寸冬梅
教授 博导
个人简介
1999年毕业于北京医科大学,获药学专业理学学士学位,2005年获沈阳药科大学药剂学博士学位。2007至2011年在丹麦哥本哈根大学做博士后研究工作,从事小分子干扰核酸(siRNA)的纳米微粒传递系统的研究。现任沈阳药科大学药物制剂教研室教师,2009年被聘为硕士生导师。多年来一直从事递送生物大分子的新型给药系统的研究,共主持5项科研课题,其中包括国家自然基金青年项目1项(23万),省部级科研项目3项(36万)和校级科研项目一项(10 万);参与国家级科研项目4项;获辽宁省自然科学学术成果一等奖1项。
研究领域
涉及核酸、蛋白质、多肽等生物大分子的递送,聚合物微球、纳米粒的设计以及肺部吸入制剂的研究。
近期论文
Wu L,Leng D,Cun D,Foged C,Yang M.advances in combination therapy of lung cancer:rationales,delivery technologies and dosage regimens.J Control Release.2017,online. Sun L,Liu Z,Wang L,Cun D,Tong HHY,Yan R,Chen X,Wang R,Zheng Y.Ehanced topical penetration,system exposure and anti-psoriasis activity of two particele-sized,curcumin-loaded PLGA nanoparticles in hydrogel.J Control Release.2017,254:44-54 Ying Li,Meihua Han,Tingting Liu,Dongmei Cun,Liang Fang,Mingshi Yang.Inhaled hyaluronic acid microparticles extended pulmonary retention and suppressed systemic exposure of a short-acting bronchodilator.Carbohydrate Polymers.2017. Cun D, Wang F, Yang M. Formulation strategies and particle engineering technologies for pulmonary delivery of biopharmaceuticals, Curr Pharm Des. 2015, 21(19):2599-610.(第一作者,IF 3.504) Colombo S,Cun D, Remaut K, Bunker M, Zhang J, Martin-Bertelsen B, Yaghmur A, Braeckmans K, Nielsen HM, Foged C.Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles.J Control Release. 2015, 201:22-31. (共同第一作者,通讯作者,IF 8.097) W Guo, P Quan, L Fang,D Cun, M Yang. Sustained release donepezil loaded PLGA microspheres for injection: Preparation, in vitro and in vivo study, Asian J Pharm Sci. 2015,10, 405–414. (通讯作者) Cun D, Jensen DMK, Maltesen MJ, Bunker M, Whitside P, Scurr D, Foged C, Nielsen HM. High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: Quality by design optimization and characterization. Eur J Pharm Biopharm, 2011, 77: 26-35.(第一作者,IF 4.394 Jensen DK,Cun D, Maltesen MJ, Frøkjær S, Nielsen HM; Foged C. Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation. J Control Release.2010, 142: 138-145.((共同第一作者,IF 8.097) Cun D, Foged C,Yang M, Frøkjær S, Nielsen HM. Preparation and characterization of poly (DL-lactide-co-glycolide) nanoparticles for siRNA delivery. Int J Pharm.2010, 390: 70-75.(第一作者,IF 4.011) CunD, CuiF, YangL, YangM,YuY,YangR. Characterization and Release Mechanism of Melittin Entrapped Poly (lactic acid-co-glycolic acid) Microspheres. Journal of Drug Delivery Science and Technology, 2008, 18(4): 267-272.(第一作者,IF 0.655) CunD,JensenLB, NielsenHM, MoeinM, FrokjaerS, FogedC. Polymeric Nanocarriers for siRNA Delivery: Challenges and Future Prospects. Journal of Biomedicince and Nanotechnology, 2008, 4: 1-18.(第一作者,IF 5.338) CuiF,CunD, Tao, A, Yang, M, Shi, K, Zhao, M. Preparation and evaluation of melittin loaded poly (D, L-lactic acid) or poly D, L-lactic-co-glycolic acid) microspheres made by the double emulsion method. Journal of Controlled Release, 2005, 107(2): 310-319. (IF 8.097)