赵忠熙
教授
个人简介
1980-1984:山东大学化学系,获理学学士学位 1984-1987:山东大学化学系,获理学硕士学位 1989-1993:美国杨伯翰大学(Brigham Young University)生化系,获化学博士学位 1993-1995:美国太平洋西北国家实验室(Pacific Northwest National Lab)博士后研究员 1987-1989:山东大学化学系助教 1995-2002:美国默克公司 (Merck & Co.),药物研究开发部研究学者 2002-2009:美国美达贝斯治疗公司 (Metabasis Therapeutics),药物开发部部长、总监 2010至今:山东大学药物制剂与释药系统研究中心,国家特聘教授、中心主任
研究领域
1.新药创制:用于治疗呼吸系统疾病和肿瘤的小分子免疫治疗药物的研发。 2.中药大品种再开发:用于治疗肺结核、肺癌、糖尿病肾病、慢阻肺等中药免疫治疗药物的再开发。 3.药剂学研究:吸入、缓控释、靶向纳米、膜制剂等新型给药系统关键技术和相关产品的研究;高端制剂仿制药一致性评价研究。 4.创新医疗器械:用于呼吸系统疾病防治的呼吸治疗仪及配套产品开发。
近期论文
1. Y. Liu, A. Li, X. Feng, X. Jiang, X. Sun, W. Huang, X. Zhu, Z. Zhao,L-menthol alleviates cigarette smoke extract induced lung injury in rats by inhibiting oxidative stress and inflammation via nuclear factor kappa b, p38 MAPK and Nrf2 signalling pathways, RSC Adv., 2018, 8,9353. 2. X. Jiang, X. Zhu, N. Liu, H. Xu, Z. Zhao, S. Li, S. Li, J. Cai and J. Cao, Diallyltrisulfide inhibits growth of NCI-H460 in vitro and in vivo, and ameliorates cisplatin-induced oxidative injury in the treatment of lung Carcinoma,Int. J. Biol. Sci., 2017, 13, 167-178. 3. X. Jiang, X. Zhu, W. Huang, H. Xu, Z. Zhao, S. Li, S. Li, J. Cai, J. Cao, Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice, Int. Immunopharm., 2017, 48, 135–145. 4. X. Zhu, X. Jiang, A. Li, Z. Zhao and S. Li, S-Allylmercaptocysteine Attenuates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation, Nutrients, 2017, 9, 166. 5. X. Zhu, X. Jiang, C. Duan, A. Li, Y. Sun, Q. Qi, Y. Liu, S. Li and Z. Zhao, S-Allylmercaptocysteine induces G2/M phase arrest and apoptosis via ROS-mediated p38 and JNK signaling pathway in human colon cancer cells in vitro and in vivo, RSC Adv., 2017, 7, 49151. 6. X. Zhu, X. Jiang, A. Li, Y. Sun, Y. Liu, X. Sun, X. Feng, S. Li, and Z. Zhao, S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways,Biochem. Biophys. Res. Commun., 2017, 492, 1-6. 7. M. Yang, Z. Dong, Y. Zhang, F. Zhang, Y. Wang and Z. Zhao, Preparation and evaluation of posaconazole-loaded enteric microparticles in rats, Drug Dev. Ind. Pharm., 2017, 43, 618–627. 8. Y. Wang, W. Huang, J. Zhang, M. Yang, Q. Qi, K. Wang, Z. Zhao,The therapeutic effect of Bletilla striata extracts on LPS-induced acute lung injury by the regulations of inflammation and oxidation, RSC Adv., 2016, 6, 89338. 9. Y. Wang, Q. Qi, A. Li, M. Yang, W. Huang, H. Xu, Z. Zhao, and S. Li, Immuno-enhancement effects of YifeiTongluo Granules on cyclophosphamide-induced immunosuppression in Balbc mice, J. Ethnopharmacol., 2016, 194, 72–82. 10. Y. Wang, X. Liu, G. Liu, H. Guo, C. Li, Y. Zhang, F. Zhang, Z. Zhao, H. Cheng, Novel galactosylated biodegradable nanoparticles for hepatocyte-delivery of oridonin, Int. J. Pharm. 2016, 502, 47–60.