沈亚领
教授
个人简介
生物反应器工程国家重点实验室和生物工程学院教授,生物化工、生物工程与技术/发酵工程专业
博士研究生导师,微生物学专业硕士生导师
研究领域
1. 生物化工/生物工程与技术/发酵工程:药用蛋白质/多肽/小分子产业化研发、靶向递药系统;生物下游过程;生物基化学品。
2. 微生物学:微生物群体效应及功能基因;微生物代谢工程和合成生物学;发酵生理
近期论文
1. Liaoyuan Zhang, Zewang Guo, Jiebo Chen, Quanming Xu, Hui Lin, Kaihui Hu, Xiong Guan & Yaling Shen*, Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241, Sci. Rep. 6, 19257; doi: 10.1038/srep19257 (2016)
2. Jiying Fan, Liying Huang, Jing Sun, Yi Qiu, Jinsong Zhou, Yaling Shen*, Strategy for linker selection to enhance refolding and bioactivity of VAS-TRAIL fusion protein based on inclusion body conformation and activity, Journal of Biotechnology, 2015, 209 , 16–22
3. Fangmin Bai, Lu Dai, Jiying Fan, Ngoctu Truong, Ben Rao, Liaoyuan Zhang, Yaling Shen*, Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)- 2,3-butanediol production, Journal of Industrial Microbiology and Biotechnology, 2015, 42(6), 779-786
4. Quanming Xu, Linxiang Xie, Yongyu Li, Hui Lin, Shujing Sun, Xiong Guan, Kaihui Hu, Yaling Shen*, Liaoyuan Zhang*, Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin, Journal of Chemical Technology and Biotechnology, 2015,90,93–100
5. Liaoyuan Zhang, Quanming Xu, Xiaoqian Peng, Boheng Xu, Yuehao Wu, Yulong Yang, Shujing Sun, Kaihui Hu, Yaling Shen*. Cloning, expression and characterization of glycerol dehydrogenase involved in 2,3-butanediol formation in Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology, 2014,41(9),1319–1327
6. Liaoyuan Zhang*, Quanming Xu, Senran Zhan, Hui Lin, Shujing Sun, Li Sha,Xiong Guan, Kaihui Hu, Yaling Shen*,A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30,Applied Microbiology and Biotechnology,2014,98, 1175-1184
7. Jian-An Sun, Liao-Yuan Zhang, Ben Rao, Ya-Ling Shen* et al, Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase,Bioresource Technology,2012,119,94-98
8. Jianan Sun, Ben Rao, Liaoyuan Zhang, Yaling Shen* et al, Extraction of acetoin from fermentation broth using an acetone/phosphate aqueous two-phase system, Chemical Engineering Communications,2012, 199(11), 1492-1503
9. Jianan Sun,Liaoyuan Zhang, Ben Rao,Yaling Shen* et al,Enhanced acetoin production by Serratia marcescens H32 using statistical optimization and two-stage agitation speed control strategy,Biotechnology and Bioprocess Engineering,2012,17(3),598-605
10. Ben Rao,Liao Yuan Zhang,Jian’an Sun,Yaling Shen* et al,Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens,Applied Microbiology and Biotechnology,2012,93(5),2147-2159
11. Xiangzhao Mao,Shi Chen,Yaling Shen*,Dongzhi Wei*,Zixin Deng,Effect of copper sulfate on biosynthesis of FR-008/Candicidin complex production in Streptomyces sp.,World Journal of Microbiology and Biotechnology,2011,27(9),2033–2039