卢艳花
教授 博导
个人简介
1999年7月毕业于中国药科大学中药学院,获理学博士学位;1999年至2001年在南京大学生命科学学院作博士后研究工作;2002年3月至今,华东理工大学生物工程学院工作,现任分管研究生工作副院长,生物反应器工程国家重点实验室中药生物工程研究室主任。主要承担过上海市科委项目“中药化学对照品的制备及中药材指纹图谱研究”部分工作;863重大项目“海洋共生菌活性物质的高效利用”子课题;国家自然科学基金项目“水翁花逆转肝癌多药耐药有效成分及作用机制”;上海-联合利华研究与发展基金项目“具有抑癌活性柑橘黄酮的吸收代谢研究”以及与雀巢公司、联合利华公司国际合作、相宜本草等企业委托项目等近20项课题。目前正承担863课题子项目“海洋微生物来源选择性免疫抑制剂FC大规模发酵制备工艺研究”、“海洋微生物先导化合物的生物合成调控与产率优化”;中央高校基本科研业务费交叉学科与重大项目培育基金项目“农业废弃物资源循环利用与农产品深加工”、以及与联合利华、相宜本草等企业合作课题。
国内外进修留学情况 2001.2-2001.8 香港中文大学生物系 访问学者 1999.1-1999.6 香港中文大学生物化学系 访问学者
研究领域
中草药及海洋微生物资源的开发利用;生物工程技术(发酵工程、酶工程、基因工程、细胞工程)在植物药及海洋微生物先导化合物研究中的应用;中药活性成分(或标准提取物)的制备、质量标准的制定、生物活性及其作用机理;具有知识产权的、创新的现代化中药的研究开发;天然功能成份在化妆品、健康食品、饲料添加剂中的应用及作用机制研究
近期论文
Zheng-Hua Pan, Rui-Hua Jiao, Yan-Hua Lu*, Ren-Xiang Tan. Enhancement of dalesconols A and B production via upregulation of laccase activity by medium optimization and inducer supplementation in submerged fermentation of Daldinia eschscholzii. Bioresource Technol, 2015, 192: 346–353. (IF4.494)
Jing Wang, Jie Qian, Ling-Yun Yao*, Yan-Hua Lu*. Enhanced production of flavonoids by methyl jasmonate elicitation in cell suspension culture of Hypericum perforatum. Bioresources & Bioprocessing. 2015, 2: 5. (DOI 10.1186/s40643-014-0033-5)
Ling-Yun Yao, Yi-Xiang Zhu, Chang-Qing Liu, Rui-Hua Jiab, Yan-Hua Lu*, Ren-Xiang Tan*. Preparative separation and purification of fumigaclavine C fromfermented mycelia of Aspergillus fumigatus CY018 by macroporousadsorption resin. J Chromatogr B, 2015, 989: 122–128. (IF2.729)
Zhong-Xin Zhou, Da-Fu Wei, Yan-Hua Lu*. Polyhexamethylene guanidine hydrochloride shows bactericidal advantages over chlorhexidine digluconate against ESKAPE bacteria. Biotechnol Appl Bioc, 2014: 1-7. (IF1.362)
Wan-Guo Yu, Hao He, Jie Qian, Yan-Hua Lu*. Dual Role of 2’,4’-Dihydroxy-6’-Methoxy-3’,5’-Dimethylchalcone in Inhibiting High-Mobility Group Box 1 Secretion and Blocking Its Pro-inflammatory Activity in Hepatic Inflammation. J Agric Food Chem, 2014, 62: 11949?11956. (IF3.107)
Wen-Bo Han, Yan-Hua Lu, Ai-Hua Zhang, Gao-Fei Zhang, Ya-Ning Mei, Ren Xiang Tan*. Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species. Org Lett, 2014, 16: 5366?5369. (IF6.364)
Jun-Peng Yang, Hao He, Yan-Hua Lu*. Four Flavonoid Compounds from Phyllostachys edulis Leaf Extract Retard the Digestion of Starch and Its Working Mechanisms. J Agric Food Chem, 2014, 62: 7760?7770. (IF3.107)
Ying-Chun Hu, Dong-Ming Hao, Lu-Xian Zhou, Yan-Hua Lu*. 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone Protects the Impaired Insulin Secretion Induced by Glucotoxicity in Pancreatic β?Cells. J Agric Food Chem, 2014, 62 (7): 1602-1608. (IF3.107)
