招生专业 院系名称 专业大类 一级学科 专业代码/专业 名称 学位类型 招生类型 交叉科学研究院 医学 中药学 100800/中药学 学术学位 硕士 交叉科学研究院 医学 中药学 105600/中药学 专业学位 硕士

教育及任职经历 1994.9-1998.7 中国海洋大学 学士 1998.9-2001.7 中国海洋大学 硕士 2003.9-2006.7 中国科学院上海药物研究所 博士 2001.7-2009.8 中国科学院上海药物研究所 研究实习员、助理研究员、高级工程师 2009.9-2014.1 中国科学院上海药物研究所 副研究员 2014.1-2015.1 Emory University 访问学者 2015.1-2018.12 中国科学院上海药物研究所 副研究员 2019.1-至今 上海中医药大学交叉科学研究院 研究员

近五年以第一负责人承担的科研课题与经费 序号课题类型项目时间项目经费（万元）备注 1上海市科委自然科学基金面上项目2020.07-2023.0620主持 2上海卫健委中医药防治新冠肺炎科研项目2020.02-2020.06 10主持 3上海中医药大学应急科研攻关项目 2020.02-2020.06 20主持 4上海中医药大学人才引进 2019.01-2022.01 80 主持

1、天然产物抗感染、抗肿瘤分子机制、信号通路以及化学生物学研究

2、创新药物研究

1. Liqiang Ni#, Lili Chen#, Xia Huang#, Chouping Han, Hong Zhang, Xin Luan, Yongfang Zhao, Jianguang Xu, Weian Yuan*, Hongzhuan Chen*. Combating COVID-19 with integrated traditional Chinese and Western medicine in China. Acta Pharm Sin B. 2020,10(7):1149-1162. (IF=14.903)

2. Shaopeng Yu#, Yuying Zhu#, Jiaruo Xu, Guangtao Yao, Pei Zhang, Mengge Wang, Yongfang Zhao, Guoqiang Lin, Hongzhuan Chen*, Lili Chen*, Jiange Zhang*. Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2. Phytomedicine. 2021, 85:153364. (IF=6.656)

3. Yiming Yin, Mengge Wang, Wenjie Gu, Lili Chen*. Intestine-Specific FXR agonists as potential therapeutic agents for Colorectal Cancer. Biochem Pharmacol. 2021, 186:114430. (IF=6.100)

4. Ruyu Wang#, Qing Hu#, Haonan Wang, Guanghao Zhu, Mengge Wang, Qian Zhang, Yishu Zhao, Chunyu Li, Yani Zhang, Guangbo Ge*,Hongzhuan Chen*, Lili Chen*, Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CL. Int J Biol Macromol, 2021, 183:182-192. (IF=8.025)

5. Yusen Xiang, Mengge Wang, Hongzhuan Chen*, Lili Chen*, Potential therapeutic approaches for the early entry of SARS-CoV-2 by interrupting the interaction between the spike protein on SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2). Biochem Pharmacol. 2021, 192:114724. (IF=6.100)

6. Shaopeng Yu#, Yao Chen#, Yusen Xiang#, He Lin, Mengge Wang, Wenbo Ye, Pei Zhang, Hongzhuan Chen, Guoqiang Lin, Yuying Zhu, Lili Chen*, Jiange Zhang*, Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect. Phytother Res. 2021, 35(10):5847-5860. (IF=6.388)

7. Jiacheng Xiong#, Yusen Xiang#, Ziming Huang, Xiaohong Liu, Mengge Wang, Guangbo Ge, Hongzhuan Chen, Jianrong Xu*, Mingyue Zheng*, Lili Chen*. Structure-based virtual screening and identification of potential inhibitors of SARS-CoV-2 S-RBD and ACE2 interaction, Front Chem. 2021, 9:740702. (IF= 5.545)

8. Ye Wu, Rui Huang, Jin-Mei Jin, Li-Jun Zhang, Hong Zhang, Hong-Zhuan Chen, Li-Li Chen*, Xin Luan*. Advances in the Study of Structural Modification and Biological Activities of Anoplin. Front Chem. 2020, 8:519. (IF= 5.545)

9. Guang-Hui Ma#, Yan Ye#, Dan Zhang#, Xin Xu, Pei Si, Jian-Long Peng, Yong-Long Xiao, Rui-Yuan Cao, Yu-Ling Yin, Jing Chen, Lin-Xiang Zhao, Yu Zhou*, Wu Zhong, Hong Liu, Xiao-Min Luo*, Li-Li Chen*, Xu Shen. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016, 124:981-991. (IF= 7.088)

10. Xing Xu, Xin Xu, Peng Liu, Zhi-yuan Zhu, Jing Chen, Hai-an Fu, Li-li Chen*, Li-hong Hu*, Xu Shen*. Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor. J Biol Chem. 2015, 290(32):19888-99. (IF= 5.486)