李根喜，男，1965年 2月生，山东省嘉祥县人，国家杰出青年基金获得者。 1984～1994年，在南京大学化学系高分子化学、分析化学专业学习，分别获学士、硕士和博士学位，1994年6月在该校生化系做博士后，1996年5月出站并留生化系任教，1996～2000年为副教授，2001年为教授、博导，其中，1998～2000年分别在德国慕尼黑大学生物系、日本东北大学药学部、美国哈佛大学医学院生化与分子药学系作访问学者。1999.1～2010.5任南京大学生化系系主任，2006年任上海大学兼职教授，2008.11～2011.10任上海大学生命科学学院院长。主要从事生物分子识别与传感及定量分析方法的研究。已发表SCI论文230余篇，他引6500余次，参编《Encyclopedia of Sensors》”等丛书,并编写了《Electrochemical Analysis of Proteins and Cells》等专著，“基于蛋白质电化学发展新型生物传感器的研究”及“蛋白质定量及活性表征的电化学研究”分别于2010、2014年获教育部自然科学二等奖，“生物分子界面作用过程的机制、调控及生物分析应用研究”获2016年国家自然科学二等奖。 先后担任中国生物化学与分子生物学会理事会理事、蛋白质专业委员会副秘书长、副主任兼秘书长、中国生物物理学会理事会理事、中国仪器仪表学会化学传感器专业委员会委员。

1. 蛋白质的电子传递、电化学及界面行为。 2. 蛋白质功能与结构的电化学研究。 3. 纳米生物学。 4. 分子识别、组装及相互作用。 5. 新型第三代生物传感器的研制。 6. 生物信号分子研究及相关信号传导机制探索。

近期论文 1. Lei Wang, Yanhong Pan, Yunfei Liu, Zhaowei Sun, Yue Huang, Jinlong Li, Jie Yang, Yang Xiang, Genxi Li*, Fabrication of an aptamer-coated liposome complex for the detection and profiling of exosomes based on terminal deoxynucleotidyl transferase-mediated signal amplification, ACS Appl. Mater. Interfaces, 2020, 12: 322-329 2. Zhaowei Sun, Lei Wang, Shuai Wu, Yanhong Pan, Yu Dong, Sha Zhu, Jie Yang, Yongmei Yin*, Genxi Li*, An electrochemical biosensor designed by using Zr-based metal-organic frameworks for the detection of glioblastoma-derived exosomes with practical application, Anal. Chem., 2020, 92: 3819-3826 3. Menglu Li, Tian Tian, Yujing Zeng, Sha Zhu, Jianyang Lu, Jie Yang, Chao Li*, Yongmei Yin*, Genxi Li*, Individual cloud-based fingerprint operation platform for latent fingerprint identification using perovskite nanocrystals as eikonogen, ACS Appl. Mater. Interfaces, 2020, 12: 13494-13502 4. Ji Zheng, Hai Shi, Mengjiao Wang, Chengjie Duan, Yue Huang, Chao Li, Yang Xiang*, Genxi Li*, Homogenous electrochemical method for ultrasensitive detection of tumor cells designed by introduction of poly(A) tails onto cell membranes, Anal. Chem., 2020, 92: 2194-2200 5. Lan Xue, Yi Yang, Shuai Wu, Yue Huang, Jinlong Li, Yang Xiang*, Genxi Li*, In situ reduction of porous copper metal-organic frameworks for three-dimensional catalytic click immunoassay, Anal. Chem., 2020, 92: 2972-2978 6. Jin Jiao, Chao Li, Limin Ning, Liu Shi, Lin Wang, Yang Xiang*, Genxi Li*, Electrochemical detection of circRNAs based on the combination of backsplice junction and duplex-specific nuclease, Sensors and Actuators B, 2020, 302: 127166 7. Ying Peng, Shuai Wu, Zhaowei Sun, Sha Zhu, Yongmei Yin*, Genxi Li*, Multiple signal amplification via coupling DNAzyme with strand displacement reaction for sensitive colorimetric analysis of MUC1, Sensors and Actuators B, 2020, 313: 128046 8. Hai Shi, Ji Zheng, Yanxia Wang, Sha Zhu, Yang Xiang, Xiaoli Zhu*, Genxi Li*, Point-of-care testing of protein biomarkers by integrating a personal glucose meter with a concatenated DNA amplifier, Sensors and Actuators B, 2020, 322: 128659 9. Yue Huang, Lei Wang, Lingjun Sha, Yaosong Wang, Xuguo Duan, Genxi Li*, Highly sensitive detection of lipopolysaccharide based on collaborative amplification of dual enzymes, Anal. Chim. Acta, 2020, 1126: 31-37 10. Yi Yang, Chao Li, Hai Shi, Tianshu Chen, Zhaoxia Wang*, Genxi Li*, A