[教育经历] 2003.6山东大学医学院 免疫学博士 1990.7山东医科大学药学院 理学硕士 1987.7 山东医科大学药学院 学士 [工作经历] 2004.09-今山东大学药学院免疫药理与免疫治疗学研究所，教授，博导 2009.05-2009.11美国哈佛大学医学院访问学者 2003.09-2006.06中国科学技术大学生物化学与分子生物学 在职博士后 1999.12-2003.12山东省肿瘤免疫与医学基因工程重点实验室，副研究员 1993.07-1999.12山东省医学科学院基础医学研究所，助理研究员 1990.07-1993.07山东省医学科学院基础医学研究所，实习研究员

免疫药理学与免疫治疗学： 1.以核转录因子为靶点的肿瘤免疫基因治疗及相关机制研究； 2.探讨炎症与肿瘤免疫耐受关系； 3.基因修饰NK细胞系用于过继免疫治疗及NK细胞相关新功能基因的发现。

山东省生物技术协会副理事长 中国抗癌协会肿瘤转移专业委员会委员、肿瘤生物治疗专业委员会委员 《中国免疫学杂志》副主编 中国免疫学会基础免疫分会委员、女科学家工作委员会委员

1. Jiang Y, Han Q, Zhao H,Zhang J*. Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis. J Exp Clin Cancer Res. 2021 Jan 6;40(1):13. 2. Hu R, Han Q,Zhang J*. STAT3: A key signaling molecule for converting cold to hot tumors. Cancer Lett. 2020 Oct 1;489:29-40. 3. Li Y, Han Q, Zhao H, Guo Q,Zhang J*. Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma. Front Pharmacol. 2020 Dec 3;11:597520. 4. 燴hao HJ, Han QJ, Wang G, Lin A, Xu DQ, Wang YQ, Zhao LH, Tian ZG,Zhang J*. Poly I:C-based rHBVvac therapeutic vaccine eliminates HBV via generation of HBV-specific CD8+ effector memory T cells. Gut. 2019 Nov;68(11):2032-2043. 5. Yin C, Han Q, Xu D, Zheng B, Zhao X,Zhang J*. SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC. Oncoimmunology. 2019 Apr 17;8(7):1601479. 6. Wang H, Han Q, Zhao H, Xu D,Zhang J*.Single dose HBsAg CS-γ-PGA nanogels induce potent protective immune responses against HBV infection.Eur J Pharm Biopharm. 2018 Mar;124:82-88. 7. Wang G, Lin A, Han Q, Zhao H, Tian Z,Zhang J*.IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection.Eur J Immunol. 2018 Sep;48(9):1470-1480. 8. Han Q, Wang Y, Pang M,Zhang J*. STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC. J Exp Clin Cancer Res. 2017 Nov 7;36(1):156. 9. Yang Y, Han Q, Hou Z, Zhang C, Tian Z,Zhang J*. Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction.Cell Mol Immunol. 2017 May;14(5):465-475. 10. Xu D, Han Q, Hou Z, Zhang C,Zhang J*.miR-146a negatively regulates NK cell functions via STAT1 signaling.Cell Mol Immunol. 2017 Aug;14(8):712-720. 11. 燣in A, Wang G, Zhao H, Zhang Y, Han Q, Zhang C, Tian Z,Zhang J*. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. Oncoimmunology. 2015 Aug 12;5(2):e1074376. 12. Sui Q,Zhang J*, Sun X, Zhang C, Han Q, Tian Z. NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma. J Immunol. 2014 Aug 15;193(4):2016-23. 13. Zhang Y, Lin A, Sui Q, Zhang C, Tian Z,Zhang J*. Phosphorothioate modification of the TLR9 ligand CpG ODN inhibits poly(I:C)-induced apoptosis of hepatocellular carcinoma by entry blockade. Cancer Lett. 2014 Dec 1;355(1):76-84. 14. Sun X, Sui Q, Zhang C, Tian Z,Zhang J*. Targeting blockage of STAT3 in HCC cells augments NK cell functions via reverse HCC-induced immune suppression. Mol Cancer Ther. 2013 Dec;12(12):2885-96. 15. Jiang W, Zhang C, Tian Z,Zhang J*. hIFN-α gene modification augments human natural killer cell line anti-human hepatocellular carcinoma function. Gene Ther. 2013 Nov;20(11):1062-9.