1988年获华东化工学院（现华东理工大学）生物化学专业理学学士学位；1991年获华东理工大学生物化工专业工学硕士学位；毕业后留校任教，期间曾在香港城市大学生物及化学系开展研究工作。现任华东理工大学生物反应器工程国家重点实验室教授，博士生导师，动物细胞与组织工程研究室副主任

一直从事动物细胞培养技术研究及其在干细胞体外培养和人体组织体外构建中的应用，研究工作聚焦于动物细胞体外培养的无血清培养基研制、基于代谢工程的动物细胞大规模无血清高密度悬浮培养技术、采用生物反应器及微载体细胞培养体系生产病毒疫苗、干细胞体外规模化扩增和定向诱导分化、工程化人体组织体外构建新技术及生物反应器研制

1、动物细胞大规模培养技术。 2、组织工程种子细胞体外扩增、干细胞定向诱导分化及功能老化规律。 3、细胞与生物材料相互作用和细胞3D培养。 4、人体组织体外构建技术及其生物反应器。

1. Xiao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan*, Yi-Tao Ding*, Lijian Hui*. Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. Cell Research. 2016; 26(2):206-216.

2. Yingdi Zhao, Ke Tan, Yan Zhou, Zhaoyang Ye*, Wen-Song Tan. A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(?-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells. Materials Science and Engineering: C. 2016; 1(59): 193-202.

3. Yaya Liu, Weiyan Zhang, Xiancun Deng, Hong Fai Poon, Xuping Liu, Wen-Song Tan, Yan Zhou, Li Fan*. Chinese hamster ovary cell performance enhanced by a rational divide-and conquer strategy for chemically defined medium development. Journal of Bioscience and Bioengineering. 2015; 120(6): 690-696.

4. Lei Xu, Zhaoyang Ye*, Yan Zhou and Wen-Song Tan. Towards engineering complex tissue/organs: a coculture perspective. Austin Journal of Biomedical Engineering. 2015; 2(1): 1028-1029.

5. Min Chen, Yi Zhang, Yan Zhou, Yan Zhang, Meidong Lang, Zhaoyang Ye*, Wensong Tan*. Pendant small functional groups on poly(?-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells. Colloids and Surfaces B Biointerfaces. 2015; 134: 322-331.

6. Feiyue Xu, Lei Xu, Qi Wang, Yan Zhou, Zhaoyang Ye*, Wen-Song Tan*. A three-dimensional dynamic coculture system enabling facile cell separation for chondrogenesis of mesenchymal stem cells. Biochemical Engineering Journal, 2015; 15(103): 68-76.

7. Houyong Luo, Maiqin Chen, Xiu Wang, Yang Mei, Zhaoyang Ye*, Yan Zhou*, Wen-Song Tan. Fabrication of centimeter-sized viable 3D tissue constructs endowed with microchannel conduits for improved tissue properties through assembling of cell-laden microbeads. Journal of Tissue Engineering and Regenerative Medicine. 2014; 8: 493-504.

8. Xiu Wang, Qingling Jiao, Songjie Zhang, Zhaoyang Ye*, Yan Zhou*, Wen-Song Tan. Perfusion culture induced template-assisted assembling of cell-laden microcarriers is a promising route for fabricating macrotissues. Biotechnology Journal. 2014; 9: 1425-1434.

9. Maiqin Chen, Min Zhou, Zhaoyang Ye*, Yan Zhou*, Wen-Song Tan*. Ectopic osteogenesis of macroscopic tissue constructs assembled from human mesenchymal stem cell-laden microcarriers through In vitro perfusion culture. PLoS ONE. 2014; 9(10): e109214.

10. Yan Zhang*, Yi Zhang, Min Chen, Yan Zhou, Meidong Lang*. Galactosylated poly(ε-caprolactone) membrane promoted liver-specific functions of HepG2 cells in vitro. Materials Science and Engineering, C. 2014; 41: 52-58.

11. Feiyue Xu, Lei Xu, Qi Wang, Zhaoyang Ye*, Yan Zhou, Wen-Song Tan*. 3D dynamic culture of rabbit articular chondrocytes encapsulated in alginate gel beads using spinner flasks for cartilage tissue regeneration. BioMed Research International. 2014; 2014: 1-10.

12. Qingchun Zhang, Houyong Luo, Yan Zhang, Yan Zhou, Zhaoyang Ye*, Wensong Tan, Meidong Lang*. Fabrication of three-dimensional poly(ε-caprolactone) scaffolds with hierarchical pore structures for tissue engineering. Materials Science and Engineering C. 2013; 33: 2094-2103.

13. Lei Xu, Qi Wang, Feiyue Xu, Zhaoyang Ye*, Yan Zhou, Wen-Song Tan*. Mesenchymal stem cells downregulate articular chondrocyte differentiation in noncontact coculture systems: implications in cartilage tissue regeneration. Stem Cells and Development. 2013; 22(11): 1657-1669.

14. Ying Ma*, Ying Zhang, Shan Zhao, Yu Wang, Siran Wang, Yan Zhou, Na Li, Hongguo Xie, Weiting Yu, Yang Liu, Wei Wang, Xiaojun Ma*. Modeling and optimization of membrane preparation conditions of the alginate-based microcapsules with response surface methodology. Journal of Biomedical Materials Research Part A. 2012; 100A: 989-998.

15. Yi Zhang, Yan Zhang*, Min Chen, Jinliang Yan, Zhaoyang Ye, Yan Zhou, Wensong Tan, Meidong Lang. Surface properties of amino-functionalized poly(ε-caprolactone) membranes and the improvement of human mesenchymal stem cell behavior. Journal of Colloid and Interface Science. 2012; 368, 64-69.

16. Fei Chen, Li Fan, Jiaqi Wang, Yan Zhou, Zhaoyang Ye, Liang Zhao*, Wensong Tan. Insight into the roles of hypoxanthine and thymidine on cultivating antibody-producing CHO cells: cell growth, antibody production and long-term stability. Applied Microbiology and Biotechnology. 2012; 93(1): 169-178.

17. Wei Wu, Zhaoyang Ye, Yan Zhou*, Wen-Song Tan. AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. The International Journal of Artificial Organs. 2011; 34(12): 1128-1136

18. Maiqin Chen, Xiu Wang, Zhaoyang Ye, Yan Zhang, Yan Zhou*, Wen-Song Tan*. A modular approach to the engineering of centimeter-sized bone tissue constructs using human amniotic mesenchymal stem cells-laden microcarriers. Biomaterials. 2011; 32(30): 7532-7542.

19. Tianci Kou, Li Fan, Zhaoyang Ye, Yan Zhou, Xuping Liu, Liang Zhao*, Wensong Tan. Process analysis of reduced specific productivity of TNFR-Fc in chinese hamster ovary cells at high cell density. Process Biochemistry. 2011; 46: 1492-1499.

20. Zhaoyang Ye*, Yan Zhou, Haibo Cai, Wensong Tan. Myocardial regeneration: Roles of stem cells and hydrogels. Advanced Drug Delivery Reviews. 2011; 63: 688-697