Ying-Chun Hu, Zhe Zhang, Wei-Gang Shi, Yan-Hua Lu*. 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone Promoted Glucose Uptake and Imposed Paradoxical Effect on Adipocyte Differentiation in 3T3-L1 Cells. J Agric Food Chem, 2014, 62 (8): 1898-1904. (IF3.107)
Yi-Xiang Zhu, Ling-Yun Yao, Rui-hua Jiao, Yan-hua Lu*, Ren-Xiang Tan*. Enhanced production of fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process. Bioresource Technol, 2014, 152: 162-168. (IF4.494)
Yue Lu, Yan-Yan Zhang, Ying-Chun Hu, Yan-Hua Lu*. Protective effects of2’,4’- dihydroxy-6’-methoxy-3’,5’-dimethylchalcone against hydrogen peroxide-inducedoxidative stress in hepatic L02 cell. Arch Pharm Res, 2014, 37: 1211-1218. (IF1.751)
Ling-Yun Yao, Yi-Xiang Zhu, Rui-Hua Jiao, Yan-Hua Lu*, Ren-Xiang Tan*. Enhanced production of fumigaclavine C by ultrasound stimulation in a two-stage culture of Aspergillus fumigatus CY018. Bioresource Technol, 2014, 159: 112-117. (IF4.494)
Hao He, Yan-Hua Lu*. Comparison of Inhibitory Activities and Mechanisms of Five Mulberry Plant Bioactive Components against α?Glucosidase. J Agric Food Chem, 2013, 61: 8110?8119. (IF2.906)
Shu-Long Yao, Ying Xu, Yan-Yan Zhang, Yan-Hua Lu*. Black rice and anthocyanins induce inhibition of cholesterol absorption in vitro. Food & Function, 2013, 4: 1602–1608. (IF2.694)
Jie Wang, Ling-yun Yao, Yan-hua Lu*. Ceriporia lacerata DMC1106, A New Endophytic Fungus: Isolation,Identification, and Optimal Medium for 2',4' – dihydroxy - 6' – methoxy - 3',5' - dimethylchalcone Production. Biotechnol Bioproc E, 2013, 18: 669-678. (IF1.113)
Ying Xu, Zhang Zhang, Lin Li, Yan-Hua Lu*. Catechins play key role in green tea extract–induced postprandial hypoglycemic potential in vitro. Eur Food Res Technol, 2013, 237: 89-99. (IF1.436)
Wei Shen, Yan-Hua Lu*. Molecular docking of citrus flavonoids with some targets related to diabetes. Bangl J Pharmacol, 2013, 8: 156-170. (IF0.356)
Jie Qian, Jun-Yu Wu, Bing-Bo Yao, Yan-Hua Lu*. Preparation of a polyclonal antibody against hypericin synthase and localization of the enzyme in red-pigmented Hypericum. Acta biochimica, 2012, 59 (4): 639-645. (IF1.491)
Ying-Chun Hu, Ying-Di Luo, Lin Li, Yan-Hua Lu*. In-vitro investigation of 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone for glycemic control. J Agric Food Chem, 2012, 60: 10683-10688. (IF2.823)
Li-Na Zhang, Yan-Hua Lu*. Inhibitory activities of extracts from Cleistocalyx operculatus flower buds on pancreatic lipase and a-amylase. Eur Food Res Technol, 2012, 235 (6): 1133-1139. (IF1.59)