pH-responsive bioassay for paper-based diagnosis of exosomes via mussel inspired surface chemistry, Talanta, 2019, 192: 325-330 11. Liu Shi, Chaoli Mu, Tao Gao, Wenxin Chai, Anzhi Sheng, Tianshu Chen, Jie Yang, Xiaoli Zhu*, Genxi Li*, Rhodopsin-like ionic gate fabricated with graphene oxide and isomeric DNA switch for efficient photocontrol of ion transport, J. Am. Chem. Soc., 2019, 141: 8239-8243 12. Zhaowei Sun, Shuai Wu, Jiehua Ma, Hai Shi, Lin Wang, Anzhi Sheng, Tingting Yin, Lizhou Sun*, Genxi Li*, Colorimetric sensor array for human semen identification designed by coupling zirconium metal-organic frameworks with DNA modified gold nanoparticles, ACS Appl. Mater. Interfaces 2019, 11: 36316-36323 13. Tao Gao, Wenxin Chai, Liu Shi, Hai Shi, Anzhi Sheng, Jie Yang*, Genxi Li *, A new colorimetric assay method for the detection of anti-hepatitis C virus antibody with high sensitivity, Analyst, 2019, 144: 6365-6370 14. Ji Zheng, Tao Gao, Hai Shi, Yue Huang, Yang Xiang*, Genxi Li*, Electrochemical analysis of 8-hydroxy-2’-deoxyguanosine with enhanced sensitivity based on exonuclease-mediated functional nucleic acid, Talanta, 2019, 199: 324-328 15. Lei Wang, Yucai Yang, Yunfei Liu, Limin Ning, Yang Xiang, Genxi Li*, Bridging exosome and liposome through zirconium-phosphate coordination chemistry: A new method for exosome detection, Chem. Commun., 2019, 55: 2708-2711 16. Jiehua Ma, Lan Xue, Meiling Zhang, Chao Li, Yang Xiang, Ping Liu*, Genxi Li*, An electrochemical sensor for Oct4 detection in human tissue based on target-induced steric hindrance effect on a tetrahedral DNA nanostructure, Biosensors and Bioelectronics, 2019, 127: 194-199 17. Shuai Wu, Yiwei Han, Lin Wang, Jinlong Li, Zhaowei Sun, Meiling Zhang, Ping Liu*, Genxi Li*, Sensor array fabricated with nanoscale metal-organic frameworks for the histopathological examination of colon cancer, Anal. Chem., 2019, 91: 10772-10778 18. Yi Yang, Lan Xue, Ji Zheng, Chao Li, Yue Huang, Yang Xiang, Zhaoxia Wang*, Genxi Li*, Erythrocyte membrane-biointerfaced spherical nucleic acids: Robust performance for microRNA quantification, Anal. Chim. Acta, 2019, 1080: 189-195 19. Hai Shi, Yanxia Wang, Ji Zheng, Limin Ning, Yue Huang, Anzhi Sheng, Tianshu Chen, Yang Xiang, Xiaoli Zhu*, Genxi Li*, Dual-responsive DNA nanodevice for the available imaging of an apoptotic signaling pathway in Situ, ACS Nano 2019, 13: 12840-12850 20. Jiehua Ma, Wenxin Chai, Jianyang Lu, Tian Tian, Shuai Wu, Yucai Yang, Jie Yang, Chao Li*, Genxi Li*, Coating a DNA self-assembled monolayer with a metal organic framework-based exoskeleton for improved sensing performance, Analyst, 2019, 144, 3539-3545 21. Juan Zhang, Hong Chen, Ya Cao, Chang Feng, Xiaoli Zhu*, Genxi Li*, Design nanoprobe based on its binding with amino acid residues on cell surface and its application to electrochemical analysis of cells, Anal. Chem., 2019, 91: 1005-1010 22. Lingling Li, Hai Shi, Anzhi Sheng, Yi Yang, Liu Shi, Chao Li*, Genxi Li*, A novel method to engineer proteases for selective enzyme inhibition, Chem. Commun., 2019, 55: 14039-14042 23. Jingjing Xu, Lingling Li, Hai Shi, Chang Feng, Anzhi