张晓书，女，博士，副教授，2014年毕业于沈阳药科大学，获博士学位，2015年留校任教，主要研究方向为功能食品的物质基础及作用机制研究等。作为课题负责人主持国家自然科学基金青年基金1项，辽宁省教育科技向目1项，沈阳药科大学中青年教师事业发展支持计划1项，辽宁省大学生创新训练项目1项。另外，作为主要完成人参与国家“十一五”重大专项1项，国家“十一五”重大专项子平台项目1项，其他省、市级科研项目4项。目前已在JournalofFunctionalFood,Phytochemistry,JournalofAgriculturalandFoodChemistry等期刊发表论文20余篇。

研究方向一：保健食品及功能性食品的物质基础研究

研究方向二：具有抗乳腺癌的天然功能因子的发现与制备

研究方向三：抗乳腺癌活性成分的发现及作用机制研究

1.JiayinYue,YuanyuanSun,JingXu,JiaqingCao,GangChen,HuixingZhang,XiaoshuZhang*,YuqingZhao*.CucurbitanetriterpenoidsfromthefruitofMomordicacharantiaL.andtheiranti-hepaticfibrosisandanti-hepatomaactivities.Phytochemistry.157(2019)21–27.（IF3.2）

2.YumengZhang,WeihuiYuan,XudeWang,HongyuZhang,YuanyuanSun,XiaoshuZhang*andYuqingZhao*.Synthesis,characterizationandcytotoxicactivityevaluationofginsengdioloxidationandnitrogenhybridderivatives.MedChemComm.DOI:10.1039/c8md00387d.IF2.342

3.JingXu,XudeWang,GuangyueSu,YuanyuanSun,JiaqingCao,XiaoshuZhang*,YuqingZhao*.Theantioxidantandanti-hepaticfibrosisactivitiesofacorns(Quercusliaotungensis)andtheirnaturalgalloyltriterpenes.JournalofFunctionalFoods46(2018)567–578.（IF3.47）

4.XiaoshuZhang,GuohuiShi,MingbingLiu,RongChen,XiaojunWu,YuqingZhao*.Fournewdammarane-typetriterpenesderivativesfromhydrolyzateoftotalGynostemmapentaphyllumsaponinsandtheirbioactivities.NaturalProductResearch.2018.1-7.(IF1.8)

5.JingXu,JiaqingCao,JiayinYue,XiaoshuZhang*,YuqingZhao*.NewtriterpenoidsfromacornsofQuercusliaotungensisandtheirinhibitoryactivityagainstα-glucosidase,α-amylaseandprotein-tyrosinephosphatase.JournalofFunctionalFoods.2018,41:232-239.(IF3.47)

6.JingXu,JiaqingCao,JiayinYue,XiaoshuZhang*,YuqingZhao*.NewtriterpenoidsfromacornsofQuercusliaotungensisandtheirinhibitoryactivityagainstα-glucosidase,α-amylaseandprotein-tyrosinephosphatase.JournalofFunctionalFoods.2018,41:232-239.(IF3.47)

7.XiaoshuZhang,GuohuiShi,MingbingLiu,RongChen,XiaojunWu,YuqingZhao*.Fournewdammarane-typetriterpenesderivativesfromhydrolyzateoftotalGynostemmapentaphyllumsaponinsandtheirbioactivities.NaturalProductResearch.2018.1-7.(IF1.92)

8.XiaoshuZhang,GuohuiShi,MingbingLiu,RongChen,XiaojunWu,YuqingZhao*.Protectiveeffectsofdammarane-typetriterpenesfromhydrolyzateofGynostemmapentaphyllumagainstH2O2-inducedinjuryandanti-hepaticfibrosisactivities.PhytochemistryLetters.25(2018)33–36.(IF1.5)

9.LuMa,YuancaiChen,XudeWang,MingzhouXiong,YuanyuanSun,XiaoshuZhang*,YuqingZhao*.Design,characterization,andinvitroantiproliferativeefficacyofgemcitabineconjugatesbasedoncarboxymethylglucan.Bioorganic&MedicinalChemistryLetters.28(2018)2920–2924.(IF2.442)

10.JingXu,XudeWang,JiayinYue,YuanyuanSun,XiaoshuZhangandYuqingZhao*.PolyphenolsfromAcornLeaves(Quercusliaotungensis)ProtectPancreaticBetaCellsandTheirInhibitoryActivityagainsta-GlucosidaseandProteinTyrosinePhosphatase1B.Molecules.2018,23:2167.(IF3.2)