1994年毕业于上海中医药大学肿瘤治疗学专业，获得医学博士学位；1995年应日本国科学技术厅邀请，作为STA Fellow在大阪生物科学研究所（Osaka Bioscience Institute）和日本理化学研究所（Institute of Physical and Chemical Research）进行客座研究。研究天然药物对血管内皮细胞纤溶活性因子的基因调空作用。2001年毕业于日本广岛大学(省立)遗传子制御工学研究室

分子细胞药理学，毒理学，肿瘤学，细胞生物学，分子生物学，中药学。现主要研究方向：细胞周期阻滞及凋亡诱导剂的发现与作用机理研究；肿瘤细胞凋亡小RNA表达、调控的研究及其在新药研发中的应用；基于肿瘤光动力的分子模型的建立及先导化合物的发现研究；纳米材料与技术在生命科学中的应用基础研究

分子细胞药理学，毒理学，肿瘤学，细胞生物学，分子生物学，中药学

1.Shengchao Lin, Kecheng Lei, Wenpei Du, Liyan Yang, Haiyang Shi, Yuwei Gao, Peihao Yin, Xin Liang, Jianwen Liu*: Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. The International Journal of Biochemistry & Cell Biology 2016,71: 24-34

2.Yuanhong Zheng, Guifang Yin, Vanminh Le, Anle Zhang, Peihao Yin, Jianwen Liu*, Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, Which Generates Vaccine for Cancer Therapy Int J Biol Sci 2016; 12(1): 120-132

3. Liyan Yang, Qiannan Liang, Ke Shen, Li Ma, Na An, Weiping Deng, Zhewei Fei, Jianwen Liu:A novel class I histone deacetylase inhibitor, I-7ab, induce apoptosis and arrest cell cycle progression in human colorectal cancer cells. Biomedicine & Pharmacotherapy 2015,71: 70-78

4. Van-Minh Le, Jing-Jing Wang, Ming Yuan, The-Long Nguyen, Gui-Fang Ying, Yuan-Hong Zheng, Wei-Bin Shi, Mei-Dong Lang, Lei-Ming Xu, Jian-Wen Liu: An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil Nanoparticles. European Journal of Medicinal Chemistry 2015, 92: 882-889

5. Yuanhong Zheng, Fangyuan Zou, Jingjing Wang, Guifang Yin, Vanminh Le, Zhewei Fei, and Jianwen Liu*: Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein. J Biol Chem. 2015, 290: 8975-8986.

6. Kecheng Lei & Shaoying Tan & Wenpei Du & Yichun Xu & Shengchao Lin & Yuanhong Zheng & Fangyuan Zou &Yufang Xu & Jianwen Liu:3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells. Tumor Biol. 2015, 36:5597–5606

7. Rurong Mao, Fangyuan Zou, Liyan Yang, Shengchao Lin, Yueqi Li, Mingxing Ma, Peihao Yin, Xin Liang, Jianwen Liu*: The Loss of MiR-139-5p Promotes Colitis-Associated Tumorigenesis by Mediating PI3K/AKT/Wnt Signaling International Journal of Biochemistry and Cell Biology 2015,69:153–161

8. Li Ma, Rurong Mao, Ke Shen, Yuanhong Zheng, Yueqi Li, Jianwen Liu*, Lei Ni: Atractylenolide I-mediated Notch Pathway Inhibition Attenuates Gastric Cancer Stem Cell Traits. Biochemical and Biophysical Research Communications 2014, 450: 353–359

9. Ke Shen, Li Ma, Yi Li, Yanyan Qiu, Daling Cui, Yanhua Lu, Peihao Yin, Jianwen Liu*: A Post-Transcriptional Regulation of Tumor Suppressor MiR-139-5p and A Network of MiR-139-5p Mediated mRNAs Interactions in Colorectal Cancer. FEBS Journal 281 (2014) 3609–3624

10. Zujun Que, Fangyuan Zou, Anle Zhang, Yuanhong Zheng, Ling Bi, Jian-Jiang Zhong, Jianhui Tian, Jianwen Liu,* Ganoderic acid Me induces the apoptosis of competent T cells and increases the proportion of Treg cells through enhancing the expression and activation of Indoleamine 2,3-Dioxygenase in Mouse Lewis Lung Cancer Cells. International Immunopharmacology 2014,23: 192–204

11. Anle Zhang, Yuanhong Zheng, Zujun Que, Lingling Zhang, Shengchao Lin, Vanminh Le, Jianwen Liu*, Jianhui Tian: Astragaloside IV inhibits progression of lung cancer via mediate immune function of Tregs and CTLs by interfere with IDO. J Cancer Res Clin Oncol 2014, 140:1883-1890

12. Shengchao Lin, Kecheng Lei, Lingling Zhang, Yanhua Lu, Ping Liu, Jianwen Liu*: Development of a multifunctional luciferase reporters system for assessing Endoplasmic Reticulum-locating anti-tumor photosensitive compounds. Cell Stress & Chaperones 2014, 19:927–937

13. Lei Liang, Sheng Xie, Lin Jiang, Hui Jin, Songgang Li, Jianwen Liu*: The Combined Effects of Hematoporphyrin monomethyl ether-SDT and Doxorubicin on the proliferation of QBC cell lines. Ultrasound in Med. & Biol., 2013; (39) 1:146–160

14. Ke Xu, Xin Liang, Daling Cui, Yixin Wu, Weibin Shi and Jianwen Liu*: miR-1915 Inhibits Bcl-2 to Modulate Multidrug Resistance by Increasing Drug-Sensitivity in Human Colorectal Carcinoma Cells. Mol Carcinogen 52:70–78 (2013)

15. Ke Shen, Liyun Sun, Huanying Zhang, Yufang Xu, Xuhong Qian, Yanhua Lu, Qi Li, Lei Ni, Jianwen Liu*: A ROS-mediated lysosomal–mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells. Cancer Letters 2013,333: 229–238

16. Yuanhong Zheng & Vanminh Le & Zhuoan Cheng & Sheng Xie & Hegeng Li & Jianhui Tian and Jianwen Liu*: Development of rapid and highly sensitive HSPA1A promoter-driven luciferase reporter system for assessing oxidative stress associated with low-dose photodynamic therapy Cell Stress and Chaperones 2013,18:203–213

17. Hui Jin, Lei Liang, Li-Feng Liu, Wei-Ping Deng, and Jianwen Liu*: HDAC Inhibitor DWP0016 Activates p53 Transcription and Acetylation to Inhibit Cell Growth in U251 Glioblastoma Cells. J Cell Biochem 2013,114:1498–1509

18. Zhuoan Cheng & Shaobo Qiu & Lin Jiang & Anle Zhang & Wenjing Bao & Ping Liu & Jianwen Liu*: MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1 J Clin Immunol 2013, 33:567–576

19. Yichun Xu, Zijing Jiang, Peihao Yin, Qi Li, Jianwen Liu,*: Role for Class I histone deacetylases in multidrug resistance Exp Cell Res 318 (2012) 117-186

20. Ke Shen,1 Daling Cui, Liyun Sun, Yanhua Lu, Mingquan Han, and Jianwen Liu* Inhibition of IGF-IR Increases Chemosensitivity in Human Colorectal Cancer Cells Through MRP-2 Promoter Suppression J Cell Biochem 113:2086–2097 (2012)