曾在医药企业工作多年，主要从事抗生素发酵，生物、生化药物的生产与管理，以及药物的研发工作。现为华东理工大学生物工程学院以及生物反应器工程国家重点实验室工作人员，其间于2012年8月赴美国佐治亚理工化学与生物分子工程学院进行为期一年的访问交流。主要从事生物技术药物领域的研发和相关技术研究工作，着力于生物技术的工业化应用。承担和参与了多项科技部“863”项目、国家自然科学基金项目，科研成果获得多次上海市和国家级奖励，多项科研成果实现了产业化转化。

代谢工程：微生物代谢过程分析、调控及育种。应用于基因工程蛋白药物的制备与研发以及其它生物技术药物的发酵制备过程研究。 生物催化与转化：微生物新功能酶源的筛选和性能研究;生物催化反应的工业化应用

1. Xu tao，Zhang Lujia, Su Erzheng, Cui Dongbing, Wang Xuedong, Wei Dongzhi （2010）Disparity in productive binding mode of the slow-reacting enantiomer determines the novel catalytic behavior of Candida antarctica lipase B, Journal of Molecular Catalysis B: Enzymatic 62 (2010) 288–296

2. Wang Hengwei, Cheng Hairong, Wang Fengqing, Wei Dongzhi, Wang Xuedong (2010) An improved 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction assay for evaluating the viability of Escherichia coli cells, Journal of Microbiological Methods 82:330–333

3. Zhang Jianguo, Wang Xuedong, Shen Danhong (2011) Efficient conversion from polysialogangliosides to monosialotetrahexosylganglioside using Oerskovia xanthineolytica YZ-2 2010 Bioprocess Biosyst Eng 34, (4): 493

4. Yang Chunsheng, Wang Xuedong, Wei Dongzhi (2011) A New Nitrilase-Producing Strain Named Rhodobacter sphaeroides LHS-305: Biocatalytic Characterization and Substrate Specificity Applied Biochemistry and Biotechnology 16(7): 1556-1567

5. Wang Hualei, Li Guinan, Li Mingyang, Wei Dongzhi; Wang Xuedong (2014) A novel nitrilase from Rhodobacter sphaeroides LHS-305 cloning, heterologous expression and biochemical characterization World J Microbiol Biotechnol 30(1):245-52

6. Li Mingyang, Wang Xuedong （2014） The influence of hydroxypropyl-β-cyclodextrin on the enantioselective hydrolysis of 2-amino phenylpropionitrile catalyzed by recombinant nitrilase Bioresources and Bioprocessing 1:4

7. Gao Xingqiang, Feng Jianxun, Hua Qiang, Wei Dongzhi, Wang Xuedong (2014) Investigation of factors affecting biotransformation of phytosterols to 9-hydroxyandrost-4-ene-3, 17-dione based on the HP-β-CD-resting cells reaction system Biocatalysis and Biotransformation 32: 343–347

8. Xu Xinwei, Gao Xingqiang, Feng Jianxun, Wang Xuedong, Wei Dongzhi (2015) In?uence of temperature on nucleus degradation of 4-androstene-3,17-dione in phytosterol biotransformation by Mycobacterium Letters in Applied Microbiology 61: 63—68

9. Wang Hualei, Gao Wenyuan, Sun Huihui, Chen Lifeng, Zhang Lujia, Wang Xuedong, Wei Dongzhi （2015）Protein Engineering of a Nitrilase from Burkholderia cenocepacia J2315 for Efficient and Enantioselective Production of (R)-o-Chloromandelic Acid Applied and Environmental Microbiology 81（24）：8469

10. Yao Meiling, Zhang Jianguo, Wang Xuedong (2015) High-level secretion of human bikunin from recombinant Pichia pastoris Letters in Applied Microbiology 61: 63—68

11. Gao Xingqiang, Feng Jianxun, Hua Qiang, Wang Xuedong, Wei Dongzhi (2015) Enhanced steroid metabolites production by resting cell phytosterol bioconversion Chem. Biochem. Eng. Q., 29 (4): 343