李志敏
教授 博导
所属大学: 生物反应器工程国家重点实验室
所属学院: 未知
个人简介
学历 1991年7月 毕业于华东理工大学,生物化工专业,学士 2001年7月 毕业于华东理工大学,生物化工专业,博士
工作经历 2002年7月-2004年6月 中科院上海生命科学院生化与细胞所,博士后 2004年6月-2007年2月 华东理工大学生物反应器工程国家重点实验室,生物工程学院 2007年2月-2009年1月 华盛顿州立大学生物系统工程系,博士后 2009年1月至今 华东理工大学生物反应器工程国家重点实验室,生物工程学院
研究领域
1. 微生物(大肠杆菌,谷氨酸棒杆菌、酿酒酵母等)合成平台化合物和生物活性物质 2. 废弃资源(CO2、乙酸等)循环利用 3. 发酵过程优化与放大
近期论文
1. JH Yang, W Li, DZ Wang, H Wu*, ZM Li*, Q Ye. 2016. Characterization of bifunctional L-glutathione synthetases from Actinobacillus pleuropneumoniae and Actinobacillus succinogenes for efficient glutathione biosynthesis. Applied Microbiology and Biotechnology. DOI: 10.1007/s00253-016-7437-4. (*Co-corresponding) 2. J Zhang, C Quan, C Wang, H Wu*, ZM Li*, Q Ye. 2016. Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production. Microbial Cell Factories. 15:38. (*Co-corresponding) 3. Z Cheng, JQ Jiang, H Wu, ZM Li*, Q Ye. 2016. Enhanced production of 3-hydroxypropionic acid from glucose via malonyl-CoA pathway by engineered Escherichia coli. Bioresource Technology. 200: 897-904. 4. DZ Wang, C Wang, H Wu*, ZM Li*, Q Ye. 2016. Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase. Journal of Industrial Microbiology and Biotechnology. 43:45-53. (*Co-corresponding) 5. Q Ye*, ZM Li, H Wu. 2016. Principle and performance of gas self-inducing reactors and applications to biotechnology. Advances in Biochemical Engineering/Biotechnology. 152:1-33 6. C Wang, J Zhang, H Wu*, ZM Li*, Q Ye. 2015. Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production. Journal of Biotechnology. 214:63-68. (*Co-corresponding). 7. YL Yi, HK Sheng, ZM Li*, Q Ye. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnology, 2014, 14: 44. 8. CX Chen, SP Ding, DZ Wang, ZM Li*, Q Ye. Simultaneous saccharification and fermentation of cassava to succinic acid by Escherichia coli NZN111. Bioresource Technology, 2014, 163: 100-105. 9. RR Shi, ZM Li*, Q Ye, JH Xu. Heterologous expression and characterization of a novel thermo-halotolerant endoglucanase Cel5H from Dictyoglomus thermophilum. Bioresource Technology, 2013, 142: 338-344. 10. YN Huang, ZM Li*, K Shimizu, Q Ye*. Co-production of 3-hydroxypropionic acid and 1,3-propanediol by Klebseilla pneumoniae expressing aldH under microaerobic conditions. Bioresource Technology, 2013, 128: 505-512. (*Co-corresponding) 11. H Wu, Q Li, ZM Li*, Q Ye*. Succinic acid production and CO2 fixation using a metabolically engineered Escherichia coli in a bioreactor equipped with a self-inducing agitator. Bioresource Technology, 2012, 107: 376-384. (*Co-corresponding) 12. YN Huang, ZM Li*, K Shimizu, Q Ye*. Simultaneous production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol by a recombinant strain of Klebsiella pneumoniae. Bioresource Technology, 2012, 103: 351-359. (*Co-corresponding) 13. CL Fan, ZM Li*, Q Ye*. Two-Stage Cultivation of Pseudomonas sp. F12 for the production of enzymes converting DL-2-amino-Δ2-thiazoline-4-carboxylic acid to L-cysteine. Applied Biochemistry and Biotechnology, 2012, 168: 1867-1879. (*Co-corresponding) 14. W Li, ZM Li*, JH Yang, Q Ye*. Production of glutathione using a bifunctional enzyme encoded by gshF from Streptococcus thermophilus expressed in Escherichia coli. Journal of Biotechnology, 2011, 154: 261-268. (*Co-corresponding) 15. ZM Li, Y Liu, W Liao, SL Chen*, RS Zemetra. Bioethanol production using genetically modified and mutant wheat and barley straws. Biomass and Bioenergy, 2011, 35: 542-548.