2015.01--今，华东理工大学，生物工程学院，教授

2014.11-2014.12，比利时根特（Ghent）大学，理学院生物医学分子生物学系，高级访问教授

2010/09-2014.10，华东理工大学，生物工程学院，教授

2005/12-2010/08，华东理工大学，生物工程学院，副教授

2004/10-2005/10，英国Strathclyde大学，理学院，访问学者

1992/08-2004/08，江西农业大学，生物技术研发中心，见实研究员、讲师

1、工业微生物发酵生理与分子调控：主要对工业微生物在发酵过程中与培养环境之间的相互作用关系，包括环境条件对微生物细胞在发酵过程的生理变化影响机制，如碳中心代谢途径的改变引起代谢产物的合成效率；同时，研究细胞发酵生理对培养环境的影响，为建立工业化发酵过程控制提供理论基础。

2、动物细胞大规模培养工程：主要对CHO细胞、BHK21、HEK293、Vero细胞、干细胞（如骨髓间充质干细胞、小鼠胚胎干细胞、神经干细胞等）、原代组织细胞（如睾丸支持细胞等）等生物反应器大规模培养与抗体（疫苗）工程化技术研究，建立高密度的生物反应器培养技术和在线检测技术，以及大规模生物反应器设计技术研究

Hong-Tu Zhao, Kun-Yun Pang, Wei-Lu Lin, Ze-Jian Wang, Da-Qi Gao, Mei-Jin Guo*,Ying-Ping Zhuang. Optimization of the n-propanol concentration and feedback controlstrategy with electronic nose in erythromycin fermentation processes. Process Biochemistry,2015, dx.doi.org/10.1016/j.procbio.2015.12.001

Zhi-Qiang Xiong, Mei-Jin Guo*, Ju Chu, Ying-Ping Zhuang, Si-liang Zhang, On-line specific growth rate control for improving reduced glutathione production in Saccharomyces cerevisiae. Biotechnology & Bioprocess Engineering. 2015,20(5):887-893

Taicheng Zhu, Haifeng Hang, Ju Chu, Yingping Zhuang, Siliang Zhang and Meijin Guo*. Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichia pastoris. Journal of Industrial Microbiology & Biotechnology. 2013: 40:183-189

Lan Yu, Xiangyun Yan, Long Wang, Ju Chu, Yingping Zhuang, Siliang Zhang and Meijin Guo*. Molecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus. BMC Biotechnology 2012, 12:52

Xiaohe Chu, Zijing Zhen, Zhenyu Tang, Yingping Zhuang, Ju Chu, Siliang Zhang1 and Meijin Guo*. Introduction of extra copy of oxytetracycline resistance gene otrB enhances the biosynthesis of oxytetracycline in Streptomyces rimosus. J Bioprocess Biotechniq 2012, 2:117

Lan Yu, Nan Cao, Long Wang, Ciying Xiao, Meijin Guo*, Ju Chu, Yingping Zhuang, Siliang Zhang. Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes, Enzyme and Microbial Technology, 2012,50(6):318–324

Zhenyu Tang, Paul R. Herron, Iain S. Hunter, Siliang Zhang and Meijin Guo*. Insight into microevolution of Streptomyces rimosus based on analysis of zwf and rex genes. African Journal of Microbiology Research ,2012,6(24):5229-5236

Zhenyu Tang, Ciying Xiao, Yingping Zhuang, Ju Chu, Siliang Zhang, Paul R. Herron, Iain S. Hunter, Meijin Guo*.Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway. Enzyme and Microbial Technology, 2011,49( 1): 17–24

Zhenyu Tang, Yingping Zhuang, Ju Chu, Siliang Zhang, Paul Herron, Iain S. Hunter and Meijin Guo*. A molecular Redox Sensor from Streptomyces rimosus M4018 for Escherichia coli . African Journal of Microbiology Research, 2011, 5(31): 5682-5688

Florence E. Pethick, Alison C. MacFadyen, Zhenyu Tang, Vartul Sangal, Tze-Tze Liu, Ju Chu, Gregor Kosec, Hrvoje Petkovic, Meijin Guo, Ralph Kirby, Paul A. Hoskisson, Paul R. Herron, Iain S. Hunter. Draft genome sequence of the oxytetracycline-producing bacterium Streptomyces rimosus ATCC 10970. Genome Announc. 2013,1(2): e00063-13. doi: 10.1128/genomeA.00063-13. PMCID: PMC3593331

Taicheng Zhu , Meijin Guo* , Yingping Zhuang ,Ju Chu and Siliang Zhang. Understanding the effect of foreign gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes. Appl Microbiol Biotechnol. 2011, 89:1127–1135

Zhi-Qiang Xiong, Mei-Jin Guo*, Yuan-Xin Guo, Ju Chu, Ying-Ping Zhuang, Nam Sun Wang and Si-Liang Zhang. RQ feedback control for simultaneous improvement of GSH yield and GSH content in Saccharomyces cerevisiae T65. Enzyme and Microbial Technology. 2010, 46 (7): 598-602

Taicheng Zhu, Meijin Guo*, Ming Zhang, Zhenyu Tang, Yingping Zhuang, Ju Chu, Siliang Zhang. Efficient generation of multi-copy strains for optimizing secretory expression of porcine insulin precursor in yeast Pichia pastoris, Journal of Applied Microbiology . 2009,107: 954–963

Taicheng Zhu, Meijin Guo*, Chen Sun, JuChu, Yingping Zhuang, SiliangZhang.A systematical investigation on the genetic stability of multi-copy Pichia pastoris strains.Biotechnol Lett. 2009. 31:679-684

Haifeng Hang, Xinhao Ye, Meijin Guo*, Ju Chu, Yingping Zhuang, Ming Zhang, Siliang Zhang. A simple fermentation strategy for high-level production of recombinant phytase by Pichia pastoris using glucose as the growth substrate. Enzyme and Microbial Technology 2009,44:185–188

Zhiqiang Xiong, Meijin Guo*, Yuanxin Guo, Ju Chu, Yingping Zhuang, Siliang Zhang, Efficient extraction of intracellular reduced glutathione from fermentation broth of Saccharomyces cerevisiae by ethanol, Bioresource Technology, 2009, 100 :1011–1014

Zhiqiang Xiong, Meijin Guo*, Yuanxin Guo, Ju Chu,Yingping Zhuang and Siliang Zhang. Real time viable cell mass monitoring in high-cell-density fed-batch glutathione fermentation with industrial complex medium by Saccharomyces cerevisiae T65. Journal of Bioscience and Bioengineering, 2008, 105:409-413

Xiao-Qing Hu, Ju Chu, Zhuo Zhang, Si-Liang Zhang, Ying-Ping Zhuang, Yong-Hong Wang, Meijin Guo*, Hua-Xin Chen, Zhong-Yi Yuan. Effects of different glycerol feeding strategies on S-adenosyl-L-methionine biosynthesis by PGAP-driven Pichia pastoris overexpressing methionine adenosyltransferase. Journal of Biotechnology ,2008, 137(1-4):44-49

Haifeng Hang, Wen Chen, Meijin Guo*, Ju Chu, Yingping Zhuang, Siliang Zhang, A simple unstructured model-based control for efficient expression oe recombination porcine insulin precursor by Pichia pastoris, Korean Journal of Chemical Engineering. 2008, 25(5):1065-1069

Meijin Guo, Haifeng Hang, Taicheng Zhu, Yingping Zhuang*, Ju Chu, Siliang Zhang. Effect of glycosylation on biochemical characterization of recombinant phytase expressed in Pichia pastoris. Enzyme and Microbial Technology, 2008,43:334-338