学历 2002/3-2005/7，华东理工大学，发酵工程，博士，导师：张元兴 1999/9-2002/2，南京农业大学，生物技术，硕士，导师：李式军 1995/9-1999/6，南京农业大学，生物技术，学士，导师：李式军

工作经历 2002/03-2005/06，华东理工大学生物工程学院博士研究生，师从张元兴教授，期间主要从事重要海洋病原鳗弧菌的毒力基因研究，主要参与了国家863计划项目“海洋鳗弧菌减毒活菌疫苗的研制”（2003AA622020），获工学博士学位。 2005/07-2007/06，华东理工大学生物工程学院，讲师，期间主要从事重要海洋病原溶藻弧菌的毒力机制研究，主要参与了国家自然科学基金项目“海洋溶藻弧菌群体感应功能基因鉴定及致病相关性研究”（30571435）。 2007/07-2012/06，华东理工大学生物工程学院，副教授，硕士生导师，2010年破格晋升为博士生导师。期间主要从事重要鱼类多效价载体疫苗的分子设计，主持了国家863计划“鱼类疫苗导入系统研究及多效价载体疫苗开发”等多项课题。 2011/03-20011/09，美国亚利桑那州立大学疫苗研究中心，访问学者，在美国科学院院士Roy Curtiss III教授实验室开展细菌疫苗免疫保护机制研究。与Roy Curtiss III教授建立科研合作关系，Roy Curtiss III教授同年受聘为华东理工大学荣誉教授。 2012/07-至今，华东理工大学生物工程学院，教授，博士生导师，期间主要从事重要海洋病原细菌的致病机理研究及疫苗开发，参与了国家863计划“迟钝爱德华氏菌活疫苗的应用研究和产业化开发”等多项课题，在细菌感染机制及疫苗开发方面取得突破性进展。 2014/12-2015/01，美国密西根州立大学医学院，访问学者，在感染与免疫研究领域国际权威专家Gabriel Núñez教授实验室开展细菌调控宿主炎症小体通路的研究，与对方实验室建立了科研合作

病原细菌毒力因子及其与宿主免疫系统的互作机制研究 新型疫苗的分子设计及临床应用研究

Lingzhi Zhang; Chunshan Ni; Wenting Xu; Tongcheng Dai; Dahai Yang; Qiyao Wang; Yuanxing Zhang; *Qin Liu. Intra-macrophage infection reinforces the virulence of Edwardsiella tarda. Journal of Bacteriology 2016 (accepted)

Dahai Yang, Yuan He, Raul Muñoz-Planillo, Qin Liu*, Gabriel Núñez* A critical pannexin-1/P2X7 signaling axis downstream of caspase-11 for pyroptosis and susceptibility to endotoxic shock. Immunity 2015 43(5): 923-932

Tongcheng Dai; Na Li; Fajun Han,; Hua Zhang; Yuanxing Zhang; *Qin Liu. AMP-guided tumour-specific nanoparticle delivery via adenosine A1 receptor. Biomaterials 2016, 83: 37-50

Tongcheng Dai; Tongcheng Dai; Na Li,; Yuanxing Zhang; *Qin Liu. A new target ligand Ser-Glu for pancreatic cancer imaging via PEPT1 transporter. International Journal of Nanomedicine 2016,11: 203-212

Teng Chu, Lingyu Guan, Pengfei Shang, Qiyao Wang, Jingfan Xiao, Qin Liu*, Yuanxing Zhang. A controllable bacteria lysis system to enhance biological safety of live attenuated Vibrio anguillarumvaccine. Fish & Shellfish Immunology 2015, 45(2): 742~749.

Tongcheng Dai,; Na Li; Lu Liu; *Qin Liu; Yuanxing Zhang. AMP-Conjugated Quantum Dots: Low Immunotoxicity Both In Vitro and In Vivo. Nanoscale Research Letters, 2015 10(1):1-9.

Teng Chu, Chunshan Ni, Lingzhi Zhang, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang, Qin Liu*. A quorum sensing-based in vivo expression system and its application in multivalent bacterial vaccine. Microbial Cell Factories 2015, 14: 37.

Teng Chu, Yajun Huang, Mingyu Hou, Qiyao Wang, Jingfan Xiao, Qin Liu*, Yuanxing Zhang. In vivoprogrammed gene expression based on artificial quorum networks. Applied and Environmental Microbiology 2015, 81(15): 4984~4992

Sanying Wang, Qin Liu*, Menghao Cai, Qiyao Wang, Yuanxing ZhangFermentation preparation of recombinant Vibrio anguillarum vaccine with heterogeneous antigen display. Preparative Biochemistry and Biotechnology 2013 43(1): 79~94.

Yijian Yan, Wei Mu, Lingzhi Zhang, Lingyu Guan, Qin Liu*, Yuanxing Zhang Asd-based balanced-lethal system in attenuated Edwardsiella tarda to express a heterologous antigen for a multivalent bacterial vaccine. Fish and Shellfish Immunology 2013 34(5):1188~1194.

Dahai Yang, Qin Liu*, Chunshan Ni, Shuai Li, Haizhen Wu, Qiyao Wang, Jinfan Xiao, Yuanxing. ZhangGene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish. Developmental and Comparative Immunology 2013, 40(2): 132~141.

Lingyu Guan, Qin Liu*, Chao Li, Yuanxing Zhang Development of a Fur-dependent and tightly regulated expression system in Escherichia coli for toxic protein synthesis. BMC Biotechnology 2013,13: 25.

Dahai Yang, Qin Liu*, Mingjun Yang, Haizhen Wu, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang* RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics 2012 13: 319.

Yan Zheng, Yan Xiao, Haizhen Wu, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang, Qin Liu* Different approaches to expressing Edwardsiella tarda antigen GAPDH in attenuated Vibrio anguillarum for multivalent fish vaccines. Journal of Fish Diseases 2012 35(8): 569~577.

Lingyu Guan, Wei Mu, Jonathan Champeimont, Qiyao Wang, Haizhen Wu, Jingfan Xiao, Werner Lubitz, Yuanxing Zhang, Qin Liu* Iron-regulated lysis of recombinant Escherichia coli in host releases protective antigen and confers biological containment. Infection and Immunity 2011 79(7): 2608~2618.

Yan Xiao, Qin Liu*, Hao Chen, Yuanxing Zhang A stable plasmid system for heterologous antigen expression in attenuated Vibrio anguillarum. Vaccine 2011 29(40): 6986~6993.

Wei Mu, Lingyu Guan, Yijian Yan, Qin Liu*, Yuanxing Zhang A novel in vivo inducible expression system in Edwardsiella tarda for potential application in bacterial polyvalence vaccine. Fish & Shellfish Immunology 2011 31(6): 1097~1105.

Yan Zhao, Qin Liu*, Xiuhua Wang, Lingyun Zhou, Qiyao Wang, Yuanxing Zhang* Surface display of Aeromonas hydrophila GAPDH in attenuated Vibrio anguillarum to develop a novel multivalent vector vaccine. Marine Biotechnology 2011 13(5): 963~970.

Xiaodan Cao, Qiyao Wang, Qin Liu*, Haopeng Rui, Huan Liu, Yuanxing Zhang* Identification of a luxO-regulated extracellular protein Pep and its roles in motility in Vibrio alginolyticus. Microbial Pathogenesis 2011 50(2):123~131.

Honghong He, Qiyao Wang, Lili Sheng, Qin Liu*, Yuanxing Zhang* Functional characterization of Vibrio alginolyticus twin-arginine translocation system: its roles in stress adaptation and virulence towards fish. Current Microbiology 2011 62(4): 1193~1199.