张元兴
教授
所属大学: 生物反应器工程国家重点实验室
所属学院: 未知
个人简介
1982年1月毕业于华东化工学院化学工程系,获学士学位。1984年7月毕业于华东化工学院生物化工系,获硕士学位,1995年9月评为华东理工大学教授。1997年担任博士生导师。1998年享受国务院政府特殊津贴
研究领域
1. 海洋生物技术。研究海洋病原微生物的特性,掌握其致病规律,在分子水平上阐明细胞通讯相关的条件致病现象,确定致病相关功能基因,从基因水平上进行改造,开发减毒活疫苗和多效价疫苗 2. 微生物工程。研究甲醇酵母基因诱导水平的精密控制网络,构建新的蛋白表达体系。通过基因重组微生物的高密度培养和基因调控,高表达重组产物,生产药用蛋白。在海洋微生物培养中,阐明丝状菌次级代谢调控的规律,调控菌丝形态,高效合成活性化合物
近期论文
1. Tao Jiang, Mengmeng Huang, Hao He, Jian Lu, Xiangshan Zhou, Menghao Cai*, Yuanxing Zhang. Bioprocess exploration for thermostable α-amylase production of a deep-sea thermophile Geobacillus sp. in high temperature bioreactor. Preparative Biochemistry & Biotechnology 2015, accepted. 2. 董浩苏, 吴海珍*, 张元兴. 壳聚糖微纳米粒作为鱼类疫苗佐剂的应用研究. 华东理工大学学报, 接受. 3. 胡伟, 李佳欣, 李晓霞, 周祥山*, 蔡孟浩*, 张元兴. 流体剪切敏感型海洋灰绿曲霉AgugtA和AgugeA基因的克隆及功能分析. 华东理工大学学报, 接受. 4. Ni Ye, Haizhen Wu*, Qiyao Wang, Qin Liu, Jingfan Xiao, Yuanxing Zhang. Maternal transfer and protection role in zebrafish offspring following vaccination of the brood stock with a live attenuated Vibrio anguillarum vaccine. Aquaculture Research 2015, accepted. 5. Tongcheng Dai, Na Li, Lu Liu, Qin Liu*, Yuanxing Zhang. AMP-conjugated quantum dots: low immunotoxicity both in vitro and in vivo. Nanoscale Research Letters 2015, accepted. 6. Xiaolong Wang,·Menghao Cai*,·Lei Shi, Qi Wang, Jinxiang Zhu, Jinjia Wang, Mian Zhou,·Xiangshan Zhou, Yuanxing Zhang. PpNrg1 is a transcriptional repressor for glucose and glycerol repression of AOX1 promoter in methylotrophic yeast Pichia pastoris. Biotechnology Letters 2015, accepted. 7. Meixia Wang, Hao He, Ke Na, Menghao Cai*, Xiangshan Zhou, Wenjie Zhao, Yuanxing Zhang. Designing novel glucose/ornithine replenishment strategies by biosynthetic and bioprocess analysis to improve fibrinolytic FGFC1 production by the marine fungus Stachybotrys longispora. Process Biochemistry 2015, accepted. 8. Xiaohong Liu, Hua Zhang, Yuan Gao, Yang Zhang, Haizhen Wu*, Yuanxing Zhang. Efficacy of chitosan oligosaccharide as aquatic adjuvant administrated with a formalin-inactivated Vibrio anguillarum vaccine. Fish & Shellfish Immunology 2015, accepted. 9. Jiao Zhou, Hao He, Xiaolong Wang, Jian Lu, Xiangshan Zhou, Menghao Cai*, Yuanxing Zhang. Optimization of nutrients for dinactin production by a marine Streptomyces sp. from High Latitude Arctic. Biotechnology and Bioprocess Engineering 2015, 20(4): 725-732. 10. Zhongyang Sun, Binbing Shen, Haizhen Wu*, Xiangyu Zhou, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang. The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish & Shellfish Immunology 2015, 46(2): 638-647. 11. Tao Jiang, Menghao Cai*, Mengmeng Huang, Hao He, Jian Lu, Xiangshan Zhou, Yuanxing Zhang. Characterization of a thermostable raw-starch hydrolyzing ?-amylase from deep-sea thermophile Geobacillus sp. Protein Expression and Purification 2015, 114: 15-22. 12. Teng Chu, Yajun Huang, Mingyu Hou, Qiyao Wang, Jingfan Xiao, Qin Liu*, Yuanxing Zhang. In vivo programmed gene expression based on artificial quorum networks. Applied and Environmental Microbiology 2015, 81(15): 4984-4992. 13. Teng Chu, Lingyu Guan, Pengfei Shang, Qiyao Wang, Jingfan Xiao, Qin Liu*, Yuanxing Zhang. A controllable bacteria lysis system to enhance biological safety of live attenuated Vibrio anguillarum vaccine. Fish & Shellfish Immunology 2015, 45(2): 742-749. 14. Xiaohong Liu, Haizhen Wu*, Qin Liu, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang. Skin-injury zebrafish, Danio rerio, are more susceptible to Vibrio anguillarum infection. Journal of the World Aquaculture Society 2015, 46(3): 301-310. 15. Xiaohong Liu, Haizhen Wu*, Qin Liu, Qiyao Wang, Jingfan Xiao, Xinyue Chang, Yuanxing Zhang. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish & Shellfish Immunology 2015, 45(2): 342-345. 16. Hesong Liu, Yue Wang, Jingfan Xiao*, Qiyao Wang, Qin Liu, Yuanxing Zhang. An immunochromatographic test strip for rapid detection of fish pathogen Edwardsiella tarda. Bioresouces and Bioprocessing 2015, 2: 20. 17. Teng Chu, Chunshan Ni, Lingzhi Zhang, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang, Qin Liu*. A quorum sensing-based in vivo expression system and its application in multivalent bacterial vaccine. Microbial Cell Factories 2015, 14: 37. 18. Shuai Shao, Qiliang Lai, Qin Liu, Haizhen Wu, Jingfan Xiao, Zongze Shao, Qiyao Wang*, Yuanxing Zhang. Phylogenomics characterization of a highly virulent Edwardsiella strain ET080813T encoding two distinct T3SS and three T6SS gene clusters: propose a novel species as Edwardsiella anguillarum sp. nov. Systematic and Applied Microbiology 2015, 38(1): 36-47. 19. Weizheng Yang, Lixia Wang, Lingzhi Zhang, Jiangbo Qu, Qiyao Wang*, Yuanxing Zhang. An invasive and low virulent Edwardsiella tarda esrB mutant promising as live attenuated vaccine in aquaculture. Applied Microbiology and Biotechnology 2015, 99(4): 1765-1777. 20. Hua Zhang, Haizhen Wu*, Liang Gao, Ying Qiu, Jingfan Xiao, Yuanxing Zhang. Identification, expression and immunological response to bacterial challenge following vaccination of BLT1 gene from turbot, Scophthalmus maximus. Gene 2015, 557(2): 229-235.