马兴元 照片

马兴元

教授 博导

所属大学: 生物反应器工程国家重点实验室

所属学院: 未知

邮箱:
maxy@ecust.edu.cn

个人主页:
http://sklbe.ecust.edu.cn/Web/Show?w=146&p=106&f=448

个人简介

2003年6月毕业于中国人民解放军军需大学(现吉林大学) 获动物医学博士学位,师从殷震院士、朱平研究员。硕士与博士期间在军需大学研究所 (军事医学科学院 第11所) 全军基因工程重点实验室从事分子生物学与基因工程药物研究。2003年博士毕业后在华东理工大学生物工程博士后流动站从事博士后研究工作,2010.12- 2011.12在新加坡国立大学 MIT-NUS联合研究所 国家公派(A类)访问学者。第13届国际生物技术大会(大连)(2008年)国际生物技术青年科学家奖、上海市生物工程学会 青年科学家学术年会(2008)刘新垣院士征文一等奖等。2013年上海市“浦江学者”人才计划项目获得者。

研究领域

微生物免疫学及分子与细胞生物学基础研究; 生物技术创新药物(疫苗/抗体/细胞制剂)研发

近期论文

GuoyingDai, Wenyun Zheng, Xingyuan Ma*.Multisite Mutation of Monomer Survivin with Enhanced Effect on Apoptosis Regulation of Breast Cancer Cells. Biomed Pharmacother.2015,69(2):111-118

Tianwen David Wang & Fei Ma & Xingyuan Ma. Spatially programmed assembling of oxidoreductases with single-stranded DNA for cofactor-required reactions. Appl Microbiol Biotechnol.2015,99(8):3469-3477

Fei Ma,Tianwen Wang, Xingyuan Ma*. Identification and Characterization of the Protein Encoded by orf382 as an L-Threonine Dehydrogenase. J. Microbiol. Biotechnol. 2014, 24(6): 748–755

Liqun Wang, Yanyan Kang, Wenyun Zheng*, Linfeng Li, Lei Shi, Xingyuan Ma.Effect on apoptosis and cell cycle of recombinant double negative 4 dominant mutation Survivin (T34/117A) in breast cancer cell B-Cap-37. Biomedicine & Pharmacotherapy, 2014, 68(3):277–284

Nanjing Lin, Wenyun Zheng, Linfeng Li, Xingyuan Ma*, A novel system enhancing the endosomal escapes of peptides promotes Bak BH3 peptide inducing apoptosis in lung cancer A549 cells. Targeted Oncology. 2014, 9(2): 163-170

Tianwen Wang, Xingyuan Ma*, Hu Zhu, Aitao LI, Guocheng Du, Jian Chen. Available methods for assembling expression cassettes for synthetic biology. Applied Microbiology and Biotechnology. Appl Microbiol Biotechnol. 2012 93(5): 1853–1863.

Li Hui, Zhang Qian, Wang Xiao li, Ma Xing yuan*, Lin Kuang fei*, Liu Yong di, Gu Ji dong. Biodegradation of benzene homologues in contaminated sediment of the East China Sea. Bioresource Technology, 2012, 124: 129-136.

Rijun Gui, Xueqin An*, Hongjuan Su, Weiguo Shen, Linyong Zhu, Xingyuan Ma, Zhiyun Chen, Xiaoyong Wang..Rhodamine 6G conjugated-quantum dots used for highly sensitive and selective ratiometric fluorescence sensor of glutathione. Talanta, 2012, 94 (5) 295-300.

Yuxin Xu, Wenyun Zheng, Tianwen Wang, Ling Zhu, Xingyuan Ma*. Genetic protein TmSm(T34A) enhances sensitivity of chemotherapy to breast cell lines as a synergistic drug to doxorubicin. Biomedicine & Pharmacotherapy, 2012, 66 (5): 368-372.

Hailong Chen, Xingyuan Ma*, Zhi Li, Qiaoyun Shi, Wenyun Zheng, Yang Liu. Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth. Biomedicine & Pharmacotherapy, 2012, 66 (5):334-338.

Wang T, Ma X*, Du G, Chen J. Overview of Regulatory Strategies and Molecular Elements in Metabolic Engineering of Bacteria. Mol Biotechnol. 2012, 52(3): 300-308.

Dan Qiu, Xueqin An*, Zhiyun Chen, Xingyuan Ma. Microstructure study of liposomes decorated by hydrophobic magnetic nanoparticles. Chemistry and Physics of Lipids. 2012,165 (5):563-570.

Wang T, Li A, Ma X*, DU G, Chen J. A simple and universal method to express protein in unfused form. Protein Pept Lett. 2012, 19(9): 930-933.

Wenyun Zheng, Yanyan Kang, Linfeng Li, Yuxin Xu, Xingyuan Ma*, Levels of effectiveness of gene therapies targeting survivin and its splice variants in human breast cancer cells. Drug Discoveries & Therapeutics. 2011; 5(6):293-298.

Xingyuan Ma, Bi Yao, Wenyun Zheng, Linfeng Li*. Comparative study on characterization of recombinant B subunit of E. coli heat-labile enterotoxin (rLTB) prepared from E. coli and P. patoris. J. Microbiol. Biotechnol. 2010, 20(3):550-557.

Haiyi Zhang, Yu Zheng, QinghaiLiu, Xinyi Tao, Wenyun Zheng, Xingyuan Ma*, Dongzhi Wei*. Development of a fed-batch process for the production of anticancer drug TATm-survivin(T34A) in Escherichia coli. Biochemical Engineering Journal. 2009, 43(2):163–168.

Li Zhao, Yu Zheng, Xingyuan Ma* and Dongzhi Wei*. Effects of over-expression of glycerol dehydrogenase and 1, 3-propanediol oxidoreductase on bioconversion of glycerol into 1, 3-propandediol by Klebsiella pneumoniae under micro-aerobic conditions. Bioprocess and Biosystems Engineering, 2009, 32(3): 313-320.

Li Zhao, Xingyuan Ma, Yu Zheng, Jianguo Zhang, Guodong Wei, Dongzhi Wei. Over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase in Klebsiella pneumoniae and their effects on conversion of glycerol into 1, 3-propanediol in resting cell system. Journal of Chemical Technology & Biotechnology. 2009, 84(4): 626-632.

Yu Zheng, Li Zhao, Xingyuan Ma, Dongzhi Wei*. Production of 1, 3-propanediol from glucose by co-expressing glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase in Klebsiella pneumoniae. Journal of Bioscience and Bioengineering, 2008, 105 (5): 508–512.

Xingyuan Ma, Meiyun Liu, Yushu Ma, Yi Gong *, Dongzhi Wei*, Shengli Yang. Disulfide bond Cys30-Cys299 and the fragment “96RIMQAPLT106”of the lid region of lip2 are critical for its biocatalytic activity. Journal of Biotechnology. 2008, S290-334 (V1-Y-046).