个人简介
学历 1995. 9 ～ 1999. 7 华东理工大学 生物化工专业 博士研究生 1992. 9 ～ 1995. 7 华东理工大学 生物化学专业 硕士研究生 1989. 9 ～ 1992. 7 华东化工学院 生物化工专业 本科
工作经历 2011. 9 ～ 至今 华东理工大学 生物工程学院 研究员 2006. 9 ～ 2011. 8 华东理工大学 生物工程学院 副研究员 2005. 10 ～ 2006. 8 华东理工大学 生物工程学院 助理研究员 2003. 9 ～ 2005. 9 美国宾夕法尼亚大学（university of Pennsylvania）医学院 博士后 1995. 7 ～ 2003. 8 华东理工大学 生物工程学院 助教/助理研究员
研究领域
1．代谢工程：优化遗传操作手段，应用代谢调控和系统分析，结合高通量筛选和分析，优化和构建微生物细胞工厂。
2．生物材料的生物效应：纳米无机材料抗肿瘤及其机理研究
近期论文
1. Wu YQ, Tang W, Wang P, Liu CS, Yuan Y*, Qian JC*. Cytotoxicity and cellular uptake of amorphous silica nanoparticles in human cancer cells. Part. Part. Syst. Charact., 2015, 32(7): 779-787.
2.Tang W, Yuan Y, Liu CS, Wu YQ, Lu X, Qian JC*. Differential cytotoxicity and particle action of hydroxyapatite nanoparticles in human cancer cells. Nanomedicine, 2014, 9(3): 397-412.
3. Yao GF, Qin XL, Chu J, Wu XL, Qian JC*. Expression, purification and characterization of a recombinant methionine adenosyltransferase pDS16 in Pichia pastoris. Appl. Biochem. Biotech., 2014, 172(3): 1241-1253.
4. Nie YS, Huang MZ*, Lu JJ, Qian JC, Lin WL, Chu J, Zhuang YP, Zhang SL. Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis. J. Biotechnol., 2014, 187: 124-134.
5. Liang T, Qian JC, Yuan Y*, Liu CS*. Synthesis of mesoporous hydroxyapatite nanoparticles using a template-free sonochemistry-assisted microwave method. J. Mater. Sci., 2013, 48 (5): 5334–5341.
6. Chu J*, Qian JC, Zhuang YP, Zhang SL, Li YR. Progress in the research of S-adenosyl-L-methionine production.Appl. Microbiol. Biotechnol., 2013, 97 (1): 41-49.
7. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL, Chu J*. GAP promoter library for fine-tuning gene expression inPichia pastoris. Appl. Environ. Microb., 2011, 77(11): 3600-3608.
8. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL,Chu J*. Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Lett. Appl. Microbiol. 2011, 52(6): 634-641.
9. Lu X, Qian JC, Zhou HJ, Gan Q, Tang W, Lu JX, Yuan Y*, Liu CS*. In vitro cytotoxicity and apoptosis-induction of silica nanoparticles in human hepatoma HepG2 cells. Int. J. Nanomed., 2011, 6: 1889-1901.
10. Wu JQ, Zhang QL, Deng W, Qian JC, Zhang SL, Liu W*. Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Appl. Environ. Microb., 2011, 77 (21): 7508-7516.
11. Gan Q, Lu XY, Yuan Y*, Qian JC, Zhou HJ, Lu X, Shi JL, Liu CS*. A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles- capped mesoporous silica. Biomaterials, 2011, 32 (7): 1932-1942.
12. Qian JC, Qin XL, Yin Q, Chu J, Wang YH*. Cloning and characterization of Kluyveromyces marxianus Hog1 gene. Biotechnol. Lett. 2010, 33(3): 571-575.
13. Zhang QL, Wu JQ, Qian JC*,Chu J, Zhuang YP, Zhang SL, Liu W*. Knocking out of tailoring genes eryK and eryGin an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C, and D at different conversion ratios. Lett. Appl. Microbiol. 2010, 52: 129-137.
14. Zhao QH, Qian JC*, Zhou HJ, Yuan Y, Mao YH, Liu CS*. In vitro osteoblast-like and endothelial cells' response to calcium silicate/calcium phosphate cement. Biomed. Mater. 2010, 5(3): 035004.
15. Zhang SL*,Cao XJ,Chu J, Qian JC, Zhuang YP. Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Envronment. Advances in Biochemical Engineering-Biotechnology, 2010, 122: 105-150.
16. Zou X*, Zeng W, Chen CF, Qi XC, Qian JC, Chu J, Zhuang YP, Zhang SL, Li WJ. Fermentation optimization and industrialization of recombinant Saccharopolyspora erythraea strains for improved erythromycin A production. Biotechnol. Bioproc. E, 2010, 15 (6): 959-968.
17. Hu H, Qian JC*,Chu J*, Wang Y, Zhuang YP, Zhang SL. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J. Biotechnol., 2009, 141(3-4): 97-103.
18.Hu H, Qian JC*,Chu J*, Wang YH, Zhuang YP, Zhang SL. Optimization of L-Methionine feeding strategies for improving S-adenosyl-Lmethionine production by methionine adenosyltransferase overexpressed Pichia pastoris. Appl. Microbiol. Biotechnol., 2009, 83(6): 1105-1114.
19. Zhou HJ, Qian JC, Wang J, Yao WT, Liu CS*, Chen JG andCao XH.Enhancedbioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo. Biomaterials, 2009, 30 (9): 1715-1724.
20. Chen Y, Deng W, Wu JQ, Qian JC,Chu J, Zhuang YP, Zhang SL*, Liu W*. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Appl. Environ. Microb., 2008, 74 (6): 1820-1828.
21. Qian JC, Lavker RM, Tseng H*. Mapping ribosomal RNA transcription activity in the mouse eye. Dev. Dynam.2006, 235(7): 1984-1993.
22. Qian JC*, Cai XP,Chu J, Zhuang YP, Zhang SL. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Biotechnol. Lett. 2006, 28(12 ): 937-941