Sheng, Chao Li*, Genxi Li*, Fabrication of gold nanoparticle@protease for cancer therapy and disinfection, Inorg. Chem. Commun., 2019, 107: 107456 24. Yue Huang, Ji Zheng, Lei Wang, Xuguo Duan, Yaosong Wang, Yang Xiang, Genxi Li*, Sensitive detection of chloramphenicol based on Ag-DNAzyme-mediated signal amplification modulated by DNA/metal ion interaction, Biosensors and Bioelectronics, 2019, 127: 45-49 25. Tao Gao, Tianshu Chen, Chang Feng, Xiang He, Chaoli Mu, Jun-ichi Anzai, Genxi Li*, Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells, Nat. Commun., 2019, 10: 2946 26. Tao Gao, Lingling Li, Tianshu Chen, Liu Shi, Yang Yang, Genxi Li*, DNA-oriented shaping of cell features for the detection of rare disseminated tumor cells, Anal. Chem., 2019, 91: 1126-1132 27. Chang Feng, Zihan Wang, Tianshu Chen, Xiaoxia Chen, Dongsheng Mao, Jing Zhao*, Genxi Li*, A dual-enzyme-assisted three-dimensional DNA walking machine using T4 polynucleotide kinase as activators and application in polynucleotide kinase assays, Anal. Chem. 2018, 90, 2810-2815 28. Hai Shi, Tao Gao, Liu Shi, Tianshu Chen, Yang Xiang, Yuanyang Li*, Genxi Li*, Molecular imaging of telomerase and the enzyme activity triggered drug release by using a conformation-switchable nanoprobe in cancerous cells, Sci. Rep., 2018, 8: 16341 29. Jin Jiao, Tao Gao, Hai Shi, Anzhi Sheng, Yang Xiang*, Yongqian Shu*, Genxi Li*, A method to directly assay circRNA in real samples, Chem. Commun., 2018, 54: 13451-13454 30. Chao Li, Jianyang Lu, Xiaolu Hu, Chang Feng, Yang Xiang, Yannis Karamanos, Genxi Li*, Assembly of nanoconjugates as new kind inhibitor of the aggregation of amyloid peptides associated with Alzheimer’s disease, Part. Part. Syst. Charact., 2018, 35: 1700384 31. Jinlong Li, Guangwu He, Bei Wang, Liu Shi, Tao Gao, Genxi Li*, Fabrication of reusable electrochemical biosensor and its application for the assay of α-glucosidase activity, Anal. Chim. Acta, 2018, 1026: 140-146 32. Chao Li, Jiehua Ma, Hai Shi, Xiaolu Hu, Yang Xiang, Yuanyang Li*, Genxi Li*, Design of a stretchable DNAzyme for sensitive and multiplexed detection of antibodies, Anal. Chim. Acta, 2018, 1041: 102-107 33. Xiaoxia Chen, Jing Zhao, Tianshu Chen, Tao Gao, Xiaoli Zhu*, Genxi Li*, Nondestructive analysis of tumor-associated membrane protein integrating imaging and amplified detection in situ based on dual-labeled DNAzyme, Theranostics, 2018, 8: 1075-1083 34. Juan Zhang, Defeng Li, Xiquan Yue, Meiling Zhang, Ping Liu*, Genxi Li*, Colorimetric in situ assay of membrane-bound enzyme based on lipid bilayer inhibition of ion transport, Theranostics, 2018, 8: 3275-3283 35. Xiaoxia Mao, Guifang Chen, Zihan Wang, Yuanguang Zhang, Xiaoli Zhu*, Genxi Li*, Surface-immobilized and self-shaped DNA hydrogels and their application in Biosensing, Chem. Sci., 2018, 9: 811-818 36. Genxi Li, “Nano-inspired biosensors for protein assay with clinical applications”, Elsevier, Cambridge, United States, 2018 37. Liu Shi, Chaoli Mu, Tao Gao, Tianshu Chen, Shuang Hei, Jie Yang*, Genxi Li*, DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection, Chem. Commun., 2018, 54: 11391-11394