教育背景 博士 2002.09-2007.07 山东大学 微生物学 学士 1998.09-2002.07 东北师范大学 生物科学 工作经历 2019.9-今 山东大学微生物技术国家重点实验室教授、博导/硕导 2019.9-2020.11济南市历城区人民政府党组成员、副区长（挂职） 2014.4-2016.7 山东省德州乐陵市人民政府副市长（挂职） 2012.9-2019.8山东大学微生物技术国家重点实验室副教授 2010.9-2012.8 美国麻省理工学院（MIT）生物系博士后 2007.7-2010.8 山东大学生命科学学院师资博士后，讲师

1. 工业真菌蛋白表达和分泌机制研究，包括蛋白质折叠、内质网响应以及运输分泌的机制，特别是对异源蛋白表达调控的机制。2. 新型纤维素酶或组合酶系的研究，包括不同生境纤维素酶系的开发、酶系组合的设计以及纤维素降解酶的工程改造等。3. 食品微生物工程改良，包括黑曲霉低聚果糖合成菌工程改造与工艺优化、营养缺陷型遗传体系构建等。

1.Zhang Jiaxin, Li Kehang, Sun Yu, Yao Cheng, Liu Weifeng, Liu Hong*,Zhong Yaohua*. An efficient CRISPR/Cas9 genome editing system based on a multiple sgRNA processing platform inTrichoderma reeseifor strain improvement and enzyme production.Biotechnology for Biofuels and Bioproducts. 2024, 17(1): 22. (*通讯作者) 2.Zhang Jiaxin, Hong Yu, Li Kehang, Sun Yu, Yao Cheng, Ling Jianya*,Zhong Yaohua*. Enhancing the production of a heterologous Trametes laccase (LacA) by replacement of the major cellulase CBH1 inTrichoderma reesei.Journal of Industrial Microbiology & Biotechnology. 2023, 50(1): kuad002. (*通讯作者) 3.Cheng Yao, Ningning Sun, Weihao Gao, Yu Sun, Jiaxin Zhang, Hong Liu andYaohua Zhong*. Overexpression of a novel vacuolar serine protease-encoding gene (spt1) to enhance cellulase production inTrichoderma reesei.Fermentation, 2023, 9 (2), 191. (*通讯作者) 4.Wang Lu, Xie Yijia, Chang Jingjing, Wang Juan, Liu Hong, Shi Mei*,Zhong Yaohua*. A novel sucrose-inducible expression system and its application for production of biomass-degrading enzymes inAspergillus niger.Biotechnology for Biofuels and Bioproducts. 2023, 16(1): 23. (*通讯作者) 5.Yao Cheng, Yan Mengjie, Li Kehang, Gao Weihao, Li Xihai, Zhang Jiaxin, Liu Hong*,ZhongYaohua*. The ERAD pathway participates in fungal growth and cellulase secretion in Trichoderma reesei.Journal of Fungi, 2023, 9 (1), 74. (*通讯作者) 6.Wang Yubo, Ren Meibin, Wang Yifan, Wang Lu, Liu Hong, Shi Mei*,ZhongYaohua*. Constitutive overexpression of cellobiohydrolase 2 inTrichoderma reeseireveals its ability to initiate cellulose degradation,Engineering Microbiology, 2023, 3 (1), 100059. (*通讯作者) 7.Shen Linjing, Yan Aiqin, Wang Yifan, Wang Yubo, Liu Hong,Zhong Yaohua*. Tailoring the expression of Xyr1 leads to efficient production of lignocellulolytic enzymes in Trichoderma reesei for improved saccharification of corncob residues.Biotechnology for Biofuels and Bioproducts, 2022, 15(1):142. (*通讯作者) 8.Sun Yu, Qian Yuanchao, Zhang Jiaxin, Yao Cheng, Wang Yifan, Liu Hong*,Zhong Yaohua*. Development of a novel expression platform for heterologous protein production via deleting the p53-like regulator Vib1 inTrichoderma reesei.Enzyme and Microbial Technology, 2022, 155: 109993. (*通讯作者) 9.Yifan Wang, Ruiyan Liu, Hong Liu, Xihai Li, Linjing Shen, Weican Zhang, Xin Song, Weifeng Liu, Xiangmei Liu*,Yaohua Zhong*. Development of a powerful synthetic hybrid promoter to improve the cellulase system ofTrichoderma reeseifor efficient saccharification of corncob residues.Microbial Cell Factories, 2022, 21(1): 5. (*通讯作者) 10.Shen Linjing, Gao Jia, Wang Yifan, Li Xihai, Liu Hong*,Zhong Yaohua. Engineering the endoplasmic reticulum secretory pathway in Trichoderma reesei for improved cellulase production.Enzyme and Microbial Technology. 2022, 152: 109923. (*通讯作者) 11.Wang Juan, Zhang Jing, Wang Lu, Liu Hong, Li Ning, Zhou Huanxia, Ning Zhanguo, Zhang Weican, Wang Lushan, Huang Feng*,Zhong Yaohua*. Continuous production of fructooligosaccharides by recycling of the thermal-stableβ-fructofuranosidase produced byAspergillus niger.Biotechnology Letters. 2021, 43 (6): 1175-1182. (*通讯作者) 12.Sun Y, Qian Y, Zhang J, Wang Y, Li X, Zhang W, Wang L, Liu H*,Zhong Y*. Extracellular protease production regulated by nitrogen and carbon sources inTrichoderma reesei.Journal of Basic Microbiology, 2021 61(2): 122-132. (*通讯作者） 13.Ren M, Wang Y, Liu G, Zuo B, Zhang Y, Wang Y, Liu W, Liu X*,Zhong Y*. The effects of deletion of cellobiohydrolase genes on carbon source-dependent growth and enzymatic lignocellulose hydrolysis inTrichoderma reesei.Journal of Microbiology, 2020, 58(8):687-695. (*通讯作者） 14.Qian Y, Zhong L, Sun Y, Sun N, Zhang L, Liu W, Qu Y,Zhong Y*. Enhancement of cellulase production inTrichoderma reeseivia disruption of multiple protease genes identified by comparative secretomics.Frontiers in Microbiology, 2019, 10: 2784. (*通讯作者) 15.Qian Y, Sun Y, Zhong L, Sun N, Sheng Y, Qu Y,Zhong Y*. The GATA-type transcriptional factor Are1 modulates the expression of extracellular proteases and cellulases inTrichoderma reesei.International Journal of Molecular Sciences, 2019, 20, 4100. (*通讯作者) 16.Zhang J, Wang L, Luan C, Liu G, Liu J,Zhong Y*. Establishment of a rapid and effective plate chromogenic assay for screening ofAspergillusspecies with highβ-fructofuranosidase activity for fructooligosaccharides production.Journal of Microbiological Methods. 2019, 166: 105740. (*通讯作者)