邢杰
教授
个人简介
2016.7被聘为博士生导师 2014.9被聘为教授 2005.7 ~至今,山东大学药学院任教 2009.4 ~ 2010.4,美国华盛顿大学药学院,访问学者 2002.7 ~ 2005.7,沈阳药科大学药学院获理学博士学位 2000.7 ~ 2002.7 沈阳药科大学药学院攻读硕士并被免试推荐攻读博士 1996.7 ~ 2000.7 沈阳药科大学药学院获理学学士学位
研究领域
代谢酶学:代谢酶表型研究,药物代谢酶的诱导和抑制,药物代谢性相互作用等。 药物代谢新技术:采用高分辨质谱技术结合多种新型数据处理方法快速筛选代谢产物等。 药物代谢机制:反常药动学的代谢机制。 临床前药物代谢动力学性质评价
学术兼职
中国药理学会药物代谢专业委员会委员。
近期论文
1. Xie YW, Zhang YR, Liu HX,Xing J*. Metabolic retroversion of piperaquine (PQ)viahepatic CYP-mediated N-oxidation and reduction: not a potential contributor to the prolonged elimination of PQ.Drug Metab Dispos. 2021; 49(5):379-388. 2. Xie YW, Liu HX, Chen XY,Xing J*. The effect of gastric pH on the pharmacokinetics-pharmacodynamics of naphthoquine in rodents, as well as in human predicted using a PBPK model.Current Drug Metab. 2021; 22, doi: 10.2174/1389200222666210129102411. 3. Wang X, Cai TY, Chen XY, Yang AJ, Xie YW,Xing J*. Rapid profiling of the marker components in Artemisia annua L. and their metabolites in rats using an improved liquid chromatography tandem high-resolution mass spectrometry-based technology.Current Drug Metab. 2021; 22, doi: 10.2174/1389200222666210129160643. 4. Zhang XL, Meng R, Wang HN*,Xing J*. Differential effects of components in Artemisia annua extract on the induction of drug-metabolizing enzyme expression mediated by nuclear receptors.Planta Med. 2020; 86(12):867-875. 5. Xie YW, Liu HX, Sun YH,Xing J*. The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents.Malar J. 2020; 19:71. 6. Wang S, Cai T, Liu H, Yang A,Xing J*. Liquid chromatography-tandem mass spectrometry assay for the simultaneous determination of three major flavonoids and their glucuronidated metabolites in rats after oral administration of Artemisia annua L. extract at a therapeutic ultra-low dose.J Sep Sci. 2019; 42(21):3330-3339. 7. Liu HX, Zhou HC, Cai TY, Yang AJ, Zang MT,Xing J*. The metabolism of piperaquine to its antiplasmodial metabolites and their pharmacokinetic profiles in healthy volunteers.Antimicrob Agents Chemother. 2018; 62(8):e00260-18. 8. Sun YH, Wang SQ, Ji JB, Zhai GX*,Xing J*.Metabolite identification of the antimalarial naphthoquine using liquid chromatography-tandem high-resolution mass spectrometry in combination with multiple data-mining tools.Biomed Chromatogr. 2018; 32(6):e4207 9. Cai TY, Zhang YR, Ji JB,Xing J*. Investigation of the component inArtemisia annuaL. leading to enhanced antiplasmodial potency of artemisinin via regulation of its metabolism.J Ethnopharmacol. 2017; 207:86-91. 10.Xing J*, Zang MT, Liu HX. The application of a novel high-resolution mass spectrometry-based analytical strategy to rapid metabolite profiling of a dual drug combination in humans.Anal Chim Acta. 2017; 993:38-46.