Directing Group Chengming Wang, Hu Chen, Zhaofeng Wang, Jiean Chen and Yong Huang*, Angew. Chem. Int. Ed., 2012, 51, 7242-7245.