阳大海 照片

阳大海

副教授 硕导

所属大学: 生物反应器工程国家重点实验室

所属学院: 未知

邮箱:
dahaiyang@ecust.edu.cn

个人主页:
http://sklbe.ecust.edu.cn/Web/Show?w=146&p=106&f=830

个人简介

2018.09- 今 华东理工大学生物工程学院 副教授,硕士生导师 2015.12-2018.08 华东理工大学生物工程学院 讲师 2013.08-2015.05 美国密西根大学医学院 联培博士,合作导师:Gabriel Nunez 2010.09-2015.06 华东理工大学生物工程学院 博士,合作导师:刘琴/张元兴

研究领域

1. 细菌感染激活细胞焦亡分子机制

2. 感染性多器官损伤分子机制

3. 鱼类抗感染免疫应答分子机制

近期论文

Yang D., Zheng X., Chen S., Wang Z., Xu W., Tan J., Hou M., Wang W., Gu Z., Wang Q., Zhang R., Zhang Y., Liu Q.*, Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish, Nature Communications2018, 9: 3025. (IF=12.353, 第一作者)

Yang D., He Y., Muñoz-Planillo R., Liu Q.*, Núñez G.*. Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock. Immunity 2015, 43: 923-932.(IF=24.082, 第一作者)

Yang D.#, Liu X. #, Xu W., Gu Z., Yang C., Zhang L., Tan J., Zheng X., Wang Z., Quan S., Zhang Y., Liu Q.*. The Edwardsiella piscicidathioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection, PLoS Pathogens 2019, 15(7):e1007917. (IF=6.4, 共同一作)

Wen Y., Chen S., Jiang Z., Wang Z., Tan J., Hu T., Wang Q., Zhou X., Zhang Y., Liu Q., Yang D.*, Haemolysin promotes bacterial outer membrane vesicles-induced pyroptotic-like cell death in zebrafish, Cellular Microbiology 2019, e13010. (IF=4.41, 唯一通讯)

Wang Z., Lin L., Chen W., Zheng X., Zhang Y., Liu Q., Yang D.*, Neutrophil plays critical role during Edwardsiella piscicidaimmersion infection in zebrafish larvae. Fish and Shellfish Immunology 2019, 87: 565-572. (IF=3.185, 唯一通讯)

Xu W., Gu Z., Zhang L., Zhang Y., Liu Q., Yang D.*, Edwardsiella piscicida virulence effector trxlp promotes the NLRC4 inflammasome activation during infection, Microbial Pathogenesis 2018, 123: 496-504. (IF=2.332, 唯一通讯)

Cao H., Yang C., Quan S., Hu T., Zhang L., Zhang Y., Yang D.*, Liu Q.*, Novel T3SS effector EseK in Edwardsiella piscicida is chaperoned by EscH and EscS to express virulence, Cellular Microbiology 2018, 20 (1): e12790. (IF=4.41, 共同通讯)

Cao H., Han F., Tan J., Hou M., Zhang Y., Yang D.*, Liu Q.*, Edwardsiella piscicida T3SS effector EseK inhibits MAPKs phosphorylation and promotes bacterial colonization in zebrafish larvae, Infection and Immunity 2018, 68 (9): e00233-18. (IF=3.63, 共同通讯)

Yang D., Liu Q.*, Ni C., Li S., Wu H., Wang Q., Xiao J., Zhang Y., Gene expression profiling in live attenuated Edwardsiella tardavaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish, Developmental and Comparative Immunology 2013, 40: 132-141. (IF=3.25, 第一作者)

Yang D., Liu Q.*, Yang M, Wu H., Wang Q., Xiao J., Zhang Y.*, RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish, BMC genomics 2012, 13: 319. (IF=3.620, 第一作者)"