2004年毕业于清华大学生物科学与技术系，获理学学士学位。同年赴美密歇根大学分子、细胞与发育生物学系攻读博士学位。2010年获得博士学位并于密歇根大学及霍华德休斯医学研究所从事博士后研究工作。代表性研究成果发表在  Elife、Nature Structural & Molecular Biology、 Journal of Biological Chemistry等期刊上。2013年11月加入华东理工大学生物工程学院，建立“蛋白质工程”课题组。2014年入选上海市浦江学者，2015年入选华东理工大学第二批“青年英才引进与培育计划”，同年获国家自然科学基金青年基金资助及华东理工大学杰出青年人才培育基金资助

1) 发展新型蛋白质体内稳定性检测探针，打造提升蛋白质稳定性的高通量筛选平台，优化一些工业上、医药上迫切需要的蛋白质的稳定性。

2) 以提升组蛋白H3K4甲基转移酶家族的稳定性为切入点，解析结构灵活性与其催化活性间的关系，阐述其被其他蛋白质复合物激活的机制，为以此家族蛋白为靶点的药物设计提供新思路。

3) 发现与鉴定新型分子伴侣蛋白，阐释其作用机理，并借助结构生物学手段研究分子伴侣蛋白和底物的相互作用

Quan, S., Wang, L., Petrotchenko, E. V., Makepeace, K. A., Horowitz, S., Yang, J., Zhang, Y., Borchers, C. H., and Bardwell, J. C. (2014) Super Spy variants implicate flexibility in chaperone action. eLife 3, e01584

Quan, S., Hiniker, A., Collet, J. F., and Bardwell, J. C. (2013) Isolation of bacteria envelope proteins. Methods in molecular biology 966, 359-366

Quan, S.*, and Bardwell, J. C. (2012) Chaperone discovery. BioEssays : news and reviews in molecular, cellular and developmental biology 34, 973-981. *corresponding author

Quan, S., Koldewey, P., Tapley, T., Kirsch, N., Ruane, K. M., Pfizenmaier, J., Shi, R., Hofmann, S., Foit, L., Ren, G., Jakob, U., Xu, Z., Cygler, M., and Bardwell, J. C. (2011) Genetic selection designed to stabilize proteins uncovers a chaperone called Spy. Nature structural & molecular biology 18, 262-269

Evans, M. L., Schmidt, J. C., Ilbert, M., Doyle, S. M., Quan, S., Bardwell, J. C., Jakob, U., Wickner, S., and Chapman, M. R. (2011) E. coli chaperones DnaK, Hsp33 and Spy inhibit bacterial functional amyloid assembly. Prion 5, 323-334

Masip, L., Klein-Marcuschamer, D., Quan, S., Bardwell, J. C., and Georgiou, G. (2008) Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant. The Journal of biological chemistry 283, 840-848

Chen, Y., Pan, X., Tang, Y., Quan, S., Tai, P. C., and Sui, S. F. (2008) Full-length Escherichia coli SecA dimerizes in a closed conformation in solution as determined by cryo-electron microscopy. The Journal of biological chemistry 283, 28783-28787

Quan, S., Schneider, I., Pan, J., Von Hacht, A., and Bardwell, J. C. (2007) The CXXC motif is more than a redox rheostat. The Journal of biological chemistry 282, 28823-28833

Chen, Y., Lu, Y. J., Wang, H. W., Quan, S., Chang, Z., and Sui, S. F. (2003) Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layer. Biochemical and biophysical research communications 310, 360-366