1962年生，1984年毕业于华东化工学院生化工程专业后即留校任教，1997年获华东理工大学生化工程硕士学位，2006年获华东理工大学生物化工博士学位。现任华东理工大学生物工程学院分党委书记，国家生化工程技术研究中心（上海）副主任，上海生物制造产业技术研究院副院长，“863”生物和医药领域工业生物技术主题专家，中国微生物学会第十届理事会常务理事，生化过程模型化与控制专业委员会主任委员，中国化工学会生物化工专业委员会副主任委员

主要从事发酵过程的优化与放大研究

1. Yong Chen, Zejiang Wang, Ju Chu*, Beili Xi, Yingping Zhuang. The glucose RQ-feedback control leading to improved erythromycin production by a recombinant strain Saccharopolyspora erythraea ZL1004 and its scale-up to 372-m(3) fermenter. Bioprocess & Biosystems Engineering. 2015, 38(1):105-112, DOI: 10.1007/s00449-014-1248-8

2. Hongzhong Lu，Chao Li，Wenjun Tang，Zejian Wang，Jianye Xia，Siliang Zhang，Yingping Zhuang，Ju Chu，Henk Noorman，Dependence of fungal characteristics on seed morphology and shear stress in bioreactor. Bioprocess & Biosystems Engineering. 2015, 38(5):917-928, DOI: 10.1007/s00449-014-1337-8

3. Fei Shi, Jun Tan, Ju Chu, Yonghong Wang, Yingping Zhuang, Siliang Zhang. A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger. Journal of Microbiologcal Methods. 109:134-139, DOI: 10.1016/ j.mimet.2014.12.004

4. Guan Wang, Ju Chu, Henk Noorman, Jianye Xia, Wenjun Tang, Yingping Zhuang, Siliang Zhang. Prelude to rational scale-up of penicillin production: a scale-down study. Applied Microbiology and Biotechnolog. 2014, DOI:10.1007/s00253-013-5497-2

5. Minghui Xie, Jianye Xia*, Zhen Zhou, Ju Chu, Yingping Zhuang, Siliang Zhang, Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors. Industrial & Engineering Chemistry Research. 2014, 53(14): 5941-5953, DOI: 10.1021/ie400831s

6. Minghui Xie, Jianye Xia*, Zhen Zhou,Zhou Guozhong, Ju Chu, Yingping Zhuang, Siliang Zhang, Henk Noorman, Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions. Chemical Engineering Science. 2014, 106:144-`56. DOI: 10.1016/j.ces.2013.10.032

7. Lan Li, Zejian Wang*, Xuejun Chen, Ju Chu, Yingping Zhuang, Siliang Zhang, Optimization of polyhydroxyalkanoates fermentations with on-line capacitance measurement. Bioresource Technology. 2014, 156:216-221. DOI: 10.1016/j.biortech.2014.01.042

8. Lei Deng, Bingyang Shi, Yingping Zhuang, Ju Chu, Xiaolin Shi, Siliang Zhang, Meijin Guo*, Performance and Mechanism of Neuroleukin in the Growth and Survival of Sertoli Cell-Induced Neurons in a Coculture System. Cell Transplantation. 2014, 23(3): 381-394, DOI: 10.3727/096368913X663578

9. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang,. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on L-lactic acid production efficiency by Lactobacillus paracasei. Process Biochemistry. 2014,49(12): 2049-2054, DOI: 10.1016/j.procbio.2014.06.014

10. Yongsheng Nie, Mingzhi Huang*, Junjie Lu, Jiangchao Qian, Weilu Lin, Ju Chu, Yingping Zhuang, Siliang Zhang. Impacts of high beta-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via C-13 metabolic flux analysis. Journal of Biotechnology. 2014, 187:124-134, DOI: 10.1016/j.jbiotec.2014.07.011

11. Xiaoqing Hu, Ju Chu, Siliang Zhang, Yingping Zhuang, Xin Wu, Huaxin Chen, Zhongyuan Lv, Zhongyi Yuan. An alkaline pH control strategy for methionine adenosyltransferase production in Pichia pastoris fermentation. Biotechnology & Bioprocess Engineering. 2014, 19(5): 900-907, DOI: 10.1007/s12257-014-0046-0

12. Xiwei Tian, Yonghong Wang*, Ju Chu*, Yingping Zhuang, Siliang Zhang,. L-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination. Bioprocess & Biosystems Engineering. 2014, 37(9): 1917-1923, DOI: 10.1007/s00449-014-1166-9

13. Taicheng Zhu, Haifeng Hang, Ju Chu, Yingping Zhuang, Siliang Zhang, Meijin Guo. Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichia pastoris. Journal of Industrial Microbiology & Biotechnology. 2013, 40(2) : 183-189 DOI: 10.1007/s10295-012-1225-7

14. Ju Chu, Jiangchao Qian, Yingping Zhuang, Siliang Zhang. Progress in the research of S-adenosyl-L-methionine production. Applied Microbiology Biotechnology. 2013, 97(1):41-49 DOI: 10.1007/s00253-012-4536-8

15. Yong Chen,Mingzhi Huang,Zejian Wang,Ju Chu,Yingping Zhuang,Siliang Zhang, Controlling the feed rate of glucose and propanol for the enhancement of erythromycin production and exploration of propanol metabolism fate by quantitative metabolic flux analysis. Bioprocess and Biosystems Engineering. 2013, 36(10): 1445-1453

16. Jun Tan,Ju Chu,Yuyou Hao,Yuanxin Guo,Yingping Zhuang,Siliang Zhang, High-Throughput System for Screening of Cephalosporin C High-Yield Strain by 48-Deep-Well Microtiter Plates. Applied Biochemistry and Biotechnology. 2013, 169(5): 1683-1695

17. Chao Li, Jianye Xia*, Ju Chu, Yonghong Wang*, Yingping Zhuang,; Siliang Zhang, CFD analysis of the turbulent flow in baffled shake flasks. Biochemical Eneineering Journal. 2013, 70:140-150

18. Yong Chen, Zejian Wang, Ju Chu, Yingping Zhuang, Siliang Zhang, Yu Xiaoguan, Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate. Bioresource Technology. 2013,134:173-179. DOI: 10.1016/j.biortech.2013.02.023

19. Xiang Zou,Wanjun Li,Wei Zeng,Haifeng Hang,Ju Chu,Yingping Zhuang,Siliang Zhang, Biochemical Parameters of Saccharopolyspora Erythraea during Feeding Ammonium Sulphate in Erythromycin Biosynthesis Phase. Applied Biochemistry & Microbiology. 2013,49(2): 169-175 DOI: 10.1134/S0003683813020166

20. Xiang Zou, Wanjun Li, Wei Zeng, Hangfeng Hang, Ju Chu, Yingping Zhuang, Siliang Zhang. Biochemical Parameters of Saccharopolyspora Erythraea during Feeding Ammonium Sulphate in Erythromycin Biosynthesis Phase. Applied Biochemistry & Microbiology. 2013, 49(2):169-175. DOI: 10.1134/S0003683813020166